Proteome Analysis of Plant Response Pathways to Microbial Signals in the Model Legume, Medicago truncatula. This project will investigate plant responses to soil microbes in the model legume, Medicago truncatula, to provide fundamental information needed to design crops with improved abilities to interact beneficially with soil microbes. Plant development and performance are significantly influenced by soil microbes, but it is largely unknown how the information contained in microbial signalling ....Proteome Analysis of Plant Response Pathways to Microbial Signals in the Model Legume, Medicago truncatula. This project will investigate plant responses to soil microbes in the model legume, Medicago truncatula, to provide fundamental information needed to design crops with improved abilities to interact beneficially with soil microbes. Plant development and performance are significantly influenced by soil microbes, but it is largely unknown how the information contained in microbial signalling molecules is relayed to plants. Proteome analysis and immunocytochemistry will be combined to identify and localise differentially expressed proteins in roots treated with specific microbial signal molecules. Annotated Proteome databases will be generated to strengthen and complement an international project on M. truncatula genome analysis.Read moreRead less
Does a novel class of small RNA molecules control self-incompatibility in solanaceous plants? Self-incompatibility is a simple and genetically defined cell recognition system that prevents inbreeding in many plant species. Flowers of self-incompatible plants can distinguish self pollen from foreign pollen, and allow only foreign pollen to fertilise their egg cells. This proposal will investigate the possibility that the part of the genetic self-incompatibility locus controlling recognition of ....Does a novel class of small RNA molecules control self-incompatibility in solanaceous plants? Self-incompatibility is a simple and genetically defined cell recognition system that prevents inbreeding in many plant species. Flowers of self-incompatible plants can distinguish self pollen from foreign pollen, and allow only foreign pollen to fertilise their egg cells. This proposal will investigate the possibility that the part of the genetic self-incompatibility locus controlling recognition of pollen is a novel type of gene that encodes a small RNA molecule but no protein. Knowledge gained by studying the self-incompatibility genes will help us to understand how plant cells recognise each other, and may allow us to manipulate seed (and hence crop) production.Read moreRead less
The great divergence, long-run growth and unified theories of economic growth. This project investigates why income has been close to subsistence levels for most of human history, and in particular, the factors that were responsible for take-off in Europe two centuries ago and then later in other countries. It is expected that both major and minor technological innovations have played a critical role in take-off.
Growth, IQ, diseases, and the great demographic transition. This project investigates firstly whether poor health and malnutrition among young children was a cause of severe cognitive impairment in the pre-industrialised West and in developing countries today, and secondly whether this has been a major factor behind the large disparities in income and growth over the 150 years since industrialisation.
Inequality, Trade, and Technology. This project aims to improve our understanding of the causes of rising income inequality in the world economy and in Australia since the early 1980s. We focus on the increasing building costs and imports of machinery as significant contributors to the increasing inequality. We hypothesize 1) that the increasing costs of buildings have reduced the demand for workers that are complementary to non-residential building capital; thus, reducing real wages; and 2) tha ....Inequality, Trade, and Technology. This project aims to improve our understanding of the causes of rising income inequality in the world economy and in Australia since the early 1980s. We focus on the increasing building costs and imports of machinery as significant contributors to the increasing inequality. We hypothesize 1) that the increasing costs of buildings have reduced the demand for workers that are complementary to non-residential building capital; thus, reducing real wages; and 2) that the marked increase in imports of machinery since the 1960s has reduced the demand for unskilled labour and widened the employment and wage gap between skilled and unskilled labour. Both factors may have driven the increasing inequality in Australia.
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Inequality and economic growth. This project aims to identify forces driving inequality. Piketty’s influential book, Capital in the 21st Century, stimulated research on inequality to address the increased public concern about inequality and its side-effects such as reduced growth. Piketty proposes three laws that explain and predict inequality paths over time, but there is no empirical evidence or theoretical foundations for these laws. This project will examine Piketty’s laws and investigate fa ....Inequality and economic growth. This project aims to identify forces driving inequality. Piketty’s influential book, Capital in the 21st Century, stimulated research on inequality to address the increased public concern about inequality and its side-effects such as reduced growth. Piketty proposes three laws that explain and predict inequality paths over time, but there is no empirical evidence or theoretical foundations for these laws. This project will examine Piketty’s laws and investigate factors that shape inequality and its relation to growth. This knowledge should enable Australian governments to reduce inequality and benefit economic growth, thereby reducing disadvantage and building stronger, more resilient communities.Read moreRead less
Adaptations of plant mitochondria during cold acclimation in Arabidopsis thaliana: towards an understanding of plant cold acclimation. Frost damage is a major cost to agricultural producers and some crop plant species needlessly adapt to cold, when they are grown in temperate regions or in glasshouses, which leads to decreased production. The principal outcome of this project will be to greatly extend our knowledge about plant mitochondrial responses to environmental cold stress and what role th ....Adaptations of plant mitochondria during cold acclimation in Arabidopsis thaliana: towards an understanding of plant cold acclimation. Frost damage is a major cost to agricultural producers and some crop plant species needlessly adapt to cold, when they are grown in temperate regions or in glasshouses, which leads to decreased production. The principal outcome of this project will be to greatly extend our knowledge about plant mitochondrial responses to environmental cold stress and what role they have in helping plants adapt to environmental change. An understanding of cold acclimation may allow the production of plants with altered cold acclimation phenotypes and greater frost tolerance.Read moreRead less
Novel cell wall genes ripe for the picking. This project aims to investigate the role of recently discovered plant cellulose synthase-like CslM genes and to define the polysaccharide product associated with them. Successful identification of the polysaccharide is highly likely to increase our fundamental understanding of how cell walls are made, how cells stick together or fall apart as well as facilitating the training of the next generation of cell wall biologists in challenging molecular and ....Novel cell wall genes ripe for the picking. This project aims to investigate the role of recently discovered plant cellulose synthase-like CslM genes and to define the polysaccharide product associated with them. Successful identification of the polysaccharide is highly likely to increase our fundamental understanding of how cell walls are made, how cells stick together or fall apart as well as facilitating the training of the next generation of cell wall biologists in challenging molecular and biochemical techniques. This new knowledge could increase our understanding of fruit ripening, and how it might be manipulated. This could have significant downstream commercial benefits if applied to breeding programs of economically important fruit such as grapes, tomatoes and strawberries.Read moreRead less
Predicting cell wall mechanics from structure in a materials engineering approach to plant growth. The project fosters a novel, interdisciplinary approach to understanding how the structure of plant cell walls determines their mechanical properties. Such understanding requires combining biological and engineering approaches and will illuminate how plants grow and produce cells and organs with particular shapes. This is scientifically important but is also important for industries depending on sp ....Predicting cell wall mechanics from structure in a materials engineering approach to plant growth. The project fosters a novel, interdisciplinary approach to understanding how the structure of plant cell walls determines their mechanical properties. Such understanding requires combining biological and engineering approaches and will illuminate how plants grow and produce cells and organs with particular shapes. This is scientifically important but is also important for industries depending on specialised cell shapes such as those of cotton and wood fibres. Our work will improve our understanding of how wall structure determines fibre and other cell shapes and give us tools which can be used to understand how final wall structure determines the fibre mechanics on which industrial users depend. Read moreRead less
Elucidation of the hierarchy of stem, progenitor and mature cells in the mouse mammary gland. Breast cancer is the most common cause of cancer-related death in women in Australia. Although the treatments have improved over the last 30 years, many women still die from the disease. It is therefore important to identify new targets for breast cancer treatment. There is growing interest in the concept that a cancer-initiating cell may arise from a stem cell or progenitor cell in the mammary gland. O ....Elucidation of the hierarchy of stem, progenitor and mature cells in the mouse mammary gland. Breast cancer is the most common cause of cancer-related death in women in Australia. Although the treatments have improved over the last 30 years, many women still die from the disease. It is therefore important to identify new targets for breast cancer treatment. There is growing interest in the concept that a cancer-initiating cell may arise from a stem cell or progenitor cell in the mammary gland. Our goal is to identify those cells and to determine which genes are involved in transforming a normal cell to a cancerous cell.Read moreRead less