Characterisation of the oxygen-sensing asparaginyl hydroxylase, FIH-1, and hydroxylase-specific antagonists. This research will provide fundamental information on how cells and whole organisms can sense and respond accordingly to oxygen deficiency. This information is fundamental for our understanding of embryo development and adult life in different environments, and central to the diagnosis and treatment of diseases such as stroke, cardiovascular disease, and cancer. This research will contrib ....Characterisation of the oxygen-sensing asparaginyl hydroxylase, FIH-1, and hydroxylase-specific antagonists. This research will provide fundamental information on how cells and whole organisms can sense and respond accordingly to oxygen deficiency. This information is fundamental for our understanding of embryo development and adult life in different environments, and central to the diagnosis and treatment of diseases such as stroke, cardiovascular disease, and cancer. This research will contribute to our basic knowledge of these processes, provide invaluable information about the specific genes and proteins involved, and provide direct information about the therapeutic potential of specific drugs or inhibitors designed to target this oxygen response in human disease.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100010
Funder
Australian Research Council
Funding Amount
$720,000.00
Summary
A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the ....A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the nation's research priorities. It will enable: fundamental studies of cancer, neural diseases and immune disorders; the development of frontier technologies, such as smart nanomaterials, biosensors and targeted drug delivery; and applied research to help plants and soils adapt to climate variability, and to increase sustainable use of water.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100149
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Spectroscopic imaging for materials, minerals and life sciences. The spectroscopic imaging equipment highlighted in this proposal will produce a number of outcomes of national benefit. First, it will elevate the impact of research in materials, minerals, and life sciences in Australia, all of which are key areas for the national economy and community. Second, the equipment will be integral to the teaching and research nexus and experiential learning facility for a new wave of materials science ....Spectroscopic imaging for materials, minerals and life sciences. The spectroscopic imaging equipment highlighted in this proposal will produce a number of outcomes of national benefit. First, it will elevate the impact of research in materials, minerals, and life sciences in Australia, all of which are key areas for the national economy and community. Second, the equipment will be integral to the teaching and research nexus and experiential learning facility for a new wave of materials science and engineering students to be educated at UniSA in the EIF-funded M2 building at Mawson Lakes. Finally, the anticipated outcomes of the research to be supported are significant and relate clearly to a number of National Research Priorities.Read moreRead less