Protracted Bacterial Bronchitis(PBB) In Children - Natural History, Innate Immunity And Obstructive Sleep Disorders
Funder
National Health and Medical Research Council
Funding Amount
$97,438.00
Summary
Recurrent episodes of prolonged wet cough in children, termed Protracted Bacterial Bronchitis (PBB), may cause long term lung damage. I am a paediatric respiratory and sleep subspecialist in training. Through our research we will investigate for abnormalities in the immune system of children with recurring episodes of PBB and follow these children over a 2 year period to determine whether they go on to develop lung scarring. We will also be looking for a link between PBB and obstructive sleep pr ....Recurrent episodes of prolonged wet cough in children, termed Protracted Bacterial Bronchitis (PBB), may cause long term lung damage. I am a paediatric respiratory and sleep subspecialist in training. Through our research we will investigate for abnormalities in the immune system of children with recurring episodes of PBB and follow these children over a 2 year period to determine whether they go on to develop lung scarring. We will also be looking for a link between PBB and obstructive sleep problems in children.Read moreRead less
Protracted Bacterial Bronchitis: Long Term Outcomes, Systemic And Airway Predictors Of Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$804,405.00
Summary
Our study will determine the long term clinical outcomes of children with protracted bacterial bronchitis (PBB), a common cause of chronic cough in children. We will also conduct novel experiments that were pioneered in Australia to evaluate recurrent PBB.
Chronic obstructive pulmonary disease (COPD) is a smoking-induced lung disease that is the fourth leading cause of death in Australia. The immune system is highly likely to play an important role in the progression of this condition, because of the frequency of respiratory infections that occur. We will examine in detail the immune response of COPD patients, examining specific genes and proteins that are important in the defence against bacteria. Blood samples will be obtained from people with C ....Chronic obstructive pulmonary disease (COPD) is a smoking-induced lung disease that is the fourth leading cause of death in Australia. The immune system is highly likely to play an important role in the progression of this condition, because of the frequency of respiratory infections that occur. We will examine in detail the immune response of COPD patients, examining specific genes and proteins that are important in the defence against bacteria. Blood samples will be obtained from people with COPD who are stable. We will then obtain further blood samples when there is a flare-up of the lung condition, and during recovery. We will compare the results from the blood samples, with variations in the genes that people carry. Information about individual differences in the body's response to infection would help us to better understand how COPD develops, and to initiate research on new methods of diagnosis and treatment of COPD.Read moreRead less