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The Effect Of Aging On Cardiovascular Disease Prediction
Funder
National Health and Medical Research Council
Funding Amount
$96,293.00
Summary
Cardiovascular disease is a leading cause of death and disability in the elderly. We aim to investigate: (i) the ability of traditional CVD risk factors to predict major adverse cardiovascular events (MACE) in the elderly and their interaction with frailty (ii) the ability of plaque burden on CT coronary angiogram to predict MACE in older populations and its incremental predictive value compared to traditional risk scoring (iii) whether platelet activation pathways differ with increasing age
Remote Ischaemic Preconditioning And Its Effect On Coronary Physiology And Platelet And Leukocyte Activation.
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
Remote ischaemic preconditioning (RIPC) is a novel treatment which can improve patient outcomes after a heart attack, undergoing coronary stenting or bypass surgery. The mechanisms by which RIPC confers this cardio-protection is not clear. We will study the effects of RIPC on platelet activity and the flow of blood in the arteries that supply the heart. Understanding RIPC may open new avenues for treatment of patients with coronary artery disease, one of the major causes of death in Australia.
A Novel Device To Improve Renal Blood Flow In Cardiorenal Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$198,900.00
Summary
The aim of this project is to assist in the development of a novel device to treat poor delivery of blood to the kidneys in conditions such as heart muscle weakness (chronic heart failure, CHF). Specifically we aim to build a prototype and test the device in a relevant animal model of CHF. Chronic heart failure is a major public health problem affecting >10% of the adult population over the age of 60 years. It is associated with high morbidity, mortality, frequent hospitalisation and major co ....The aim of this project is to assist in the development of a novel device to treat poor delivery of blood to the kidneys in conditions such as heart muscle weakness (chronic heart failure, CHF). Specifically we aim to build a prototype and test the device in a relevant animal model of CHF. Chronic heart failure is a major public health problem affecting >10% of the adult population over the age of 60 years. It is associated with high morbidity, mortality, frequent hospitalisation and major cost burden on the public health system. Weak heart muscle results in poor delivery of blood to the kidneys. Poor delivery to the kidneys activates circulating hormones which in turn further impair cardiac function by adverse effects on the heart. We have developed and patented a novel catheter based system for improvement of renal function via a purpose built device. Proof-of-concept studies have shown that the device should improve kidney blood flow in the setting of CHF. Given the huge public health problem of heart failure and the importance of the kidney in this setting, the commercial potential for a simple device that can be positioned via a catheter-based approach, permanently implanted is large. The device is currently being constructed by the Monash University Department of Engineering where expertise exists with regard to biomedical devices and materials engineering. A series of proof-of-concept studies will then be performed in sheep, as the vasculature of the sheep roughly approximates the dimensions of man. Sheep with CHF will have the device inserted percutaneously into the aorta. Measurements will be made of renal artery flow, relevant circulatory hormones and ultrasound of the heart at baseline (pre-deployment) and following deployment. We believe the above studies (should they be successful) will be sufficient to constitute definitive proof-of-concept and thus allow the device to be commercialised, most likely by a licensing arrangement with a device company.Read moreRead less
Physiology Of Acute Coronary Syndromes: Focus On Microvascular Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$90,029.00
Summary
Heart attacks,caused by blocked coronary arteries are an important public health concern.There are patients who have a worse outcome due to damage of small blood vessels that cannot be visualised with normal testing. New blood tests and invasive technology are available that can assess these small vessels.We plan to use these techniques to observe the extent of small blood vessel damage in patients with heart attacks and hope this will lead to better understanding of heart attacks and improved t ....Heart attacks,caused by blocked coronary arteries are an important public health concern.There are patients who have a worse outcome due to damage of small blood vessels that cannot be visualised with normal testing. New blood tests and invasive technology are available that can assess these small vessels.We plan to use these techniques to observe the extent of small blood vessel damage in patients with heart attacks and hope this will lead to better understanding of heart attacks and improved treatments.Read moreRead less
Studying Coronary Physiology Within Human Coronary Arteries Using Computational Fluid Dynamics
Funder
National Health and Medical Research Council
Funding Amount
$383,834.00
Summary
The aim of this project is to combine the recent technological advances within the individual fields of coronary physiology, three-dimensional coronary angiography, and computational fluid dynamics to develop a novel method to calculate realistic coronary blood flow. This technique will provide a simple and clinically applicable method to measure physiological parameters such as microcirculatory resistance and shear stress within _live� human coronary arteries.