Elucidating the post-transcriptional regulation of mast cell proteases. Mast cells (MCs) are immune cells that protect against pathogens but may induce deleterious inflammation. MC function is mediated by specific proteases that are pre-formed and stored in granules. These proteases have unique yet poorly understood mechanisms of regulation. The aim of the project is to use a novel suite of molecular tools and genetically modified mice to identify the critical regions of transcripts that post-tr ....Elucidating the post-transcriptional regulation of mast cell proteases. Mast cells (MCs) are immune cells that protect against pathogens but may induce deleterious inflammation. MC function is mediated by specific proteases that are pre-formed and stored in granules. These proteases have unique yet poorly understood mechanisms of regulation. The aim of the project is to use a novel suite of molecular tools and genetically modified mice to identify the critical regions of transcripts that post-transcriptionally regulate the production and storage of these proteins. The project aims to identify the RNA binding proteins, microRNAs and other novel factors that also regulate them. This is expected to elucidate the post-transcriptional mechanisms of regulation of MC proteases.Read moreRead less
In-vivo detection of airway injury and disease using phase contrast X-ray velocimetry. Currently diagnosis of lung disease, a major cause of death in humans, is based on clinical symptoms that do not usually manifest until the disease is well advanced. This project will develop a novel imaging technique, X-ray velocimetry, to detect changes in tissue before symptoms arise, potentially leading to strategies for managing lung diseases.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100043
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Development of an ultra-high speed spinning disk confocal micro-particle image velocimetry (PIV) platform for the investigation of cardiovascular disease . This facility will establish a microscope system specifically designed to investigate the function of blood cells in the context of cardiovascular diseases such as heart attack and stroke.
Accelerated Finite-time Learning and Control in Cyber-Physical Systems. Efficient learning and control in cyber-physical systems such as smart grids and robotic systems are very important for achieving economic and social benefits. This project aims to establish a breakthrough accelerated finite-time dynamics theory and technology to assist in delivering efficient learning and control. Expected outcomes include new distributed accelerated finite-time dynamics based learning and control algorithm ....Accelerated Finite-time Learning and Control in Cyber-Physical Systems. Efficient learning and control in cyber-physical systems such as smart grids and robotic systems are very important for achieving economic and social benefits. This project aims to establish a breakthrough accelerated finite-time dynamics theory and technology to assist in delivering efficient learning and control. Expected outcomes include new distributed accelerated finite-time dynamics based learning and control algorithms and tools for optimal operations in cyber-physical systems. This should provide significant benefits including a practical technology for industry applications in smart grids and robotic systems, and training of the next generation engineers in this technology for Australia.Read moreRead less
Protecting Occupants in Vehicle Rollover Crashes. This project addresses a public health issue involving rollover crashes. It will help prevent 340 deaths, 6000 injuries and save $3.6 billion annually in Australia and many fold this number internationally. A dynamic rollover crashworthiness test protocol, that ensures efficient and economical vehicle rollover protection systems are designed and manufactured, will be provided to consumer and regulatory bodies to consider and implement. In additio ....Protecting Occupants in Vehicle Rollover Crashes. This project addresses a public health issue involving rollover crashes. It will help prevent 340 deaths, 6000 injuries and save $3.6 billion annually in Australia and many fold this number internationally. A dynamic rollover crashworthiness test protocol, that ensures efficient and economical vehicle rollover protection systems are designed and manufactured, will be provided to consumer and regulatory bodies to consider and implement. In addition, much needed Occupational Health & Safety information regarding vehicle rollover crashworthiness, which provide a safe work place environment for professional drivers and employees using vehicles, will be supplied to industry fleet managers, defence and emergency services.Read moreRead less
Non-contact Integrity Assessment of Façade Panels of High-rise Buildings. Disintegration of the external façade (with tiles, plates, etc.) of high-rise buildings presents a great challenge and a threat to community. This project develops fundamental knowledge and algorithms that underpin the deployment of a new technique for fast and automated quantitative integrity assessment of façade units of high-rise buildings, integrating mechanisms of directional acoustic waves, vibro-acoustics of façade ....Non-contact Integrity Assessment of Façade Panels of High-rise Buildings. Disintegration of the external façade (with tiles, plates, etc.) of high-rise buildings presents a great challenge and a threat to community. This project develops fundamental knowledge and algorithms that underpin the deployment of a new technique for fast and automated quantitative integrity assessment of façade units of high-rise buildings, integrating mechanisms of directional acoustic waves, vibro-acoustics of façade tiles or panels, laser sensing technology, deep learning algorithms and drone technology. Outcomes of this project are critical for implementing the new technology for enhanced safety to community and the development of new procedures for driving down maintenance costs of the external façade of high-rise buildings.Read moreRead less
Comfort and ergonomics: Innovative seating solutions for commercial vehicles. Comfort and ergonomics: Innovative seating solutions for commercial vehicles. This project aims to develop a 6-degree-of-freedom seating system for commercial vehicles, including heavy duty trucks and mobile machinery, to reduce unwanted multiple directional vibrations to the driver’s body. Long-term exposure to vibrations from uneven road surfaces, vibrating tools, and vibrating machinery affects driver comfort, fatig ....Comfort and ergonomics: Innovative seating solutions for commercial vehicles. Comfort and ergonomics: Innovative seating solutions for commercial vehicles. This project aims to develop a 6-degree-of-freedom seating system for commercial vehicles, including heavy duty trucks and mobile machinery, to reduce unwanted multiple directional vibrations to the driver’s body. Long-term exposure to vibrations from uneven road surfaces, vibrating tools, and vibrating machinery affects driver comfort, fatigue and safety, and can also cause neck and shoulder pain, lower back injuries, and spinal injuries. The expected outcome of the project is a comfortable and ergonomic seating system that, agriculture, transportation, mining and construction vehicles, both in Australia and internationally, can widely use.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100003
Funder
Australian Research Council
Funding Amount
$4,930,205.00
Summary
ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and devel ....ARC Training Centre for Biofilm Research and Innovation . The ARC Training Centre for Biofilm Research and Innovation aims to transform biofouling management strategies for maritime platforms by building on local and international expertise to mentor and train the next generation of interdisciplinary scientists and engineers. Anticipating evolving regulatory stringency, this project expects to establish a dynamic environment for industry partners, students and scientists to collaborate and develop biofilm management strategies. Expected outcomes include new and enhanced collaborations that advance and translate knowledge to better manage biofouling. The significant benefits will include a generation of industry-focused researchers critical for growing Australia’s Defence industry.Read moreRead less
Buffering the ecosystem impact of invasive cane toads. This project aims to address the devastating ecological problems caused by invasive species, by developing a novel approach that does not rely upon eradicating the invader through training vulnerable native predators not to eat toxic cane toads. Expected outcomes of this project include building a broad coalition of conservation-focused groups, from private land-owners and local businesses through to Indigenous groups and government and non- ....Buffering the ecosystem impact of invasive cane toads. This project aims to address the devastating ecological problems caused by invasive species, by developing a novel approach that does not rely upon eradicating the invader through training vulnerable native predators not to eat toxic cane toads. Expected outcomes of this project include building a broad coalition of conservation-focused groups, from private land-owners and local businesses through to Indigenous groups and government and non-government agencies across the entire Kimberley region. It will also result in the evaluation of methods for deployment of taste-aversion at a landscape scale. This should provide significant benefits by conserving vulnerable fauna and building a powerful network within a region of high biodiversity in tropical Australia.Read moreRead less
Evaluating Cancer Screening: Context, Evidence, Values And Ethics
Funder
National Health and Medical Research Council
Funding Amount
$572,460.00
Summary
The research and clinical communities are divided over whether certain forms of cancer screening do more harm than good. This project asks: What is the right thing to do about cancer screening now? Using robust qualitative methodologies, we will study real cases of cancer screening and analyse their ethical implications. Drawing on this data and analysis, we will produce tools to help policy-makers, consumers and professionals make good decisions about cancer screening in future.