Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100202
Funder
Australian Research Council
Funding Amount
$255,120.00
Summary
Three-dimensional cryo correlative light and electron microscopy facility. This project aims to establish a three-dimensional (3D) cryo-correlative light and electron microscopy facility. The facility will integrate light microscopy with high resolution cryo-electron tomography and 3D slice-and-view focused ion beam scanning electron microscopy. The open access facility should create new capabilities for Australian researchers to tag biological events and structures with fluorescence markers and ....Three-dimensional cryo correlative light and electron microscopy facility. This project aims to establish a three-dimensional (3D) cryo-correlative light and electron microscopy facility. The facility will integrate light microscopy with high resolution cryo-electron tomography and 3D slice-and-view focused ion beam scanning electron microscopy. The open access facility should create new capabilities for Australian researchers to tag biological events and structures with fluorescence markers and image them using the currently highest resolution 3D imaging techniques for biological matter. The facility expects to reveal fundamental insights into cell and structural biology, and help drive innovation in agriculture, pharmaceutics, and biomaterials.Read moreRead less
Transcription factor nuclear residency as a driver of gene expression. Persistently active proteins can stay in the nucleus to drive cell growth and prevent cell death. This project will define how one specific active protein can remain in the nucleus and regulate gene expression through the action of unique ribonucleic acid (RNA) molecules. The results will enable persistent gene activation to be manipulated in cancer.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100011
Funder
Australian Research Council
Funding Amount
$346,439.00
Summary
Spinning disk confocal microscope with dual stages. Spinning disk confocal microscope with dual stages: This custom-built spinning disk confocal microscope with rotational stages will constitute an internationally unique platform. The system has the capability of rapidly monitoring cells in growing biological specimens under changing environments. It offers an integrated platform for multiple imaging strategies, including confocal and Total Internal Reflection Fluorescence (TIRF) microscopy. The ....Spinning disk confocal microscope with dual stages. Spinning disk confocal microscope with dual stages: This custom-built spinning disk confocal microscope with rotational stages will constitute an internationally unique platform. The system has the capability of rapidly monitoring cells in growing biological specimens under changing environments. It offers an integrated platform for multiple imaging strategies, including confocal and Total Internal Reflection Fluorescence (TIRF) microscopy. The system will reside in core facilities with open access to a broad research community. The system may be used to monitor a wide variety of cells and molecules, and will offer capabilities that are of importance to understand cell trafficking, disease and signalling, plant biomass production, and climate change.Read moreRead less