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The Molecular Basis For Target Selection In The Central Nervous System By Sensory Axons
Funder
National Health and Medical Research Council
Funding Amount
$251,325.00
Summary
The normal function of the brain depends upon the specific connections that nerve cells make with each other. These connections are set up in the developing embryo when nerve cells send out long processes - axons - which grow towards their synaptic targets. How axons select their correct targets from amongst the millions of alternatives in the developing brain is unknown. A better understanding of this problem will help us develop therapies to assist regenerating axons re-establish correct conne ....The normal function of the brain depends upon the specific connections that nerve cells make with each other. These connections are set up in the developing embryo when nerve cells send out long processes - axons - which grow towards their synaptic targets. How axons select their correct targets from amongst the millions of alternatives in the developing brain is unknown. A better understanding of this problem will help us develop therapies to assist regenerating axons re-establish correct connections following injury to the brain or spinal cord. We propose to use a simple model system, the embryo of the fruitfly Drosophila, to find molecules that are involved in this process of neuron target recognition - ' axon targeting' molecules - and to study how they work. Drosophila can be genetically manipulated in ways not possible in higher animals. Furthermore the simplicity of its nervous system means that we can determine the connections of individual nerve cells with a high degree of precision. In the first part of our project, we will examine Drosophila embryos that carry mutations in genes suspected to code for targeting molecules. We will stain individual sensory nerve cells in these embryos with dyes to reveal the anatomy of their axons in the brain. If sensory axons terminate abnormally in the brain of a given mutant, the affected gene is likely to code for an axon targeting molecule. In the second part of the study, we will investigate the functions of candidate axon targeting molecules using two approaches. Firstly, we will seek to determine whether the molecule acts in the sensory axons or in their target cells. Secondly, we will use time-lapse microscopy to study how the homing behaviour of the sensory axons is affected in mutant embryos. The results of these studies will lead us closer to an answer to the question: How do axons recognise their specific target cells in the brain?Read moreRead less
Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease le ....Genomic and molecular characterisation of a novel Australian leishmania pathogen. Leishmaniasis is the second most serious protozoal disease after malaria. This project will help characterise the first Leishmania species identified in Australia providing molecular tools to monitor the pathogen and a detailed assessment of any potential risk to human health. Comparative analysis with more pathogenic species will help identify genes and mechanisms that determine the progression of human disease leading to the potential identification of new drug and vaccine targets. The methodologies and expertise developed will be used will be available to other research groups working on infectious diseases.Read moreRead less
A stochastic geometric framework for Bayesian sensor array processing. This project develops a mathematical framework, and a new generation of techniques, for sensor array processing to address real-world problems with uncertainty in array parameters and number of signals. The outcomes will enhance the capability of sensors in many application areas including, radar, sonar, astronomy and wireless communications.
Modelling and estimation methods for discrete multi-dimensional systems. Multi-dimensional signal processing plays a role in a variety of application areas, ranging from remote sensing for environmental monitoring and geological mapping, to medical imaging and the automatic control of industrial processes. The success of the project will provide mathematical tools for the advancement of the state-of-the-art in these broad areas.
INTEGRATED PASSIVE AND ACTIVE CONTROL OF HUMMING NOISE FROM KCGM’S HAUL TRUCKS. This project aims to resolve an environmental noise issue caused by the humming noise of Kalgoorlie Consolidated Gold Mines haul trucks in the areas of Kalgoorlie, Boulder, and Williamstown. This solution utilises integrated passive and active control systems to attenuate the frequency components of humming noise from a truck’s exhaust and engine. A novel aspect of this technique is the use of passive micro-perforate ....INTEGRATED PASSIVE AND ACTIVE CONTROL OF HUMMING NOISE FROM KCGM’S HAUL TRUCKS. This project aims to resolve an environmental noise issue caused by the humming noise of Kalgoorlie Consolidated Gold Mines haul trucks in the areas of Kalgoorlie, Boulder, and Williamstown. This solution utilises integrated passive and active control systems to attenuate the frequency components of humming noise from a truck’s exhaust and engine. A novel aspect of this technique is the use of passive micro-perforated structures to provide the necessary sound absorption capability and to alter the sound propagation and radiation properties of the truck exhaust and engine, and increase the effectiveness of active control.Read moreRead less
A direct drive linear tube generator for ocean wave energy conversion. This project aims to investigate a direct drive linear electromagnetic generator system for the maximum wave energy conversion and frequency bandwidth. This system has a translator of a multiple degree of freedom non-linear oscillator system built with the Halbach ring array pattern and ferro-fluid bearings. To establish wave energy conversion science, this project will investigate the device, its integration with a buoy stru ....A direct drive linear tube generator for ocean wave energy conversion. This project aims to investigate a direct drive linear electromagnetic generator system for the maximum wave energy conversion and frequency bandwidth. This system has a translator of a multiple degree of freedom non-linear oscillator system built with the Halbach ring array pattern and ferro-fluid bearings. To establish wave energy conversion science, this project will investigate the device, its integration with a buoy structure under wave loadings and automatic control of power conversion and conditioning. The outcome could meet demands for wave energy conversion technologies that reduce power generation cost and emissions, benefiting the Australian economy and environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100957
Funder
Australian Research Council
Funding Amount
$339,328.00
Summary
Partial differential equations, free boundaries and applications. This project aims to investigate fundamental problems in the analysis of partial differential equations and free boundary theory, to develop advanced mathematical theories with the possibility of important applications. The expected outcome is the establishment of a regularity and classification theory for nonlocal equations and for free boundary problems in linear and nonlinear settings. The benefit of the project lies in a concr ....Partial differential equations, free boundaries and applications. This project aims to investigate fundamental problems in the analysis of partial differential equations and free boundary theory, to develop advanced mathematical theories with the possibility of important applications. The expected outcome is the establishment of a regularity and classification theory for nonlocal equations and for free boundary problems in linear and nonlinear settings. The benefit of the project lies in a concrete advancement of the mathematical research with advantages for a deeper understanding of complex phenomena in physics and biology. Some of the problems also provide results useful for industrial applications.Read moreRead less
Performance evaluation and characterisation for filtering in multi-object system. The project falls within the National Research Priority of 'Safeguarding Australia' and associated research priority goal of 'Transforming Defence Technology'. The project outcomes will provide cutting edge technology in surveillance, and monitoring of potential threat in our air, sea, and land space. Fast, reliable information enable our personnel to make timely, intelligent judgements, and appropriate responses i ....Performance evaluation and characterisation for filtering in multi-object system. The project falls within the National Research Priority of 'Safeguarding Australia' and associated research priority goal of 'Transforming Defence Technology'. The project outcomes will provide cutting edge technology in surveillance, and monitoring of potential threat in our air, sea, and land space. Fast, reliable information enable our personnel to make timely, intelligent judgements, and appropriate responses in the event of a threat, thereby maintaining Australia's operational advantage. Other application areas that benefits from our research include radar, sonar, guidance, navigation, air traffic control, image processing, oceanography, autonomous vehicles and robotics, remote sensing, and biomedical research.
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Optimal Control of Multi-Object System. Better understanding of multi-object systems developed from this research, in particular, optimal control algorithms for multi-object systems have several significant socio-economic benefits. Application areas that benefits from our research include aerospace applications such as radar, sonar, guidance, navigation, and air traffic control and non-aerospace areas such as image processing, oceanography autonomous vehicles and robotics, remote sensing, and bi ....Optimal Control of Multi-Object System. Better understanding of multi-object systems developed from this research, in particular, optimal control algorithms for multi-object systems have several significant socio-economic benefits. Application areas that benefits from our research include aerospace applications such as radar, sonar, guidance, navigation, and air traffic control and non-aerospace areas such as image processing, oceanography autonomous vehicles and robotics, remote sensing, and biomedical research. The sensor network discipline also stand to benefit from the understanding of multi-object system and control framework. Read moreRead less