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Unified platform for real time QA in radiation therapy in brachytherapy based on high resolution silicon detectors (Magic Plate). This project will design and manufacture new devices for measuring the amount of radiation given to the patient during radiotherapy. This will improve the accuracy and safety of cancer treatment as well as greatly reducing the time needed to perform essential safety checks.
Image-guided skin microbiopsy technology development. There is a need for targeted biopsies in dermatology. This novel technology enables minimally invasive biopsies to be taken from suspicious skin lesions by integrating micromedical and imaging devices.
Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commerci ....Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commercial potential and important societal benefits.Read moreRead less
High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells a ....High-resolution elastography – Using optical micro-imaging of tissue mechanics to identify disease. Optical elastography, the probing of tissue’s micro-mechanical properties using optical imaging, offers new tools in surgery and pathology to improve differentiation of tissues. This project lays the groundwork for optical elastography to become a new medical micro-imaging modality by removing impediments to progress in this rapidly emerging field. On the micro-scale, between the scales of cells and organs. This project will elucidate the origins of tissue mechanical contrast and determine limits on its measurement. It will develop a suite of probes: noncontact, endoscopic and needle, to enable access to all tissues in the body. To progress toward a new modality and inform our research, the project will test our tools on breast cancer tissues and burn scars.Read moreRead less
Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
Three dimensional (3D) optical coherence tomography in cancer. This project will establish for the first time how well 3D optical coherence tomography, a form of medical imaging, can image cancer. Based on this, a version built into a needle will be developed which will enable extension much deeper into tissues than previously possible to image cancer and to guide related surgical procedures.