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Substrate Mapping And Ablation Of Ventricular Tachycardia
Funder
National Health and Medical Research Council
Funding Amount
$444,129.00
Summary
Sudden death is a tragic occurrence and can afflict Australians of all ages, racial and ethnic backgrounds. This research will aim to understand abnormalities in the heart muscle that cause dangerous heart rhythm abnormalities, which is the most common cause of sudden death. We will study ways to improve the technology of keyhole cardiac procedures so that it can be used to prevent these arrhythmias from occurring in the first place, and in improving the chance of long-term successful cure.
Type 2 diabetes is the most common endocrine disease in the world and up to 60% of diabetic patients have heart disease. Heart disease is the most expensive heath condition and biggest cause of death in Australia. Diabetic patients often accumulate fat (triglyceride) within their heart cells, leading to diabetic heart disease. The present study sought to determine if diabetic patients with increased fat within their heart cells have more scarring which eventually results heart muscle dysfunction ....Type 2 diabetes is the most common endocrine disease in the world and up to 60% of diabetic patients have heart disease. Heart disease is the most expensive heath condition and biggest cause of death in Australia. Diabetic patients often accumulate fat (triglyceride) within their heart cells, leading to diabetic heart disease. The present study sought to determine if diabetic patients with increased fat within their heart cells have more scarring which eventually results heart muscle dysfunction.Read moreRead less
Obstructive sleep apnea (OSA) is one of the most common complications of obesity and is independently associated with a reduced quality of life and cardiovascular disease. This project aims to identify the underlying factors linking obesity with OSA by examining how weight loss surgery can improve these factors. These important findings will contribute greatly to our understanding of OSA pathophysiology and are necessary to find better treatments for obesity-associated OSA.
Cardiac Dysfunction In Diabetes: A Novel Therapeutic Approach
Funder
National Health and Medical Research Council
Summary
Diabetes is a global epidemic with high mortality associated with heart failure. I propose a new hypothesis: diabetic heart failure reflects a progressive decline in heart pump efficiency due to an accumulation of large glycogen stores in heart muscle cells. This research aims to characterise the underlying causes of heart failure in diabetes and identify intervention potential to rescue function and prevent the progression into failure.
Development Of New Heart Failure Therapeutics By Analysing Signalling In Heart Failure As A Network
Funder
National Health and Medical Research Council
Funding Amount
$314,965.00
Summary
After detailed analysis of cell signalling in diseased heart tissue we will facilitate the discovery of new therapeutic drug targets to stop the progression of heart failure in its early stages. It is hoped that the detailed analysis of heart failure signalling as a network rather than as individual pathways will enable the discovery of drugs which are more successful in stopping the progression of heart failure than the currently available drugs.
Assessment Of Remote Ischemic Conditioning On Post-cardiac Arrest Myocardial Dysfunction By Magnetic Resonance Imaging, Invasive Coronary Hemodynamic Measurements And Markers Of Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$265,881.00
Summary
Cardiac arrest and heart attack continue to cause unacceptably high mortality and morbidity. Even following successful resuscitation many people do not recover due to the inflammation caused by a lack of blood flow. We will investigate remote ischemic conditioning, utilizing a combination of world class imaging with heart MRI, flow monitors directly in heart arteries and markers of inflammation, We aim to determine the impact and recovery to the heart, brain and circulation of this new therapy.
Assessing Efficacy Of Polyfunctional Nanoparticles Engineered For The Delivery Of Multiple Therapeutics In Reduction Of Cardiac Ischemia Reperfusion Injury
Funder
National Health and Medical Research Council
Funding Amount
$317,678.00
Summary
A reduction in heart muscle damage after a heart attack is associated with a reduction in heart failure and an increase in life expectancy. However to date many therapeutic agents are not successful at reducing muscle damage because of difficulty in delivering the drugs to the target site. This project will address these delivery issues by making use of multifunctional nanoparticles which will allow for targeted delivery and release of therapeutics directly to damaged tissue following injury.
Multidisciplinary Management Of Vertebral Metastases Identification Of Standardized Surgical Guidelines
Funder
National Health and Medical Research Council
Funding Amount
$358,604.00
Summary
The spine is the commonest site of cancer spread to the skeleton and often leads to severe pain and paralysis. Recent advances in surgical techniques enable removal and reconstruction of all tumours of the spine. However, surgery remains controversial because of the need to weigh up the patient’s estimated length of survival with the risks of surgery. Our aims are to develop clear guidelines on which patients to perform surgery on, and what type of surgery to perform.