Detection Of Cardiac Allograft Rejection By Peripheral Blood Gene Expression: A Novel Concept Of Personalized Approach To Transplantation.
Funder
National Health and Medical Research Council
Funding Amount
$292,705.00
Summary
Heart biopsy is required to detect rejection after heart transplantation. The cost of each biopsy is around $7,000 and at least 10 heart biopsies needed in the first post-transplant year alone. The biopsy is difficult for the patients and significant cost for the Australian healthcare system. Thus, it would be beneficial to identify rejection using a simple blood test. Such tool would help to reduce or eliminate the need for expensive heart biopsy and would reduce the cost by about 10 times.
Investigation Of Cardiac Stem Cell Regenerative Capabilities And Their Enhancement By Manipulation Of Telomerase Reverse Transcriptase
Funder
National Health and Medical Research Council
Funding Amount
$491,462.00
Summary
Heart failure rates are increasing exponentially in Australia and worldwide. One in two people diagnosed with severe heart failure will die within one year of diagnosis. This burden of heart failure is underpinned by the heart’s limited capacity for self-repair after injury. This limitation could be overcome by stimulating newly discovered stem cell populations residing within the adult heart itself. This project investigates ways to harness and enhance the power of these stem cells.
Sex Disparities In Management Of Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$624,203.00
Summary
We propose using linked routine Big Data from the NSW health system to investigate sex differences in medications prescribed following a first MI, including deviances from guideline recommendations. We will also quantify differences between women and men in subsequent adverse outcomes, such as recurrent MI, according to treatment prescribed, and will study variations in sex dif
Cardiovascular diseases and heart failure rates are increasing worldwide. This is largely a result of the heart’s limited capacity for self-repair. Stem cells now provide an exciting potential novel therapy. We have recently demonstrated the feasibility of this therapy in a preclinical model of heart attack. Nevertheless, further work is required before human clinical trials can take place. This project will dismantle barriers preventing progression to these clinical trials.
Defining The Cellular Basis For Therapeutic Angiogenesis: Characterisation Of Endothelial Progenitor Cell Populations
Funder
National Health and Medical Research Council
Funding Amount
$365,126.00
Summary
Endothelial progenitor cells (EPCs) have been thought to play a role in new blood vessel growth and repair of the heart & blood vessels. Owing to their potential regenerative capacity, there has been immense interest in EPCs as a means of facilitating new blood vessel growth for sufferers of cardiovascular disease. This study will comprehensively evaluate the role of EPCs in new blood vessel formation. It will have implications for potential use of EPCs to treat heart disease.
CCR4/NOT Complex Is A Conserved Regulator Of Heart Function
Funder
National Health and Medical Research Council
Funding Amount
$467,567.00
Summary
Cardiovascular diseases kill an Australian every 11 minutes. The goal of this proposal is to characterize the role of the conserved heart regulators in cardiac function and disease. Our combined multi-species and informatics approach has identified a major disease locus for sudden cardiac death in humans, which we propose to characterize. This work can lead to new classes of drugs to improve cardiac health and also aid in early diagnosis of patients susceptible to sudden cardiac death.