The hidden secondary metabolite biosynthetic potential of fungi. This proposal aims to develop synthetic biology tools to allow rapid access to the hidden metabolites encoded in fungal genomes and discover how they interact with plant and animal hosts. Genome sequencing reveals that fungi harbour vast hidden potential for biosynthesis of bioactive small molecules. The lack of tools to efficiently access this hidden potential has hindered the ability to develop this uncharted chemical diversity f ....The hidden secondary metabolite biosynthetic potential of fungi. This proposal aims to develop synthetic biology tools to allow rapid access to the hidden metabolites encoded in fungal genomes and discover how they interact with plant and animal hosts. Genome sequencing reveals that fungi harbour vast hidden potential for biosynthesis of bioactive small molecules. The lack of tools to efficiently access this hidden potential has hindered the ability to develop this uncharted chemical diversity for pharmaceutics and agriculture, and understand their biological roles in pathogens. Expected outcomes include sources of bioactive molecules and better management of fungal diseases in crops and humans.Read moreRead less
Understanding the enigma of the most energetic particles in the Universe. By combining an innovative Unmanned Aerial Vehicle (UAV)-based calibration technique with the unparalleled sensitivity of future gamma-ray and radio telescope arrays, this project will study astronomical particle accelerators and Dark Matter with unprecedented accuracy. This will afford us a unique view of the Universe' most energetic processes and allow us to study the laws of physics inaccessible to us in the lab. In the ....Understanding the enigma of the most energetic particles in the Universe. By combining an innovative Unmanned Aerial Vehicle (UAV)-based calibration technique with the unparalleled sensitivity of future gamma-ray and radio telescope arrays, this project will study astronomical particle accelerators and Dark Matter with unprecedented accuracy. This will afford us a unique view of the Universe' most energetic processes and allow us to study the laws of physics inaccessible to us in the lab. In the context of interdisciplinary research, the UAV innovation created will also be leveraged against key applications of remote sensing. With these two goals, this project will demonstrate the capabilities of novel Australian technology whilst providing Australia with a unique science use-case in high-energy astrophysics.Read moreRead less