Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100183
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Protein Quantitation Centre of South Australia renewal for Systems Biology. This application aims to renew Mass Spectrometry (MS) instrumentation to characterise and quantify Biomolecules towards a better understanding of biological processes. UniSA, Uni Adelaide, Flinders have established the Protein Quantitation Centre of South Australia (PQCSA) in 2013 through an ARC LIEF lead by CI Hoffmann and this application will renew and expand MS capacity towards metabolites, glycans and lipids. This ....Protein Quantitation Centre of South Australia renewal for Systems Biology. This application aims to renew Mass Spectrometry (MS) instrumentation to characterise and quantify Biomolecules towards a better understanding of biological processes. UniSA, Uni Adelaide, Flinders have established the Protein Quantitation Centre of South Australia (PQCSA) in 2013 through an ARC LIEF lead by CI Hoffmann and this application will renew and expand MS capacity towards metabolites, glycans and lipids. This will enable researchers in South Australia to work towards a full understanding of biological processes and towards expanding their knowledge to Systems Biology. Expected outcome of the projects are multiple interdisciplinary collaborations between the CI's and should provide significant benefits in research outputs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100155
Funder
Australian Research Council
Funding Amount
$909,079.00
Summary
Advancing 4D fluorescence microscopy within Australia. This multi-institutional proposal aims to establish a state-of-the-art Lightsheet microscope facility in South Australia with enhanced analysis infrastructure and a national user support network. Expectations are, this will transform researcher outcomes for multiple disciplines by facilitating high-resolution four-dimensional interrogation of novel biological processes. Significant benefits will include the ability to image deep within livin ....Advancing 4D fluorescence microscopy within Australia. This multi-institutional proposal aims to establish a state-of-the-art Lightsheet microscope facility in South Australia with enhanced analysis infrastructure and a national user support network. Expectations are, this will transform researcher outcomes for multiple disciplines by facilitating high-resolution four-dimensional interrogation of novel biological processes. Significant benefits will include the ability to image deep within living tissue over long time-scales without inducing phytotoxicity to produce high-impact fundamental and translatable outcomes, the development of novel probes and methodologies, new cross-disciplinary collaborations, and new and unique funding, student training and public engagement opportunities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100174
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
Development of a digital Transmission Electron Microscope Facility in Tasmania. Development of a digital transmission electron microscope facility: Transmission electron microscopy is a fundamental tool for the study of biological systems at the ultrastructural level. This project will establish a facility that will be accessible to a range of biological researchers, replacing aged and non-sustainable electron microscopy facilities. The instrument will revitalise cellular research and provide ad ....Development of a digital Transmission Electron Microscope Facility in Tasmania. Development of a digital transmission electron microscope facility: Transmission electron microscopy is a fundamental tool for the study of biological systems at the ultrastructural level. This project will establish a facility that will be accessible to a range of biological researchers, replacing aged and non-sustainable electron microscopy facilities. The instrument will revitalise cellular research and provide additional insights and outcomes related to the study of intracellular features in a diverse range of systems and models. This will add substantially to the knowledge base across a wide range of fields of research, increasing national contributions in the areas of neuroscience, separation science and marine science.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100075
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility wh ....Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility while reducing cost. The expected benefits will advance the elucidation of molecular mechanisms involved in complex biological phenomena. The benefits of this are substantial, including reduction in test compound and reagents, which in turn reduces laboratory costs, conserves cells and increases data quality.Read moreRead less
Global differentiation of the conifer flora. Conifers are among the most widely recognised and well-loved group of plants. This project will place a global perspective on the evolutionary significance of the southern conifers. Furthermore conifers such as the Wollemi Pine, bunyas, kauris and huon pine are of considerable ecotourism value, and this project will provide a basis for interpretation of these important plants.
Special Research Initiatives - Grant ID: SR0354787
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Research Network for Biotechnological and Environmental Applications of Microalgae (BEAM). The network will facilitate inderdisciplinary and collaborative research into the limitations on microalgal growth leading to the development of new, commercial-scale microalgae culture systems, the production of fine chemicals, bioactive compounds and renewable fuels (hydrogen), as well as environmental applications such as monitoring the physiological state of phytoplankton in the environment, CO2 biorem ....Research Network for Biotechnological and Environmental Applications of Microalgae (BEAM). The network will facilitate inderdisciplinary and collaborative research into the limitations on microalgal growth leading to the development of new, commercial-scale microalgae culture systems, the production of fine chemicals, bioactive compounds and renewable fuels (hydrogen), as well as environmental applications such as monitoring the physiological state of phytoplankton in the environment, CO2 bioremediation and algal/bacterial systems for the bioremediation of contaminated soils. This will be achieved by applying research on photosynthetic light utilisation efficiency and carbon fixation, chlorophyll fluorescence, biochemistry of secondary metabolites, molecular biology and photobioreactor design and engineering, informed by an understanding of the ecology of these algae.Read moreRead less
Why our biota is unique: ecophysiological response, adaptive radiation and changing environments in Cainozoic Australia. We seek to resolve Cainozoic diversification and extinction patterns leading to the modern Australian biota. We propose a broad-scale, multi-disciplinary approach involving systematic palaeontology, palaeobiology, biostratigraphy, molecular and morphological systematics and physiology of modern organisms. For the first time, we will synthesise data on past climatic and environ ....Why our biota is unique: ecophysiological response, adaptive radiation and changing environments in Cainozoic Australia. We seek to resolve Cainozoic diversification and extinction patterns leading to the modern Australian biota. We propose a broad-scale, multi-disciplinary approach involving systematic palaeontology, palaeobiology, biostratigraphy, molecular and morphological systematics and physiology of modern organisms. For the first time, we will synthesise data on past climatic and environmental influences on the evolution of Australian plants, animals and community structure through time. This will provide a solid historical basis to develop management strategies for the Australian biota under different, future, climatic scenarios, and will also provide a biostratigraphic framework essential for high-resolution mineral and hydrocarbon exploration.Read moreRead less
Range dynamics and demographics of spatially structured populations under global change. Why are particular species present in some locations, but not others? This is a simple, fundamental ecological question, yet surprisingly, our answers on this point remain far from complete. Using an integrated, systems-based approach, we will determine the interplay between: (i) birth, death and movement rates, (ii) species interactions, and (iii) the constraints of the physical environment (temperature, ra ....Range dynamics and demographics of spatially structured populations under global change. Why are particular species present in some locations, but not others? This is a simple, fundamental ecological question, yet surprisingly, our answers on this point remain far from complete. Using an integrated, systems-based approach, we will determine the interplay between: (i) birth, death and movement rates, (ii) species interactions, and (iii) the constraints of the physical environment (temperature, rainfall, soil type), which determine the limits of species' ranges. Our models will provide Australian conservation managers with a novel, validated toolbox to explore the trade-offs, and synergies, inherent in trying to adapt to climate change and other stressors on biodiversity.Read moreRead less
Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
Reconstructing past population dynamics to understand human and climatic impacts in prehistory. More than 100 species have become extinct since humans first colonised Australia, and over 1000 are considered threatened. This research will determine the factors most strongly governing the interaction between humans and native fauna in Australia over the last 46 millennia. Our approach is powerful and novel because it will effectively draw together multidisciplinary evidence on natural resource exp ....Reconstructing past population dynamics to understand human and climatic impacts in prehistory. More than 100 species have become extinct since humans first colonised Australia, and over 1000 are considered threatened. This research will determine the factors most strongly governing the interaction between humans and native fauna in Australia over the last 46 millennia. Our approach is powerful and novel because it will effectively draw together multidisciplinary evidence on natural resource exploitation and habitat alteration by ancient people, and the influence of dramatic climatic shifts on the Australian biota. Information on past biological responses to environmental change is critical to properly contextualising the current impact, and long-term consequences of, threats such as global warming, habitat loss and invasive species.Read moreRead less