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Deciphering genome function in animal development. The normal development of an embryo depends on complex and finely tuned gene regulatory mechanisms. In this Fellowship, I will use sophisticated new technologies to discover which of our 30,000 genes is important for embryonic development, reveal the roles of these genes, and identify the control mechanisms that can go awry to cause birth defects. Our research will suggest new ways to diagnose and deal with these conditions, and will be applicab ....Deciphering genome function in animal development. The normal development of an embryo depends on complex and finely tuned gene regulatory mechanisms. In this Fellowship, I will use sophisticated new technologies to discover which of our 30,000 genes is important for embryonic development, reveal the roles of these genes, and identify the control mechanisms that can go awry to cause birth defects. Our research will suggest new ways to diagnose and deal with these conditions, and will be applicable to stem cell technologies, tissue regeneration, cancer biology, conservation, pest management and livestock breeding, thus delivering significant economic and social benefits to Australia. Read moreRead less
How organisms coordinate energy supply and demand. The metabolic stress sensing protein kinase called the AMP activated protein kinase controls metabolism of all eukaryotes to meet the needs of energy demand and nutrient supply. It is responsible for accelerating metabolism (glucose transport, glycolysis and fatty acid oxidation) in response to energy demand and with caloric restriction it regulates gene transcription to adapt to energy supply. This project is to provide a comprehensive unders ....How organisms coordinate energy supply and demand. The metabolic stress sensing protein kinase called the AMP activated protein kinase controls metabolism of all eukaryotes to meet the needs of energy demand and nutrient supply. It is responsible for accelerating metabolism (glucose transport, glycolysis and fatty acid oxidation) in response to energy demand and with caloric restriction it regulates gene transcription to adapt to energy supply. This project is to provide a comprehensive understanding of the AMP activated protein kinase (enzyme isoforms, genes, physiological roles and regulation). This knowledge will have major benefits in biopharmaceutical development, the livestock, plant and sport/racing industries.Read moreRead less
Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific commun ....Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific community and will be disseminated back to the scientific community, to the humanities and to the Australian public. The project will bring to Australia the strengths of the applicant's existing collaborations with leading research centres in this field in the USA, UK and Canada.Read moreRead less
Role of an ancient genetic program in the elaboration of plant architecture. This proposal will reveal how plant architecture is controlled by genes. Ultimately it will help us manipulate plant form tailored for Australia's crops, pastures and plantations. Potential benefits include larger leaves, more fruits and seeds, and timbers with new properties. As a young researcher I bring a strong and growing international reputation in plant molecular developmental genetics with world-wide collaborati ....Role of an ancient genetic program in the elaboration of plant architecture. This proposal will reveal how plant architecture is controlled by genes. Ultimately it will help us manipulate plant form tailored for Australia's crops, pastures and plantations. Potential benefits include larger leaves, more fruits and seeds, and timbers with new properties. As a young researcher I bring a strong and growing international reputation in plant molecular developmental genetics with world-wide collaborations to build a focus of excellence in Australian plant development research.
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The toxins of water-borne cyanobacteria: regulation and exploitation of their biosynthesis. Water quality is a major concern in Australia, as is the global need for new natural products with antibiotic activity. The mechanisms by which cyanobacteria produce toxins that reduce the quality of water may very well be the answer to the lack of novel medicinal compounds currently being discovered in nature. Encompassed in this one program are the aims of ameliorating the effects of toxic algal blooms ....The toxins of water-borne cyanobacteria: regulation and exploitation of their biosynthesis. Water quality is a major concern in Australia, as is the global need for new natural products with antibiotic activity. The mechanisms by which cyanobacteria produce toxins that reduce the quality of water may very well be the answer to the lack of novel medicinal compounds currently being discovered in nature. Encompassed in this one program are the aims of ameliorating the effects of toxic algal blooms as well as introducing the means for the design and synthesis of a range of novel bioactive products. The benefits include better water quality and biosafety management options, a new generation of drug design and discovery, and the associated transformation of environmental and medical research and education in Australia.Read moreRead less
Discovering genes and mechanisms regulating immune responses. The Fellowship will retain and expand a pioneering Australian research program, and attract to Australia major international investment and technology linkages, making use of the DNA sequence of humans and other mammals to advance understanding of immunity and infection control in public health, agriculture and industry. The program will build on Australia's pre-eminent research strengths in the field of immunity and infection, and w ....Discovering genes and mechanisms regulating immune responses. The Fellowship will retain and expand a pioneering Australian research program, and attract to Australia major international investment and technology linkages, making use of the DNA sequence of humans and other mammals to advance understanding of immunity and infection control in public health, agriculture and industry. The program will build on Australia's pre-eminent research strengths in the field of immunity and infection, and will create new knowledge and resources to improve human and animal health through vaccines, pharmaceuticals and public health policy. Read moreRead less
Salinity tolerance and long-distance transport in cereals. The aim of this program is to alter shoot accumulation of solutes in cereals by exploiting novel transgenic technology to manipulate processes in specific cell types in the roots. The primary objective is the generation of cereals which have increased tolerance of saline soils. This is clearly of much agricultural significance in Australia. More general outcomes include the generation of plants with altered concentrations of a range of n ....Salinity tolerance and long-distance transport in cereals. The aim of this program is to alter shoot accumulation of solutes in cereals by exploiting novel transgenic technology to manipulate processes in specific cell types in the roots. The primary objective is the generation of cereals which have increased tolerance of saline soils. This is clearly of much agricultural significance in Australia. More general outcomes include the generation of plants with altered concentrations of a range of nutrients in both leaves and grain. This will be of wide agricultural and nutritional benefit, as well as providing an understanding of principles underlying the long-distance co-ordination of processes in plants.Read moreRead less
Self, the social body and wellbeing: Embodiment and adaptation in cross-cultural perspective. This interdisciplinary programme will contribute to understanding how ideas of the self, social relationships and their meanings, are revised and restructured as a result of embodied change. Ethonographic research will be conducted with Australian men and women who have had serious chronic illness and surgery, including stroke and kidney disease. Comparative research will be conducted in Thailand, the C ....Self, the social body and wellbeing: Embodiment and adaptation in cross-cultural perspective. This interdisciplinary programme will contribute to understanding how ideas of the self, social relationships and their meanings, are revised and restructured as a result of embodied change. Ethonographic research will be conducted with Australian men and women who have had serious chronic illness and surgery, including stroke and kidney disease. Comparative research will be conducted in Thailand, the Cameroon and Haiti throughcollaborations developed during the Fellowship. The work will contribute to international debates about wellbeing, social capital and resilience in different cultural, social and economic settings.Policy implications relate to community connectedness, health and welfare services, and infrastructure.Read moreRead less
The New Paradigm of International Migration to and from Australia: Dimensions, Causes and Implications. Population movement to and from Australia is undergoing a major transformation but much thinking about immigration in Australia remains based on paradigms of the past. Yet debates such as those on immigration's contribution to national population size and growth, the significance of skilled migration, the response to asylum seekers, undocumented movement and the role of temporary versus settle ....The New Paradigm of International Migration to and from Australia: Dimensions, Causes and Implications. Population movement to and from Australia is undergoing a major transformation but much thinking about immigration in Australia remains based on paradigms of the past. Yet debates such as those on immigration's contribution to national population size and growth, the significance of skilled migration, the response to asylum seekers, undocumented movement and the role of temporary versus settlement migration have increased. This study identifies emerging trends of migration, examines global and domestic drivers of the movement in the context of developing migration theory, explores the economic, social and demographic consequences and draws out the implications for immigration and population policy.Read moreRead less
Small RNAs: what makes a plant, a plant. Understanding the roles of small RNAs and their pathways is a young field of research that is giving, and will continue to give, profound insights into how multicellular organisms regulate gene expression at a genomic level. Research in this area has already led to RNA interference technology, by which almost any gene can be switched off, and there is considerable potential for other gene silencing and trait modification technologies to emerge. The projec ....Small RNAs: what makes a plant, a plant. Understanding the roles of small RNAs and their pathways is a young field of research that is giving, and will continue to give, profound insights into how multicellular organisms regulate gene expression at a genomic level. Research in this area has already led to RNA interference technology, by which almost any gene can be switched off, and there is considerable potential for other gene silencing and trait modification technologies to emerge. The project will yield insights into fundamental biological processes which are expected to engender applications in agriculture and biotechnology. It will maintain and enhance Australia's position in this area.Read moreRead less