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Understanding Predictors Of Fatigue After Brain Injury In Children.
Funder
National Health and Medical Research Council
Funding Amount
$98,459.00
Summary
This research will examine what factors predict the fatigue children will experience after brain injury. This study is important because fatigue is one of the most commonly reported and challenging symptoms after traumatic brain injury. It significantly impacts on well being and quality of life after injury. We will assess fatigue of 120 children who suffer brain injury, from Toronto and Melbourne. This study will improve our understanding of the factors that predict fatigue following brain inju ....This research will examine what factors predict the fatigue children will experience after brain injury. This study is important because fatigue is one of the most commonly reported and challenging symptoms after traumatic brain injury. It significantly impacts on well being and quality of life after injury. We will assess fatigue of 120 children who suffer brain injury, from Toronto and Melbourne. This study will improve our understanding of the factors that predict fatigue following brain injury.Read moreRead less
Communication Recovery In The Initial 12 Months Following Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$77,832.00
Summary
The aims of this study are to learn more about how a person's communication recovers in the first year after a traumatic brain injury. The study will determine what factors may help people with traumatic brain injury recover their communication skills.
Growth factors are essential molecules for normal brain development. Variations in the amount of the different growth factors have been implicated in such diseases as AlzheimerÍs and ParkinsonÍs disease. This project will study the precursor of a growth factor known as brain derived neurotrophic factor (BDNF) and what specific roles the precursor might play in brain development.
Increasing The Use Of Intervention Research Evidence In Acquired Brain Injury Rehabilitation
Funder
National Health and Medical Research Council
Funding Amount
$107,204.00
Summary
Acquired brain injury (ABI) is a major public health issue in Australia, being the leading cause of disability. There is a benefit in clinicians implementing the best available evidence in order to attain best possible outcome after ABI. However, there are persistent gaps between research and clinical practice. This project will synthesise the existing clinical practice guidelines and understand barriers to practicing evidence-based rehabilitation so as to propose a new model of rehabilitation.
Optimising The Motor Outcomes Of Infants With Cerebral Palsy Using Environmental And Goal Oriented Interventions
Funder
National Health and Medical Research Council
Funding Amount
$116,563.00
Summary
Cerebral palsy is the most common physical disability in childhood. Early diagnosis enables intervention when the brain is developing. Current early intervention has little impact on movement. This research tests the effectiveness of “goal-directed training” and enriched environments by: systematically reviewing literature, piloting the intervention, conducting a clinical trial and interviewing parents. Findings have the potential to improve the outcomes of the 700 new cases diagnosed each year.
Down syndrome (DS) individuals have 3 copies of chromosome 21. I am proposing to do my PhD to investigate the role of a gene existing on chromosome 21 called Intersectin 1. This gene, when over-expressed might be responsible for manifestation of intellectual impairment in Down syndrome. I will be examining the consequence of altered/over-expression of this gene in receptor trafficking, cell signalling and histology of the brain to identify the differences between affected individuals and the nor ....Down syndrome (DS) individuals have 3 copies of chromosome 21. I am proposing to do my PhD to investigate the role of a gene existing on chromosome 21 called Intersectin 1. This gene, when over-expressed might be responsible for manifestation of intellectual impairment in Down syndrome. I will be examining the consequence of altered/over-expression of this gene in receptor trafficking, cell signalling and histology of the brain to identify the differences between affected individuals and the normal population.Read moreRead less
Identifying Neuroanatomical Sub-phenotypes Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$60,129.00
Summary
The clinical presentation of schizophrenia is varied across individuals, and has arguably hindered efforts to determine its cause/s. This project seeks to address this issue by investigating biological commonality in patients, to identify subgroups of schizophrenia patients with similar brain abnormalities, with the overall aim to examine cognitive and clinical characteristics and candidate genetic markers in association with biologically derived subtypes of schizophrenia.
Sharpening The Epidemiological Sword Against Ocular Trauma To Help Improve Management And Predict The Visual Outcomes, Contributing To The Development Of Prevention
Funder
National Health and Medical Research Council
Funding Amount
$59,168.00
Summary
Eye injury is the leading cause of monocular blindness internationally. Vision loss has devastating consequences, both financial and social. My research aims to develop a comprehensive international register for eye injury. Working with key international partners we will conduct a large-scale retrospective review to validate our data collection tool. Our aim is to revise outdated methods of scoring eye injury to better predict outcomes and improve management and treatment of eye injury.
What Is The Function Of The Tibialis Posterior Muscle And Tendon During Walking And How Does It Affect Disorders Of The Foot
Funder
National Health and Medical Research Council
Funding Amount
$110,235.00
Summary
The tibialis posterior (TP) muscle is important for foot function and is often implicated in foot and ankle problems. We will investigate the function of TP during gait with specific reference to foot posture. In particular we will examine the mechanical function of the muscle and tendon in different foot postures and commonly used treatment modalities such as (footwear and foot orthoses).
A Systematic Evaluation Of The Neurosurgical Application Of Peri-operative And Intra-operative MR Tractography In Different Paediatric Disease States
Funder
National Health and Medical Research Council
Funding Amount
$130,910.00
Summary
My research investigates changes in brain nerve fibre tracts/white matter in paediatric disease states and changes related to surgery by using nerve fibre tract imaging before, during and after surgery. It will also generate an imaging atlas to help understand white matter pathway development. It then serves as normative comparison to better understand aberrations in diseased neural pathways. The outcome will aid understanding in brain development, recovery and plasticity, and helps improve whit ....My research investigates changes in brain nerve fibre tracts/white matter in paediatric disease states and changes related to surgery by using nerve fibre tract imaging before, during and after surgery. It will also generate an imaging atlas to help understand white matter pathway development. It then serves as normative comparison to better understand aberrations in diseased neural pathways. The outcome will aid understanding in brain development, recovery and plasticity, and helps improve white matter lesion localisation.Read moreRead less