Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia ....Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia from invasive diseases. There is an urgency to undertake our research because global environmental change and increasing movements of people (particularly military personnel) from overseas regions where these diseases are endemic is increasing the vulnerability of northern Australia to the (re)establishment of mosquito borne diseases.Read moreRead less
The endangered swift parrot as a model for managing small migratory birds. Endangered swift parrots use variable locations while breeding in eastern Tasmania and over winter on the Australian mainland. This project aims to develop effective conservation strategies for swift parrots and other migrants using new and long term data and innovative technological solutions to tracking small birds across vast landscapes.
Reasonable Adjustments to Maths for Students with Intellectual Disabilities. Reasonable adjustments to secondary mathematics – parents want it, students need it, the Australian law requires it – but how do teachers achieve it? The aim of this project is to find ways to adjust, teach and assess secondary mathematics for students with intellectual and developmental disabilities. The significance of this study is in solving a problem facing teachers who are required by law to teach mathematics with ....Reasonable Adjustments to Maths for Students with Intellectual Disabilities. Reasonable adjustments to secondary mathematics – parents want it, students need it, the Australian law requires it – but how do teachers achieve it? The aim of this project is to find ways to adjust, teach and assess secondary mathematics for students with intellectual and developmental disabilities. The significance of this study is in solving a problem facing teachers who are required by law to teach mathematics without evidence informed approaches. Expected outcomes are an evidence-base for reasonable adjustments to secondary mathematics and approaches and strategies for teachers for inclusive practices. If ways for teaching year-level mathematics to learners with intellectual disability are developed, many more students may benefit.
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Technology and innovation management in high risk situations. The value of Australian bulk commodity exports and container imports is expected to double from $400 billion to $800 billion by 2020, placing considerable pressure on port waters. This project will examine the challenge whereby port operators are both encouraged to take risks to innovate but are constrained by the consequences of risk.
Evolution. Morphodynamics and History of the Younghusband Peninsula. This project will examine the history and evolution of the Sir Richard-Younghusband Peninsula (SRYP) complex barrier in SA. The aims are to derive a understanding of how the influences of relative sea-level changes, neotectonics, and sediment supply, can produce remarkably different responses in barrier development. No complex barrier (i.e. foredune ridges in one portion, transgressive dunefields in another) has ever been compr ....Evolution. Morphodynamics and History of the Younghusband Peninsula. This project will examine the history and evolution of the Sir Richard-Younghusband Peninsula (SRYP) complex barrier in SA. The aims are to derive a understanding of how the influences of relative sea-level changes, neotectonics, and sediment supply, can produce remarkably different responses in barrier development. No complex barrier (i.e. foredune ridges in one portion, transgressive dunefields in another) has ever been comprehensively drilled, dated, modelled, or examined in the context of indigenous occupation and oral histories in Australia. The study provides excellent analogues for barrier and dune response, and shoreline translation to varying rates of sea level rise, paralleling pressures facing all coastlines today.Read moreRead less
How isolated is Antarctica? Assessing past and present plant colonisations. The project aims to assess how biologically isolated Antarctica is by discovering how, when and where natural colonisations of the continent have occurred. The research will focus on mosses, the dominant plant group in the Antarctic. genomic tools will be combined with environmental, spatial, and ecological data to assess mechanisms and directions of dispersal to and around Antarctica, and to predict areas most likely to ....How isolated is Antarctica? Assessing past and present plant colonisations. The project aims to assess how biologically isolated Antarctica is by discovering how, when and where natural colonisations of the continent have occurred. The research will focus on mosses, the dominant plant group in the Antarctic. genomic tools will be combined with environmental, spatial, and ecological data to assess mechanisms and directions of dispersal to and around Antarctica, and to predict areas most likely to be colonised in the future. This will help understand the processes underpinning the evolution and diversity of Antarctic species, and the vulnerability and adaptability of Antarctic ecosystems. Read moreRead less
Religious freedom, LGBT+ employees, and the right to discriminate. This research aims to identify constructive strategies to manage religious freedom and LGBT+ rights in religiously affiliated workplaces in education, health care, and social welfare. The project will carefully describe workplace experiences, religious beliefs, and current legislation associated with religious freedom and LGBT+ rights. It will evaluate different policies and managerial practices in terms of their impact on religi ....Religious freedom, LGBT+ employees, and the right to discriminate. This research aims to identify constructive strategies to manage religious freedom and LGBT+ rights in religiously affiliated workplaces in education, health care, and social welfare. The project will carefully describe workplace experiences, religious beliefs, and current legislation associated with religious freedom and LGBT+ rights. It will evaluate different policies and managerial practices in terms of their impact on religious practitioners and LGBT+ workers. The research combines systematic empirical research with legal and philosophical analysis. It will produce findings that policy makers and religiously affiliated social service providers can immediately use to guide their responses to religious freedom and LGBT+ rights.Read moreRead less