We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately exp ....We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately explore the relationship between prothesis wear and PO, or the progression of PO, because of a lack of techniques to image and measure the volume of PO around metal prosthesis components. We have developed a means to accurately and reproducibly measure the volume of bone loss, using CT, and will do so longitudinally in joint replacement patients to obtain the first information about the progression of PO. New computer based methods will be used concurrently to relate prosthesis wear and migration parameters to PO. Patients who come to surgery for replacement of failed prostheses will be investigated further by analysis of the tissues involved in the bone loss around prostheses. Basic science experiments will seek to understand the underlying causes of PO and the findings will be important in interpreting the clinical results. An animal model will be used to seek approaches to inhibiting the pathological response to wear particles. The significance of these studies is that they will lead to improved outcomes for joint replacement patients, increasing the interval to revision surgery, which is both extremely costly and brings an attendant morbidity and mortality.Read moreRead less
A Randomised Controlled Trial Examining Stability Of New Types Of Highly Porous Surfaced Acetabular Components In Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$216,490.00
Summary
Numbers of total hip replacements are steadily increasing. The most common complication of hip replacement is late implant loosening, which can be predicted by early migration. We will examine early migration of a trabecular metal acetabular cup without screws, compared to a titanium fibre metal acetabular cup fixed with screws. Ideally, an acetabular cup would achieve a level of initial stability by press-fit alone without screws, as screws increase the risk of bone loss around the prosthesis.
Population ageing, labour mobility and sustainability of China's economic growth - a dynamic general equilibrium analysis. China is Australia's second largest trading partner. This project will enable Australian policymakers and business partners to gain better understanding of China's macroeconomic performance between 2008 and 2030. Secondly, China is the second largest source of immigrants to Australia. Given that Australia's population is ageing and labour shortages are expected, Australia ma ....Population ageing, labour mobility and sustainability of China's economic growth - a dynamic general equilibrium analysis. China is Australia's second largest trading partner. This project will enable Australian policymakers and business partners to gain better understanding of China's macroeconomic performance between 2008 and 2030. Secondly, China is the second largest source of immigrants to Australia. Given that Australia's population is ageing and labour shortages are expected, Australia may benefit increasingly from the flow of Chinese immigrants. The project will provide Australian policymakers with detailed labour supply forecasts in China disaggregated by age, sex, sector and region that will enable them to develop targeted immigration policies and effectively harness the flow of Chinese emigrants to Australia.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
Transnationalism and diaspora. This study aims to incorporate diaspora, circular migration and transnational linkages into demographic concepts of population and migration. Transnationalism’s replacement of permanent movements as the dominant paradigm in migration studies raises questions for demographic measurement and the study of migration. This project will use traditional demographic data with integrated quantitative and qualitative research to analyse the diaspora–migration–development nex ....Transnationalism and diaspora. This study aims to incorporate diaspora, circular migration and transnational linkages into demographic concepts of population and migration. Transnationalism’s replacement of permanent movements as the dominant paradigm in migration studies raises questions for demographic measurement and the study of migration. This project will use traditional demographic data with integrated quantitative and qualitative research to analyse the diaspora–migration–development nexus. It will study four countries to understand the characteristics of diasporas, their international linkages and their potential for enhancing development in origin countries. This is expected to generate policy advice on how to maximise the economic potential of diaspora.Read moreRead less
The Political and Economic Agency of Africans in Australia. This project examines the nature and impact of political and economic agency among African migrants in Australia, using mixed methods (survey, interviews, media and policy analysis). With the right policy settings, African migrants and Australian communities stand to benefit enormously from projected African population growth. However, due to a two decade research focus on African refugees, little is known about the successful navigatio ....The Political and Economic Agency of Africans in Australia. This project examines the nature and impact of political and economic agency among African migrants in Australia, using mixed methods (survey, interviews, media and policy analysis). With the right policy settings, African migrants and Australian communities stand to benefit enormously from projected African population growth. However, due to a two decade research focus on African refugees, little is known about the successful navigation of political and economic life among the wider African diaspora. This project will generate new knowledge offering a blueprint for such policy settings. Outcomes include a monograph, 8 papers, and evidence-based policy advice on enhancing African migrant political and economic engagement in Australia. Read moreRead less
Settlement outcomes of Syrian-conflict refugee families in Australia. This project aims to focus on the policy responses to, and settlement outcomes for, Syrian-conflict refugee families in Australia with an emphasis on employment and education. The Syrian conflict has generated an unprecedented flow of refugees across Europe and other countries, including Australia. These countries face new challenges in providing successful settlement outcomes for the refugees. Utilising a longitudinal study o ....Settlement outcomes of Syrian-conflict refugee families in Australia. This project aims to focus on the policy responses to, and settlement outcomes for, Syrian-conflict refugee families in Australia with an emphasis on employment and education. The Syrian conflict has generated an unprecedented flow of refugees across Europe and other countries, including Australia. These countries face new challenges in providing successful settlement outcomes for the refugees. Utilising a longitudinal study of 250 refugee families and fieldwork in key areas of high refugee settlement in NSW, Victoria and Queensland, this project will generate comparative insights to identify policy and program responses that lead to the most successful settlement outcomes. Improved employment, education and settlement outcomes for refugees will have economic, social and cultural benefits for Australian society and improve the quality of life of refugees.Read moreRead less
EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level ....Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level of the individual to isolated enteroendocrine cells.Read moreRead less