Investigating B Cell Development, Maintenance And High-affinity Antibody Production By ENU Mutagenesis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
B cells are essential for the protection against infections. This application aims to identify new genes that are crucial for the development or function of B cells and will investigate how mutations in newly discovered genes contribute to defects in the development and function of B cells and the pathogenesis of B cell leukaemia.
Dissecting The Molecular Mechanisms During Reprogramming Of Different Somatic Cells Into Induced Pluripotent Stem Cells And The Plasticity Potential Of Their Intermediate Stages.
Funder
National Health and Medical Research Council
Funding Amount
$234,965.00
Summary
I am a biochemist interested in the molecular mechanisms involved in gene expression and how these processes govern cell identity. I use a combination of mouse models, biochemical techniques and bioinformatics to study the _reprogramming� of adult cells into embryonic stem-like cells and how this technology can be used to generate different cell types for use in cellular replacement therapies and drug screening.
Competition For Polarity Influences Lymphocyte Differentiation And Function
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
CD46 is a protein on human cells that viruses and bacteria bind to during infection. Our laboratory has found that binding of CD46 on immune cells impairs their ability to recognize and kill target cells and may explain the immunosuppression caused by measles infection. We aim to investigate the mechanisms behind the effect of CD46 on immune cells. The outcomes of this study will define new paradigms in lymphocyte biology and determine how CD46 influences the immune response to infection.
Using Human 3D Engineered Heart Tissue For Discovery Of Novel Biology And Novel Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
The goal of this project is to develop a model of miniaturised 3D human heart tissue for research into cardiac biology and also drug discovery applications. This will hopefully result in better, cheaper drugs in the future with less reliance on animal testing.
Nfi Genes Regulate The Switch Between Neurogenesis And Gliogenesis During Cortical Development
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Cells within the brain fall into two categories; neurons or glia. Importantly, both derive from a common progenitor population, the radial glia, during development. Early in development radial glia produce neurons, while later they generate glia. The genes which control the switch from neuron production to glia production remain poorly defined. I propose to investigate how this switch is controlled in radial glia, focussing on a family of proteins known to regulate gene transcription.
Understanding ILC1 Transcriptional Regulation And Function In Immune Protection
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Natural killer cells are innate cells that provide first line defense against infection and cancer. The recent discovery of a novel innate cell population has modified our vision of the early events necessary for immune protection. Understanding the role of these cells is critical as they could represent viable therapeutic targets. We have developed unique mouse models to experimentally target this population to determine how they are generated and their role in combating infection and cancer.