A New Direction For TB Control In Highly Endemic Countries: A RCT Of Active Case Finding
Funder
National Health and Medical Research Council
Funding Amount
$1,362,910.00
Summary
Tuberculosis is the number 1 health problem in Vietnam . Many people with TB do not know they have the disease but are infectious to others. Hence, the disease continues to spread. This project will investigate the role of x-ray screening to detect and treat more people with TB, particularly those who do not have symptoms. This may be an important element of future TB control programs in Vietnam and elsewhere in our region.
A Randomized Clinical Trial Comparing Effectiveness Of 4RIF And 9INH For Treatment Of Latent TB Infection
Funder
National Health and Medical Research Council
Funding Amount
$496,875.00
Summary
Treatment of latent tuberculosis infection (LTBI) is one intervention that is known to prevent the occurrence of active TB. Current treatment is based on a six to nine month course of isoniazid. The treatment has side effects in some people and many people do not complete the treatment. The present study is to test an alternative treatment regimen (4 months of rifampicin) which has fewer side-effects and is more likely to be completed.
Marker assisted selection of honey bees. The project will develop new molecular markers for commercially relevant trait of honey bees and ways of using these to implement marker-assisted selection for honey bee genetic improvement. Beekeepers need to use genetically improved stock to remain competitive. Honey production needs to be improved, and new ways of identifying disease resistant bees are needed. Unfortunately, breeding bees is very difficult. This project will use modern molecular gen ....Marker assisted selection of honey bees. The project will develop new molecular markers for commercially relevant trait of honey bees and ways of using these to implement marker-assisted selection for honey bee genetic improvement. Beekeepers need to use genetically improved stock to remain competitive. Honey production needs to be improved, and new ways of identifying disease resistant bees are needed. Unfortunately, breeding bees is very difficult. This project will use modern molecular genetic techniques to help find new efficient ways to breed better bees. The benefits will be a more viable beekeeping sector, a keystone industry that provides pollination services essential to many horticultural industriesRead moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130200013
Funder
Australian Research Council
Funding Amount
$4,979,922.00
Summary
ARC Research Hub for advanced breeding to transform prawn aquaculture. ARC Research Hub for advanced breeding to transform prawn aquaculture. This Research Hub aims to bring together world-leading animal geneticists, research and service providers, and Australia's largest prawn farm to gather the genomic resources, commercial phenotypic data, and apply cutting-edge genetic and genomic selection methodologies, leading to the transformative improvement program for a black tiger prawn aquaculture s ....ARC Research Hub for advanced breeding to transform prawn aquaculture. ARC Research Hub for advanced breeding to transform prawn aquaculture. This Research Hub aims to bring together world-leading animal geneticists, research and service providers, and Australia's largest prawn farm to gather the genomic resources, commercial phenotypic data, and apply cutting-edge genetic and genomic selection methodologies, leading to the transformative improvement program for a black tiger prawn aquaculture species globally.Read moreRead less
Understanding, controlling and improving the flavour of almond kernels. Almond kernels may be sweet, semi-bitter or bitter, with the first two categories marketed as fresh nuts, while the latter are used in processed products such as marzipan. Semi-bitter kernels have a more interesting flavour than sweet kernels and we require tools to breed for this character. The bitter flavour is imparted by amygdalin via the cyanogenic pathway. This project will characterise the genetic control of sweet, ....Understanding, controlling and improving the flavour of almond kernels. Almond kernels may be sweet, semi-bitter or bitter, with the first two categories marketed as fresh nuts, while the latter are used in processed products such as marzipan. Semi-bitter kernels have a more interesting flavour than sweet kernels and we require tools to breed for this character. The bitter flavour is imparted by amygdalin via the cyanogenic pathway. This project will characterise the genetic control of sweet, semi-bitter and bitter flavour, amygdalin accumulation in developing kernels, and key enzymes in the cyanogenic pathway. Almond populations segregating for these traits will be used and the data will be integrated into the Australian almond meiotic map.Read moreRead less
Investigation of almond transformation for self-fertility and virus resistance. This project addresses the long-term goal of the Australian almond industry to produce cultivars that are self-fertile and resistant to Prunus necrotic ringspot and prune dwarf viruses. Both self-sterility and virus infection can result in unreliable and often low yields. Research will address the control of gene expression relating to self-sterility and the introduction of virus resistance, via sequencing of self- ....Investigation of almond transformation for self-fertility and virus resistance. This project addresses the long-term goal of the Australian almond industry to produce cultivars that are self-fertile and resistant to Prunus necrotic ringspot and prune dwarf viruses. Both self-sterility and virus infection can result in unreliable and often low yields. Research will address the control of gene expression relating to self-sterility and the introduction of virus resistance, via sequencing of self-fertility and self-sterility genes, construct development and improved regeneration of transformed almond in vitro without the use of antibiotics.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100016
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Predictive Breeding for Agricultural Futures. This Centre aims to develop the advanced capacity needed to secure Australia’s food and fibre production and export value into the future. Leveraging immense industry support, the Centre expects to develop and integrate cutting-edge plant and animal breeding technologies and deliver world-class training that addresses critical demand for highly skilled industry leaders. Expected outcomes include a future-ready predictive breedi ....ARC Training Centre in Predictive Breeding for Agricultural Futures. This Centre aims to develop the advanced capacity needed to secure Australia’s food and fibre production and export value into the future. Leveraging immense industry support, the Centre expects to develop and integrate cutting-edge plant and animal breeding technologies and deliver world-class training that addresses critical demand for highly skilled industry leaders. Expected outcomes include a future-ready predictive breeding industry able to transform data into optimised decisions, and the human capacity to drive it. This should provide significant benefits to enhance the sustainability and profitability of all major Australian agriculture sectors, including livestock, grains, horticulture, cotton, wine, dairy, forestry and fisheries.Read moreRead less
Reducing environmental footprint by improving phosphorous use efficiency. While modern agriculture relies heavily on the use of phosphorous fertilizers, most of them are not used by plants and lost in runoff, resulting in a massive environmental damage through contamination of waterways (termed eutrophication). This project takes advantage of an untapped resource - a unique collection of Tibetan wild barley genotypes, to reveal key traits that confer superior phosphorus use efficiency in wild ba ....Reducing environmental footprint by improving phosphorous use efficiency. While modern agriculture relies heavily on the use of phosphorous fertilizers, most of them are not used by plants and lost in runoff, resulting in a massive environmental damage through contamination of waterways (termed eutrophication). This project takes advantage of an untapped resource - a unique collection of Tibetan wild barley genotypes, to reveal key traits that confer superior phosphorus use efficiency in wild barley and identify appropriate candidate genes and their position on chromosomes for further incorporating these traits into commercial barley cultivars. This will reduce the environmental footprint of modern agricultural practices on terrestrial and aquatic ecosystems without compromising food security.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100168
Funder
Australian Research Council
Funding Amount
$413,847.00
Summary
Self-Supervised Sequential Biomedical Image-Omics. This project aims to develop a self-supervised sequential biomedical image-omics model to uncover the underlying biological processes e.g., normal or abnormal. Sequential biomedical images are state-of-the-art imaging modalities which allow to depict changes in progression to the human body. New self-supervised machine learning algorithms are proposed to derive features from heterogenous and unlabelled sequential images. These derived features w ....Self-Supervised Sequential Biomedical Image-Omics. This project aims to develop a self-supervised sequential biomedical image-omics model to uncover the underlying biological processes e.g., normal or abnormal. Sequential biomedical images are state-of-the-art imaging modalities which allow to depict changes in progression to the human body. New self-supervised machine learning algorithms are proposed to derive features from heterogenous and unlabelled sequential images. These derived features will then be used to characterise the morphological and functional changes, which provide opportunities to increase understanding of progression of diseases of individual subject. The outcome from this project will provide new insights into system biology with potential future benefits in healthcare.Read moreRead less
A formal foundation for security architecture. Security of computer systems is essential for the maintenance of privacy, confidentiality and integrity of personal, commercial and government data, and the trustworthiness of the computational devices that are embedded in critical societal infrastructure. However, current theoretical understanding of secure systems development is poor. The project will develop our understanding of an emerging approach to the design of secure systems and develop ver ....A formal foundation for security architecture. Security of computer systems is essential for the maintenance of privacy, confidentiality and integrity of personal, commercial and government data, and the trustworthiness of the computational devices that are embedded in critical societal infrastructure. However, current theoretical understanding of secure systems development is poor. The project will develop our understanding of an emerging approach to the design of secure systems and develop verification methods that may be applied to guarantee systems security. Its outcomes will contribute to processes for certifying systems at very high levels of security, a requirement in defence and government settings that will become increasingly significant in the commercial sector.Read moreRead less