Regulation of Stress Hormone Receptors in the Brain. Our research will provide information on how the brain controls our response to stress and will allow the development of targeted strategies to reduce the possibility during chronic stress of the development of conditions such as anxiety and depression. This will improve mental health outcomes in Australia and add to Australia's economic and social stability.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347607
Funder
Australian Research Council
Funding Amount
$306,000.00
Summary
FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged ex ....FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged expertise as well as priority within their respective institutions. In addition, it will facilitate wide-ranging collaborative arrangements to further develop and exploit this research area.Read moreRead less
Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less
Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce ....Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce knowledge of broad relevance to modern life sciences and its applications in medicine and biotechnology. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
LGBTI experiences of cancer survivorship and care. This project aims to understand the experiences and concerns of cancer survivors and carers within lesbian, gay, bisexual, transgender and intersex communities. This vulnerable population reports higher rates of cancer related distress and dissatisfaction with care than the general population. This project will examine the perspectives of cancer survivors, their carers, and professional stakeholders, to inform targeted patient and carer resource ....LGBTI experiences of cancer survivorship and care. This project aims to understand the experiences and concerns of cancer survivors and carers within lesbian, gay, bisexual, transgender and intersex communities. This vulnerable population reports higher rates of cancer related distress and dissatisfaction with care than the general population. This project will examine the perspectives of cancer survivors, their carers, and professional stakeholders, to inform targeted patient and carer resources, and recommendations for cancer care and policy.Read moreRead less
Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the p ....Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the period, as well as a greater appreciation of the gender-inclusivity of Stoic philosophy. This should provide significant benefits, such as the development of Stoic therapeutic techniques informed by women’s experiences, and the promotion of gender equality through the recognition of women’s intellectual history.Read moreRead less
How ribosomal protein loss affects cell fate. This project aims to challenge the dogma that the ribosome behaves only as a ‘‘house-keeper’’. Ribosomal protein (RP) mutations should, and often do, result in reduced cell growth and stunted animal development. Depletion of RPs in Drosophila blood cells impair stem cells and cause massive tissue overgrowth. This suggests RPs are involved in cell fate determination, which this project will research using genetic models. As ribosomal function is funda ....How ribosomal protein loss affects cell fate. This project aims to challenge the dogma that the ribosome behaves only as a ‘‘house-keeper’’. Ribosomal protein (RP) mutations should, and often do, result in reduced cell growth and stunted animal development. Depletion of RPs in Drosophila blood cells impair stem cells and cause massive tissue overgrowth. This suggests RPs are involved in cell fate determination, which this project will research using genetic models. As ribosomal function is fundamental to the development of all living organisms, this work could have wide implications for understanding all biology – from microbes, insects and plants to humans.Read moreRead less