Characterising Signals Important For Lymphangiogenesis During Development And Disease.
Funder
National Health and Medical Research Council
Funding Amount
$604,938.00
Summary
Lymphatic vessels are a vital component of the cardiovascular system. Abnormalities in the growth and development of lymphatic vessels are associated with human disorders including cancer, lymphoedema and inflammatory diseases. The focus of this application is to characterise signals that direct the construction of lymphatic vessels, with the aim of identifying targets to which novel therapeutics for the treatment of lymphatic vascular diseases could be generated.
Novel Methods For Promoting Organ Development And Growth
Funder
National Health and Medical Research Council
Funding Amount
$390,203.00
Summary
A revolutionary new therapy for treatment of growth restricted fetuses and premature babies is being developed through the administration of Colony Stimulating Factor (CSF-1). We have evidence that CSF-1 therapy can promote kidneys and lungs to continue development and maturation after birth. This exciting new finding allows for the application of CSF-1 therapy for both the treatment of premature babies and unborn babies with kidney defects.
Priming The Maternal Immune Response To Resist Inflammatory Disorders Of Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$920,972.00
Summary
Preeclampsia and preterm birth are common conditions affecting >15 million pregnancies annually. An underlying cause is the mother’s immune response, which can react adversely to the fetus causing an inflammatory reaction. This project seeks to find ways to strengthen the maternal immune system beginning before conception. The work will provide insights upon which to advise intending parents and will inform development of new treatments options to protect susceptible women.
Regulation Of VEGFR Trafficking And Signal Transduction By The Ubiquitin Ligase Nedd4
Funder
National Health and Medical Research Council
Funding Amount
$388,347.00
Summary
Our recent work has discovered that the Nedd4 gene is crucial for the growth and development of blood vessels and lymphatic vessels. Our data suggest that Nedd4 controls vessel growth by regulating the levels and signalling activity of the key vascular growth factor receptors VEGFR-2 and VEGFR-3. The goals of this proposal are to define precisely how Nedd4-1 regulates the activity of these receptors and how VEGFR signalling could be better targeted to treat vascular disorders.
Embryo genomics for engineering change. The proposed research program will contribute to areas that are critically important for Australia, such as agriculture, animal biodiversity, biomedicine, human health and biosafety. By addressing the high economic losses due to early embryonic mortality in farm animals, results from this research will enhance the competitiveness of Australian agriculture and biomedical research. The establishment of a world class research Centre for Animal Biotechnology a ....Embryo genomics for engineering change. The proposed research program will contribute to areas that are critically important for Australia, such as agriculture, animal biodiversity, biomedicine, human health and biosafety. By addressing the high economic losses due to early embryonic mortality in farm animals, results from this research will enhance the competitiveness of Australian agriculture and biomedical research. The establishment of a world class research Centre for Animal Biotechnology at the University of Adelaide will create a major addition to the national research base. The Centre will develop technology platforms to support various groups across the entire Australian scientific community.Read moreRead less
Special Research Initiatives - Grant ID: SR200200446
Funder
Australian Research Council
Funding Amount
$247,058.00
Summary
Rebuilding Troubled Regions: The Difference that Space Makes. This project aims to examine economic restructuring processes focusing on the parts of regional Australia that are being left behind by globalisation. The project will examine patterns of firm entry and exit in disadvantaged local economies following major plant closures and identify the causal pathways associated with sustainable employment and industry growth. The project will deploy the innovative methodology of Qualitative Compara ....Rebuilding Troubled Regions: The Difference that Space Makes. This project aims to examine economic restructuring processes focusing on the parts of regional Australia that are being left behind by globalisation. The project will examine patterns of firm entry and exit in disadvantaged local economies following major plant closures and identify the causal pathways associated with sustainable employment and industry growth. The project will deploy the innovative methodology of Qualitative Comparative Analysis and utilise recently developed datasets with a view to isolating causal relationships. By generating new knowledge about how space, positioning, and state interventions temper the nature and form of business births and deaths, the project will generate new regional policy insights and approaches.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101132
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
How social relationships improve sheep productivity. This project aims to determine how the social network structure of a flock and different individuals’ experience and leadership abilities improve a population’s well-being and productivity (wool clip and lambing rates). This project will use social network theory and collective behaviour in animals to manage sheep in Australia’s arid rangelands, which are important for the pastoral industry, but where ecological challenges reduce livestock pro ....How social relationships improve sheep productivity. This project aims to determine how the social network structure of a flock and different individuals’ experience and leadership abilities improve a population’s well-being and productivity (wool clip and lambing rates). This project will use social network theory and collective behaviour in animals to manage sheep in Australia’s arid rangelands, which are important for the pastoral industry, but where ecological challenges reduce livestock productivity. An expected outcome is management guidelines for the sheep industry to improve wool and meat production.Read moreRead less
Economic complexity as a driver of innovation and smart specialisation. This project aims to determine how economic complexity can drive innovation and smart specialisation and how industry can be supported to transition to a more competitive economy. With the downturn of traditional manufacturing, innovation is crucial to create new industries and the jobs of the future. The expected outcomes of this project include high-value industry intelligence in support of product diversification. This sh ....Economic complexity as a driver of innovation and smart specialisation. This project aims to determine how economic complexity can drive innovation and smart specialisation and how industry can be supported to transition to a more competitive economy. With the downturn of traditional manufacturing, innovation is crucial to create new industries and the jobs of the future. The expected outcomes of this project include high-value industry intelligence in support of product diversification. This should provide significant benefits, such as increased international competitiveness, exports, revenue, and economic growth.
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Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e ....Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e-skin) sensors, which are wearable for monitoring blood pulses, body motions and hand gestures in real-time and in situ. This is expected to advance our knowledge in nanotechnology and generate patentable technologies in soft e-skin sensors, and to bring significant scientific and economic gains to Australia.Read moreRead less
Metabolite glucosylation during grape berry development. The research proposed contributes to building and transforming the Australian wine industry, and other horticultural industries, by developing expertise and knowledge in the area of grape berry metabolism. The synthesis and validation of a library of grape berry metabolites, annotation of part of the grapevine genome sequence dataset and development of the micro vine transformation system are innovative products of significant national and ....Metabolite glucosylation during grape berry development. The research proposed contributes to building and transforming the Australian wine industry, and other horticultural industries, by developing expertise and knowledge in the area of grape berry metabolism. The synthesis and validation of a library of grape berry metabolites, annotation of part of the grapevine genome sequence dataset and development of the micro vine transformation system are innovative products of significant national and international benefit. Two high-quality PhD students will be trained in a collaborative and high-quality research environment during the course of the proposed research.Read moreRead less