The Implementation And Evaluation Of Living Evidence In The Management Of Chronic Kidney Disease.
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Chronic kidney disease (CKD) is a growing health problem. Improving outcomes for patients with CKD requires the translation of research into clinical care. However, scientific research that underpins the management of CKD has rapidly increased, and traditional methods to summarise and inform clinical care are out of date. This project will develop, evaluate, and implement a new approach, known as ‘living-evidence’, that translates research evidence in real-time into the management of patients.
Understanding how an old heart gets stiff. Aging is accompanied by a stiffening of the heart and reduced function, which is accelerated by cardiovascular disease and leads to heart failure. How the heart stiffens is poorly understood. A new mechanism is proposed here, involving structural membrane proteins (termed caveolae and cavins) and a signalling molecule (nitric oxide). The current research aims to unravel the interplay between cardiac cells and these proteins/signals to cause stiffness an ....Understanding how an old heart gets stiff. Aging is accompanied by a stiffening of the heart and reduced function, which is accelerated by cardiovascular disease and leads to heart failure. How the heart stiffens is poorly understood. A new mechanism is proposed here, involving structural membrane proteins (termed caveolae and cavins) and a signalling molecule (nitric oxide). The current research aims to unravel the interplay between cardiac cells and these proteins/signals to cause stiffness and to determine whether this process governs normal aging of the heart. This work will advance understanding of how heart function is determined and reveal how the human heart changes with normal aging. Read moreRead less