Gene Mining For Novel Molecular Determinants Of The Skeleton
Funder
National Health and Medical Research Council
Funding Amount
$633,447.00
Summary
Musculoskeletal conditions affect over 6 million Australians and research has shown that genetic background strongly influences development of these disorders. This project will identify genes that have a role in controlling bone and joint architecture. Identification of these genes will assist in the development of treatments targeting bone disorders and allow screening for these genes to provide an opportunity for people to take preventative action to improve bone and joint health.
Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions w ....Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions will be re-evaluated in the context of contemporary economic, social and environmental criteria to enable existing multi-criteria models to deliver more sustainable outcomes that are also feasible and in the national interest, and consequently minimise the industry's current exposure to future climate change.Read moreRead less
Understanding and preventing workforce vulnerabilities in midlife and beyond. This project brings together frontline service agencies with researchers from two universities to study involuntary non-participation and under-participation in the labour market by midlife Australians. Quantitative and qualitative approaches will be used to understand pathways and outcomes so as to inform policy and practice responses.
Remembering the Wars: Community Significance of Western Australian War Memorials. The project will provide an enriched understanding of war commemoration, community meanings, the design of war memorials and recommendations of practical strategies for their interpretation and conservation. The research from this project will add to the social understanding of our national war commemorative practices, the connections between community meaning and memorial design and the importance of war memorials ....Remembering the Wars: Community Significance of Western Australian War Memorials. The project will provide an enriched understanding of war commemoration, community meanings, the design of war memorials and recommendations of practical strategies for their interpretation and conservation. The research from this project will add to the social understanding of our national war commemorative practices, the connections between community meaning and memorial design and the importance of war memorials as instruments of citizenship. Results will be used to formulate a strategy to raise regional community awareness and regard for local war memorials through publications and through the direct action of local RSL Branches and community interest groups with a view to application on a national scale through the RSL. Read moreRead less
ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for ....ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for and make better decisions for an ageing world, with consequent social and economic benefits for families and communities expected to flow to Australia, the Asian region and the world.Read moreRead less
Making Music Work: Sustainable Portfolio Careers for Australian Musicians. This project plans to explore the conditions and strategies needed for musicians to sustain successful portfolio careers. Most musicians have ‘portfolio careers’, combining aspects of performance, recording, creation, music direction, teaching, community activities, health, retail and a presence in online environments. This phenomenon — often across music genres — is widespread but not well understood. The project involve ....Making Music Work: Sustainable Portfolio Careers for Australian Musicians. This project plans to explore the conditions and strategies needed for musicians to sustain successful portfolio careers. Most musicians have ‘portfolio careers’, combining aspects of performance, recording, creation, music direction, teaching, community activities, health, retail and a presence in online environments. This phenomenon — often across music genres — is widespread but not well understood. The project involves surveys and 12 in-depth case studies of individual musicians or ensembles that will aim to identify key success factors and obstacles. This information is intended to inform opportunities for training, development and support.Read moreRead less
Catastrophe: a historical and philosophical assessment of urban disaster, ethics and the built environment. This project provides a comprehensive framework for the re-evaluation of civil society in relation to the built environment. It proposes that ‘safeguarding Australia’ and understanding its place in the world can begin by looking at urban planning and architecture, the perceptions that define them, and the catastrophic risks that attend them.
Presumed Guilty: An Economics Analysis of the Efficiency of Environmental Bonds for the WA Mining Sector. Environmental bonds have two important economic effects. First they give an incentive for mining firms to manage environmental damage and second they prevent excessive costs falling on the regulator in the case of bankruptcy. The aim of this project is to assess if this policy can be redesigned to increase its economic efficiency.
Functional Effects Of Polymorphic Variation Of The Aromatase (CYP19) Gene On Enzyme Activity:relationship To Disease
Funder
National Health and Medical Research Council
Funding Amount
$237,708.00
Summary
After menopause, oestrogen synthesis changes from an ovarian to an adipose source by concersion of androgens to estrogens, a process catalyzed by aromatase, the product of the CYP19 gene. We will generate mutants of the CYP19 gene that we have previously found in humans by site-directed mutagenesis and observe the effects of these mutants on aromatase function. This research will help with diagnosis and treatment of breast and other cancers and osteoporosis in humans .
Innovative procurement theories to optimise education per cost of school. Innovative procurement theories to optimise education per cost of school. This project aims to develop a whole-of-life procurement decision-making framework so schools can make delivering better education more cost effective. This framework—which draws on state-of-the-art and Nobel prize-winning theories and a new theory the project will develop—will be used in government and private schools. The effectiveness of this fram ....Innovative procurement theories to optimise education per cost of school. Innovative procurement theories to optimise education per cost of school. This project aims to develop a whole-of-life procurement decision-making framework so schools can make delivering better education more cost effective. This framework—which draws on state-of-the-art and Nobel prize-winning theories and a new theory the project will develop—will be used in government and private schools. The effectiveness of this framework in improving schools will be shown using a new approach to make school facilities deliver educational outcomes and account for their total production and transaction costs. This research is expected to deliver more efficient ways to future-proof schools to create a well performing school system and more resilient infrastructure vital to Australia’s future prosperity.Read moreRead less