The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.
Work-related fatal and non-fatal accidents and injuries and exposure to workplace hazards in migrant workers in Australia. Do migrants have worse workplace conditions and more work-related accidents and injuries than Australian-born workers? This project will analyse national deaths and hospital discharge data, and determine best practice methods to include migrant workers in a future cross-sectional study looking at occupational health and safety.
How migration reshapes labour markets: a study of professional service firms. Australia needs skilled migration to maintain its economic growth and replenish its skill base as the population ages. It needs the skills of migrant accountants. This project will identify the barriers migrants face when seeking work in the financial services industry and discover how migration is changing the financial services labour market.
Exposure to workplace hazards among migrant workers in Australia. This project aims to compare the prevalence of exposure to workplace hazards, namely carcinogens and psychosocial risk factors (eg bullying and precarious work), among migrant and Australian-born workers. The international literature suggests that migrant workers are exposed to more workplace hazards than native-born populations, but the evidence base for Australia is patchy despite the fact that Australia has such a large migrant ....Exposure to workplace hazards among migrant workers in Australia. This project aims to compare the prevalence of exposure to workplace hazards, namely carcinogens and psychosocial risk factors (eg bullying and precarious work), among migrant and Australian-born workers. The international literature suggests that migrant workers are exposed to more workplace hazards than native-born populations, but the evidence base for Australia is patchy despite the fact that Australia has such a large migrant population. The anticipated goal of this project is to address this gap in evidence. The intended outcomes are the necessary first step in the process of reducing exposure to harmful substances and behaviours for all workers.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
The Political and Economic Agency of Africans in Australia. This project examines the nature and impact of political and economic agency among African migrants in Australia, using mixed methods (survey, interviews, media and policy analysis). With the right policy settings, African migrants and Australian communities stand to benefit enormously from projected African population growth. However, due to a two decade research focus on African refugees, little is known about the successful navigatio ....The Political and Economic Agency of Africans in Australia. This project examines the nature and impact of political and economic agency among African migrants in Australia, using mixed methods (survey, interviews, media and policy analysis). With the right policy settings, African migrants and Australian communities stand to benefit enormously from projected African population growth. However, due to a two decade research focus on African refugees, little is known about the successful navigation of political and economic life among the wider African diaspora. This project will generate new knowledge offering a blueprint for such policy settings. Outcomes include a monograph, 8 papers, and evidence-based policy advice on enhancing African migrant political and economic engagement in Australia. Read moreRead less
Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first tra ....Re-uniting marsupials and eutherians by embryonic micromanipulation. The unique responsibility for transmitting life from generation to generation normally depends on the gametes. This project will use new reproductive technologies to investigate the properties of the oocyte in reprogramming somatic cell nuclei, and will use the nuclei of both marsupial and eutherian somatic cells to test this. We will also use both marsupial and eutherian genes to insert into the oocyte to create the first transgenic marsupials. We will also investigate the ability of spermatozoa from species of increasing genetic distance to ferttilise marsupial eggs using intracytoplasmic sperm injection (ICSI).Read moreRead less
An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposa ....An X-ray crystallographic investigation into co-receptors on T-lymphocytes. T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposal aims to investigate, using X-ray crystallography as the primary research tool, co- receptors located on T-lymphocytes. This work will gain fundamental insights into co-receptor function.Read moreRead less
A Structural Investigation Into Events Within The Immunological Synapse. The proposed research program, using laboratory-based and synchrotron-based radiation, will provide significant fundamental insight into the processes that control infection. Investigating processes central to immunity is important, as it will further our understanding of these critically-important events. Such knowledge will increase Australia's international research standing, as well as having the potential to generat ....A Structural Investigation Into Events Within The Immunological Synapse. The proposed research program, using laboratory-based and synchrotron-based radiation, will provide significant fundamental insight into the processes that control infection. Investigating processes central to immunity is important, as it will further our understanding of these critically-important events. Such knowledge will increase Australia's international research standing, as well as having the potential to generate novel therapies, such as immunosuppressants.Read moreRead less