Developing A Prototype Of A Next Generation Brain Computer Interface
Funder
National Health and Medical Research Council
Funding Amount
$837,398.00
Summary
Persons affected by quadriplegia and hemiplegia from stroke and spinal cord injury have few treatment options. Brain Machine Interfaces reconnect brain to a prosthetic limb, bypassing damaged nervous system. Our group has developed a BMI that can be implanted minimally-invasively, inside a blood vessel in the brain. We propose to manufacture a world-first device for a human clinical trial pilot study. The aim is to restore mechanical control over the physical environment for a paralysed patient.
Evaluation Of A Tailored Online Hospital And Post-discharge Smoking Cessation Program For Orthopaedic Trauma Surgery Patients
Funder
National Health and Medical Research Council
Funding Amount
$370,818.00
Summary
Smoking causes serious post-surgery complications and may lengthen recovery time. Hospitalisation is an ideal opportunity to encourage quitting to patients who smoke. We have found high rates of smoking among trauma surgery patients, and high interest to quit, yet few reported receiving advice to quit. We have designed an online quit support program for patients. The program is expected to help patients to quit smoking, leading to improvements in their recovery and general health.
Soil microbial indicators for efficient use of nitrification inhibitors. Soil microbial indicators for efficient use of nitrification inhibitors. This project aims to improve understanding of the efficiency and governing factors of nitrification inhibitors in different agricultural soils. Nitrification inhibitors are widely used to improve nitrogen fertiliser efficiency and reduce greenhouse gas nitrous oxide emissions. However, their effectiveness varies across soil types. One possible reason i ....Soil microbial indicators for efficient use of nitrification inhibitors. Soil microbial indicators for efficient use of nitrification inhibitors. This project aims to improve understanding of the efficiency and governing factors of nitrification inhibitors in different agricultural soils. Nitrification inhibitors are widely used to improve nitrogen fertiliser efficiency and reduce greenhouse gas nitrous oxide emissions. However, their effectiveness varies across soil types. One possible reason is the different microbial communities in these soils. The project will address the key knowledge gaps of interactions between the nitrification inhibitors and the soil functional microbial communities. Anticipated outcomes are sound management strategies to improve fertiliser nitrogen use efficiency in Australian agricultural soils.Read moreRead less
Quantifying The Role Of Epigenetic Factors In Neurocognitive Outcomes: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$1,516,790.00
Summary
We aim to identify the environmental factors in early life that contribute towards an individual brain development using MRI brain scans and related psychological skills measured in late childhood. We are using twins to better understand differences in their early life environments independent of genetics.
Unraveling the spread of antibiotic resistance genes across soil food webs. The emerging spread of antibiotic resistance genes (ARGs) in the environment is a major threat to public health and food security. This project aims to develop new knowledge about the key transmission routes of ARGs across multiple trophic levels in soil food webs, and how the interactions of plant, soil and fauna contribute to the profiles of environmental ARGs. Expected outcomes include an improved understanding of the ....Unraveling the spread of antibiotic resistance genes across soil food webs. The emerging spread of antibiotic resistance genes (ARGs) in the environment is a major threat to public health and food security. This project aims to develop new knowledge about the key transmission routes of ARGs across multiple trophic levels in soil food webs, and how the interactions of plant, soil and fauna contribute to the profiles of environmental ARGs. Expected outcomes include an improved understanding of the role of fauna in regulating ARGs in the soil environment and the spreading mechanisms of antibiotic resistance in soil food webs. This project will contribute to the development of evidence-based interventions to tackle environmental antibiotic resistance, which has benefits for the environment and public health.
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Industry Laureate Fellowships - Grant ID: IL230100154
Funder
Australian Research Council
Funding Amount
$2,582,419.00
Summary
Fixing the NDIS: cost, effectiveness and access for psychosocial disability. This project aims to address serious deficits in the operation of the National Disability Insurance Scheme for one of its largest participant groups: people with psychosocial disability. This project expects to develop new data on scheme outcomes, cost-effectiveness and participant experiences to develop an appropriate and implementable program logic to improve supports for this group. Expected outcomes will be scheme r ....Fixing the NDIS: cost, effectiveness and access for psychosocial disability. This project aims to address serious deficits in the operation of the National Disability Insurance Scheme for one of its largest participant groups: people with psychosocial disability. This project expects to develop new data on scheme outcomes, cost-effectiveness and participant experiences to develop an appropriate and implementable program logic to improve supports for this group. Expected outcomes will be scheme reform by implementing a new framework of supports for psychosocial disability and data to improve the operation of national policy for this group more broadly. This should provide significant benefits for the cost-effective operation of the National Disability Insurance Scheme and build research capacity in disability policy.Read moreRead less
ASPREE is the largest clinical trial ever conducted in Australia and will determine whether daily low dose aspirin prevents disease in healthy older people. The study was well-funded initially but will require additional support to complete the vital final stage of data collection and analysis. This will enable the study to answer important questions about the benefits and risks of aspirin in this age group and its effect on disability free survival.
Contribution of comammox bacteria to soil nitrification. This project aims to understand the diversity, activity and environmental relevance of comammox bacteria, the newly-discovered complete nitrifiers, in Australian soils, and to evaluate their relative contributions to nitrification processes compared to other canonical nitrifying prokaryotes. Nitrogen transformations are pivotal microbial processes, with nitrification largely responsible for nitrogen losses through nitrous oxide emissions a ....Contribution of comammox bacteria to soil nitrification. This project aims to understand the diversity, activity and environmental relevance of comammox bacteria, the newly-discovered complete nitrifiers, in Australian soils, and to evaluate their relative contributions to nitrification processes compared to other canonical nitrifying prokaryotes. Nitrogen transformations are pivotal microbial processes, with nitrification largely responsible for nitrogen losses through nitrous oxide emissions and nitrate leaching in the terrestrial ecosystems. The expected outcomes will develop new knowledge on the comammox bacteria and provide novel insights into refined strategies to manipulate nitrification processes for improved nitrogen use efficiency and sustainable agricultural management.Read moreRead less
Targeting Tau Phosphorylation To Treat And Prevent Acquired Epilepsy, Neurodegeneration And Neuropsychiatric Disease Following A Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$524,820.00
Summary
This project will explore a new approach to the prevention and treatment of epilepsy and the associated mental health disorders following a brain injury. This involves inhibiting pathological forms of the Tau protein, which has been implicated in the development of epilepsy and neurodegeneration. The drug that will be tested in this study has already been demonstrated to be safe and well tolerated in humans, meaning that a positive result from these studies could be expediently translated into c ....This project will explore a new approach to the prevention and treatment of epilepsy and the associated mental health disorders following a brain injury. This involves inhibiting pathological forms of the Tau protein, which has been implicated in the development of epilepsy and neurodegeneration. The drug that will be tested in this study has already been demonstrated to be safe and well tolerated in humans, meaning that a positive result from these studies could be expediently translated into clinical studies.Read moreRead less
A Multi-cohort Investigation Of The Effects Of BDNF Val66Met On Tau, Neurodegeneration And Cognition In Preclinical Alzheimer’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$325,758.00
Summary
There are currently no disease modifying therapies for Alzheimer’s disease. We will elucidate the role of a genetic polymorphism that has previously been shown to exert neuroprotective effects on memory decline and brain volume loss associated with Alzheimer’s disease. By studying the role of this gene in multiple cohorts of individuals with varying degrees of Alzheimer’s disease risk, this study has high potential to uncover novel disease-modifying strategies for the treatment of the disease.