Gene Mining For Novel Molecular Determinants Of The Skeleton
Funder
National Health and Medical Research Council
Funding Amount
$633,447.00
Summary
Musculoskeletal conditions affect over 6 million Australians and research has shown that genetic background strongly influences development of these disorders. This project will identify genes that have a role in controlling bone and joint architecture. Identification of these genes will assist in the development of treatments targeting bone disorders and allow screening for these genes to provide an opportunity for people to take preventative action to improve bone and joint health.
Applications of Group Theory to Finite Geometry. Group theory and geometry have influenced one another for over a century. The most important structures in geometry are the symmetric ones and the most important groups act on geometries. Recent developments in finite geometry, although informed by symmetry, have used a minimum of group theory. The project aims to redress this, by applying results from a broad range of finite group theory to the presently hot topics in finite geometry. Our aim is ....Applications of Group Theory to Finite Geometry. Group theory and geometry have influenced one another for over a century. The most important structures in geometry are the symmetric ones and the most important groups act on geometries. Recent developments in finite geometry, although informed by symmetry, have used a minimum of group theory. The project aims to redress this, by applying results from a broad range of finite group theory to the presently hot topics in finite geometry. Our aim is to achieve a paradigm shift, by finding substantively different structures than those presently known. Should it succeed, much activity in geometry would follow, seeking geometric interpretation of these group theoretic results. Our focus is necessitated by the lack of a result characterising the underlying groups of symmetric generalised quadrangles.Read moreRead less
Permutation groups and their interplay with symmetry in finite geometry and graph theory. A strong mathematical community in Australia provides the foundations for future discoveries in technology, science and business. The use of group theory to characterise symmetric generalised quadrangles, partial quadrangles, and strongly regular graphs, and the construction of new examples of such objects, will enhance Australia's leading position in Group Theory, Algebraic Graph Theory and Finite Geometry ....Permutation groups and their interplay with symmetry in finite geometry and graph theory. A strong mathematical community in Australia provides the foundations for future discoveries in technology, science and business. The use of group theory to characterise symmetric generalised quadrangles, partial quadrangles, and strongly regular graphs, and the construction of new examples of such objects, will enhance Australia's leading position in Group Theory, Algebraic Graph Theory and Finite Geometry. This project will also strengthen the collaboration between Australian, Belgian and Italian Universities and support young researchers, developing expertise in a world-leading research group, to drive Australia's future in mathematics.Read moreRead less
Functional Effects Of Polymorphic Variation Of The Aromatase (CYP19) Gene On Enzyme Activity:relationship To Disease
Funder
National Health and Medical Research Council
Funding Amount
$237,708.00
Summary
After menopause, oestrogen synthesis changes from an ovarian to an adipose source by concersion of androgens to estrogens, a process catalyzed by aromatase, the product of the CYP19 gene. We will generate mutants of the CYP19 gene that we have previously found in humans by site-directed mutagenesis and observe the effects of these mutants on aromatase function. This research will help with diagnosis and treatment of breast and other cancers and osteoporosis in humans .
Finite permutation groups and flag-transitive incidence structures. Mathematics is the enabling discipline for all the sciences and so a strong mathematical research community in Australia provides the foundations for future discoveries in science and technology. By developing new theory for permutation groups, producing a new paradigm for the study of Buekenhout geometries and classifying certain families of flag-transitive incidence structures, we will enhance Australia's leading position in P ....Finite permutation groups and flag-transitive incidence structures. Mathematics is the enabling discipline for all the sciences and so a strong mathematical research community in Australia provides the foundations for future discoveries in science and technology. By developing new theory for permutation groups, producing a new paradigm for the study of Buekenhout geometries and classifying certain families of flag-transitive incidence structures, we will enhance Australia's leading position in Permutation Group Theory, Algebraic Graph Theory and Finite Geometry. This will attract international and Australian postgraduate students and visitors, and strengthen the research activities of Australia by enhancing the collaboration between UWA and leading international universities.Read moreRead less