Using 3D printing to improve access to graphics by vision-impaired people. This project aims to investigate the possible benefits of 3D printing for production of accessible materials for vision-impaired people. Currently tactile graphics are used to provide severely vision-impaired adults and children with access to graphical content used in education and in orientation and mobility training. This project is expected to clarify the kinds of graphics for which 3D prints are better suited than ta ....Using 3D printing to improve access to graphics by vision-impaired people. This project aims to investigate the possible benefits of 3D printing for production of accessible materials for vision-impaired people. Currently tactile graphics are used to provide severely vision-impaired adults and children with access to graphical content used in education and in orientation and mobility training. This project is expected to clarify the kinds of graphics for which 3D prints are better suited than tactile graphics, and to build capacity within the national accessible format provision sector for the production and use of 3D prints. Benefits will include increased educational opportunities and quality of life for Australians with severe vision impairment, through improved access to graphic materials used in education and orientation and mobility training.
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Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
Understanding The Role Of The Atypical Cadherin Fat4 In Lymphatic Vascular Development
Funder
National Health and Medical Research Council
Funding Amount
$1,006,248.00
Summary
This application will define the role of a large cell adhesion molecule, FAT4, in lymphatic vascular development. By understanding how FAT4 functions in lymphatic vessels, we will gain insight to the mechanisms by which mutations in the gene that encodes this protein cause a human lymphoedema syndrome.
Deformable Surfaces Supporting 3D Tactile Human Computer Interactions. This project will support Research Priority 3: Frontier Technologies for Building and Transforming Australian Industries. The results will provide information that will further build our understanding of human computer interactions. Digital Foam supports Smart Information Use by providing a new interaction paradigm for existing and new creative applications for digital technologies. The new form of interaction provides a new ....Deformable Surfaces Supporting 3D Tactile Human Computer Interactions. This project will support Research Priority 3: Frontier Technologies for Building and Transforming Australian Industries. The results will provide information that will further build our understanding of human computer interactions. Digital Foam supports Smart Information Use by providing a new interaction paradigm for existing and new creative applications for digital technologies. The new form of interaction provides a new computer interaction product in itself and the ability to make a more efficient creative environment for designers of 3D content, multi-media and manufacturing design. This technology supports the ability of organisations to operate virtually and collaborate across large distances in Australia and internationally.Read moreRead less
Use of mitochondrial electron transport chain mutants to evaluate how non-phosphorylating respiration influences plant metabolite profiles and stress tolerance. This project uses transgenic plant technology to elucidate how mitochondrial function impacts on the profile of metabolites in plant cell and tissues and whether altering these profiles influences a plant's ability tog row in harsh conditions. It will contribute to our fundamental knowledge of plant metabolism using a metabolomic anaylsi ....Use of mitochondrial electron transport chain mutants to evaluate how non-phosphorylating respiration influences plant metabolite profiles and stress tolerance. This project uses transgenic plant technology to elucidate how mitochondrial function impacts on the profile of metabolites in plant cell and tissues and whether altering these profiles influences a plant's ability tog row in harsh conditions. It will contribute to our fundamental knowledge of plant metabolism using a metabolomic anaylsis of plant stress response. This will be achieved using new high-throughput technologies, allowing reliable qualitative and quantitative analysis of large numbers of samples. This approach will compliment existing genomic and proteomic analyses of plants exposed to abiotic stress.Read moreRead less
Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. T ....Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. This knowledge is highly relevant to any industry or research project utilising living organisms, as nutrient availability supports survival, cell growth and proliferation.Read moreRead less
Mechanisms Of Premature Cranial Fusion: Role Of Retinol Binding Protein 4 In Osteogenesis And Suture Fusion
Funder
National Health and Medical Research Council
Funding Amount
$555,855.00
Summary
Craniosynostosis is a condition where the skull bones fuse prematurely, affecting skull shape, vision and cognition. It occurs in 1 in 2,500 births. The only treatment is surgery, which is life-threatening, costly and may need to be repeated. By studying how fusion happens in this project we may be able to devise therapies to minimize the risks and need for re-operation. Here, we hope to show that modification of a single substance in the skull of mouse models can prevent premature bone fusion.
Overcoming Resistance to the Introduction of a Health Informatics System in General Practice Medicine. This project takes as its starting point the investigation of why medical practitioners in a rural community have been resistant to adopt a community based health information system designed to routinely collect, analyse and disseminate information regarding patient treatment. The project seeks to identify the deeper reasons for the resistance through analysis of the broader context of informat ....Overcoming Resistance to the Introduction of a Health Informatics System in General Practice Medicine. This project takes as its starting point the investigation of why medical practitioners in a rural community have been resistant to adopt a community based health information system designed to routinely collect, analyse and disseminate information regarding patient treatment. The project seeks to identify the deeper reasons for the resistance through analysis of the broader context of information systems in General Practice Medicine, with particular attention to the way Government health informatics initiatives fit with professional and practical priorities. The project will develop guidelines for acceptability of systems in this context and contribute to the broader knowledge management literature.Read moreRead less
The migration of cancer cells (metastasis) is responsible for most cancer deaths. Central to this is dynamic organisation of the actin cytoskeleton _ an internal structure that provides cell shape and enables movement. We have identified a family of small molecules (called miR-200) that regulates this actin cytoskeleton through specifically downregulating various genes. We are investigating the nature of these genes and their role in cell motility _ an underlying pre-requisite of metastasis.
Fish-Bird: Autonomous Interactions in a Contemporary Arts Setting. This research aims to investigate and expand the dialogical possibilities that exist between multiple autokinetic objects within a new media arts environment. Communication between the objects, and with their audience, will be explored through the modalities of gesture, motion and written text. A new aesthetic framework for interactive artwork will be created through research into autokinesis and the behavioural patterns that evo ....Fish-Bird: Autonomous Interactions in a Contemporary Arts Setting. This research aims to investigate and expand the dialogical possibilities that exist between multiple autokinetic objects within a new media arts environment. Communication between the objects, and with their audience, will be explored through the modalities of gesture, motion and written text. A new aesthetic framework for interactive artwork will be created through research into autokinesis and the behavioural patterns that evolve between people and autokinetic machines. Outcomes will include a major artwork in three stages, underpinned by a robotics software tool set that facilitates composition and experimentation with autokinetic artwork.Read moreRead less