Depressive And Bipolar Disorders: Causes, Presentation And Treatment Innovations
Funder
National Health and Medical Research Council
Funding Amount
$7,100,605.00
Summary
Depression and bipolar disorder are two of Australia’s leading causes of disease burden, with 3-4 million Australians affected during their lifetime. However, despite being such a serious health burden, there are major shortcomings to current understanding and management. This research program aims to further our knowledge of the causes and presentations of the mood disorders, and to improve and “tailor” treatment for the many Australians who suffer from these highly disabling illnesses.
Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Finding New Evidence Based Therapies For Treating Heart Disease And Stimulating Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$11,088,182.00
Summary
Heart disease is the leading cause of death and disability in our society. This interactive team of clinicians and basic scientists will exploit the latest advances in genome technology and stem cell biology to gain greater insights into the genetic basis of heart disease, elucidate the molecular mechanisms of cardiac function and disease and translate these insights into the development of novel therapeutic approaches for the prevention and treatment of heart disease.
MOTOR IMPAIRMENT: Basic And Applied Human Neurophysiology
Funder
National Health and Medical Research Council
Funding Amount
$6,830,980.00
Summary
Motor Impairment results in physical disability in a wide range of debilitating diseases and health conditions. We will conduct a research program that will include both experimental investigations and clinical trials to identify optimal strategies for maximising physical functioning for people with weakness and fatigue, impaired sensation and balance, and contracture. In doing so, our program offers great scope for improving the health and quality of life for millions of Australians and substan ....Motor Impairment results in physical disability in a wide range of debilitating diseases and health conditions. We will conduct a research program that will include both experimental investigations and clinical trials to identify optimal strategies for maximising physical functioning for people with weakness and fatigue, impaired sensation and balance, and contracture. In doing so, our program offers great scope for improving the health and quality of life for millions of Australians and substantially reducing health care costs.Read moreRead less