Human RIPC-derived Regulatory Molecules For Cardioprotection Against Ischemic And Cardiopulmonary Bypass Injury
Funder
National Health and Medical Research Council
Funding Amount
$642,083.00
Summary
Our previous work indicates that evoked human blood borne factors confer protection against injury, due to loss of blood flow in heart muscle, when a brief stress is remotely applied to a limb (remote ischemic preconditioning). We have identified these proteins that appear to activate genetic and metabolic regulation of adaptive cell survival processes. We will now test their individual and combined capacity, efficiency and mechanisms of protection in the heart using cell and clinical models.
Towards Prevention Of Acute Kidney Injury After Cardiac Surgery
Funder
National Health and Medical Research Council
Funding Amount
$771,918.00
Summary
Open heart surgery saves thousands of lives each year in Australia, but often injures the kidney. Kidney oxygen deficiency is a major cause of kidney injury. We propose a new way to manage kidney oxygen levels during heart surgery, by measuring the level of oxygen in the urine in the bladder. We will determine whether low levels of oxygen in the urine during surgery predict later development of acute kidney injury, and whether patient management can be changed to optimize kidney oxygen levels.
Identifying A Plasma Borne Factor Of Remote Ischemic Preconditioning And Its Effect On The Plasma Proteome After Heart Surgery
Funder
National Health and Medical Research Council
Funding Amount
$82,094.00
Summary
During a heart operation, a patient needs a heart-lung bypass machine to supply blood to their body. We are interested in looking at a new therapy called Remote Ischaemic Preconditioning that may decrease the damaging effects of this heart-lung bypass machine. This therapy is applied using a blood pressure cuff before surgery and protects the organs. We want to see if this protects children who are having surgery for the first time and identify proteins in the blood that may be involved.
Identification Of A Plasma Factor Of Remote Ischemic Preconditioning And Its Effect On The Proteome After Heart Surgery
Funder
National Health and Medical Research Council
Funding Amount
$385,197.00
Summary
Heart surgery with the heart placed into arrest causes inflammation and tissue damage due to interrupted circulation. We know that prior brief interruption and restoration of blood supply called remote ischemic preconditioning (IPC) can protect heart and lungs against damage. Our previous studies indicate that IPC involves a circulating factor that protects the tissue by optimizing energy preservation. This knowledge can be applied to organ transplants, protection from stroke and heart attack.
The Role Of Coronary Artery Baroreceptors In Cardiopulmonary Reflexes
Funder
National Health and Medical Research Council
Funding Amount
$361,018.00
Summary
The blood vessels and heart contain sensors that report on the state of the circulation to the brain. Blood vessel sensors send information about the level of blood pressure to the brain, and the brain coordinates appropriate changes in the activity of the heart and blood vessels so that blood pressure stays within narrow limits and blood flow to the brain is protected. Heart sensors send information to the brain about pressures in the heart and the release of chemicals during heart pain. Specia ....The blood vessels and heart contain sensors that report on the state of the circulation to the brain. Blood vessel sensors send information about the level of blood pressure to the brain, and the brain coordinates appropriate changes in the activity of the heart and blood vessels so that blood pressure stays within narrow limits and blood flow to the brain is protected. Heart sensors send information to the brain about pressures in the heart and the release of chemicals during heart pain. Specialized pressure receptors, like the receptors on blood vessels, have recently been reported to exist on the main blood vessels in the heart and, although not extensively studied, likely send information to the brain to participate in blood pressure regulation and to protect the supply of blood to the heart. These heart receptors normally work in concert with, and overshadowed by, the blood vessel receptors. In cardiovascular disease this concerted and complimentary interaction may be lost, resulting in contradictory signals being sent to the brain and inappropriate regulatory responses occurring. To study the functions of these heart receptors we will compare the number and types of nerves going to the heart receptors with the nerves that go to the blood vessel receptors to tell us whether their functions are likely to be similar. We will activate the heart receptors in healthy conscious animals to see what happens to blood pressure, heart rate, breathing patterns and blood flow to different organs. Finally we will use brain mapping techniques to see which brain cells are excited when the heart receptors are excited, and brain cell recording techniques to determine how individual brain cells respond to heart or vessel information. These studies will provide important new information about heart sensors, and help us understand the role these sensors have in heart disease or heart attack. This knowledge will aid the development of effective new ways of treating heart disease.Read moreRead less