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The Role Of Osteocytes In Particle Induced Osteolysis
Funder
National Health and Medical Research Council
Funding Amount
$457,196.00
Summary
Hip replacements often fail due to the loss of adjacent bone. Metal or polyethylene particles are produced as the prosthesis bearing surface wears but how do these particles lead to bone loss? Our work suggests involvement of osteocytes within the bone mineral, which are increasingly understood to drive bone physiology and pathology. We will explore the role of the osteocytes by examining their response to particles, which may identify a new target to prevent particle-induced bone loss.
Determination Of Irradiation Dose Efficacy For Use In Impaction Grafting At Revision Joint Replacement
Funder
National Health and Medical Research Council
Funding Amount
$411,517.00
Summary
Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence ....Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence of early complications of this procedure have included loss of fixation within the bone. Fracture of the bone around prostheses has also reported in some centres. These events require more surgery, putting the patient at higher risk greater complications and longer rehabilitations. Recent improvements in surgical technique and donor bone preparation have improved results. A current debate questions whether the dose of irradiation can be reduced from 25 kGy, while maintaining sterility of allografts. The risk of bacterial contamination in allografts is low, and irradiation reduces the mechanical strength of the graft, contributing to complications when irradiated bone is used. The benefits of decontaminating the bone may be outweighed by the higher risk for failure due to poor bone quality and resulting prosthesis instability. We will use ISO standards to test the validity of radiation dose for sterilising bone ex vivo. In the absence of controlled human studies, our aim is also to compare the results of impaction grafting with non-irradiated bone versus bone irradiated at current doses used by Australian bone banks, and lower doses indicated by ex vivo testing. We will use a large animal model of revision hip replacement, with precise measures of prosthesis stability. The results of this study will guide clinical decisions regarding the efficacy of current bone graft preparation procedures and the use of irradiated bone in human hip replacement surgery.Read moreRead less
We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately exp ....We will seek to address an important clinical problem in orthpaedics, namely the bone loss that commonly occurs around joint replacement prostheses. Termed peri-prosthetic osteolysis (PO), this bone loss can result in the loosening and ultimate failure and need for revision of the artificial joint components. PO is thought to be caused by the body's reaction to wear particles generated from the articulating surface of the prosthesis. However, it has not previously been possible to accurately explore the relationship between prothesis wear and PO, or the progression of PO, because of a lack of techniques to image and measure the volume of PO around metal prosthesis components. We have developed a means to accurately and reproducibly measure the volume of bone loss, using CT, and will do so longitudinally in joint replacement patients to obtain the first information about the progression of PO. New computer based methods will be used concurrently to relate prosthesis wear and migration parameters to PO. Patients who come to surgery for replacement of failed prostheses will be investigated further by analysis of the tissues involved in the bone loss around prostheses. Basic science experiments will seek to understand the underlying causes of PO and the findings will be important in interpreting the clinical results. An animal model will be used to seek approaches to inhibiting the pathological response to wear particles. The significance of these studies is that they will lead to improved outcomes for joint replacement patients, increasing the interval to revision surgery, which is both extremely costly and brings an attendant morbidity and mortality.Read moreRead less
Novel Methods For Promoting Organ Development And Growth
Funder
National Health and Medical Research Council
Funding Amount
$390,203.00
Summary
A revolutionary new therapy for treatment of growth restricted fetuses and premature babies is being developed through the administration of Colony Stimulating Factor (CSF-1). We have evidence that CSF-1 therapy can promote kidneys and lungs to continue development and maturation after birth. This exciting new finding allows for the application of CSF-1 therapy for both the treatment of premature babies and unborn babies with kidney defects.
Regulation Of Key Pathways Causing Peri-implant Bone Loss.
Funder
National Health and Medical Research Council
Funding Amount
$403,639.00
Summary
The failure of bone prostheses is becoming a major health problem in our aging population. Despite the impressive success of joint replacement surgery, a significant number of arthroplasties fail. It is now apparent that most implants fail due to bone loss around them which leads to loosening. This project aims to obtain a better understanding of the causes of implant failure and find ways to extend the life of these implants .
Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e ....Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e-skin) sensors, which are wearable for monitoring blood pulses, body motions and hand gestures in real-time and in situ. This is expected to advance our knowledge in nanotechnology and generate patentable technologies in soft e-skin sensors, and to bring significant scientific and economic gains to Australia.Read moreRead less
Development of functional dendrimer-like inorganic nanomaterials with hierarchical pores for biological applications. This project aims to engineer a series of brand new dendrimer-like mesoporous silica nanoparticles with hierarchical pore structure and favourable surface functionality as nanocarriers to construct a smart delivery system. Unique materials structure and surface functionalisation design can endow the system with advanced characteristics of the co-loading of different therapeutic a ....Development of functional dendrimer-like inorganic nanomaterials with hierarchical pores for biological applications. This project aims to engineer a series of brand new dendrimer-like mesoporous silica nanoparticles with hierarchical pore structure and favourable surface functionality as nanocarriers to construct a smart delivery system. Unique materials structure and surface functionalisation design can endow the system with advanced characteristics of the co-loading of different therapeutic agents and the highly efficient target delivery that are not readily obtainable using other organic or inorganic materials. The proposed delivery systems are of great importance for improving the therapeutic efficiency of complex diseases, and in general, for expanding human’s life span.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775534
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
A liquid chromatograph-mass spectrometer for plant metabolomics. The Australian Agrifood sector will benefit significantly from the establishment of functional genomics platform technologies, such as metabolomics, that underpin 'Systems Biology'; a new branch of biology that attempts to discover and understand biological properties that emerge from the interactions of many system elements. Australian agriculture will benefit through the development of techniques to improve both yield and quality ....A liquid chromatograph-mass spectrometer for plant metabolomics. The Australian Agrifood sector will benefit significantly from the establishment of functional genomics platform technologies, such as metabolomics, that underpin 'Systems Biology'; a new branch of biology that attempts to discover and understand biological properties that emerge from the interactions of many system elements. Australian agriculture will benefit through the development of techniques to improve both yield and quality through minimising the effects of abiotic and biotic stresses, and a reduced dependence on inputs (eg fertilisers) leading to environmentally sustainable production systems. Ultimately this will result in enhanced food quality and analytical methods to monitor quality and safety characteristics of food.Read moreRead less
Special Research Initiatives - Grant ID: SR0354852
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Regions for a Competitive Australia. How can metropolitan, rural and remote regions balance economic and job growth, with environmental and social sustainability? This Initiative establishes a Network of researchers to work collaboratively on questions of environmental best practice, community development, regional governance, labour markets, economic development and technology transfer. The Network's vision is to find ways to use existing and future research to help make Australia ....Sustainable Regions for a Competitive Australia. How can metropolitan, rural and remote regions balance economic and job growth, with environmental and social sustainability? This Initiative establishes a Network of researchers to work collaboratively on questions of environmental best practice, community development, regional governance, labour markets, economic development and technology transfer. The Network's vision is to find ways to use existing and future research to help make Australia's regions more competitive on world markets and more environmentally sustainable, and to help build stronger regional communities. The Network cuts across traditional discipline boundaries to find integrated solutions to the real problems confronting Australian regions.Read moreRead less