Bioactive And Biodegradable Scaffold And Novel Graft Source For The Repair Of Large Segmental Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$451,103.00
Summary
The treatment of large bone defects arising from trauma and tumour remains a challenge to orthopaedic surgeons. This project combines a well-established scaffold that can be custom-made to address patient specific requirements with a novel source of graft that can be harvested in significant volumes with minimal pain and morbidity. This novel tissue engineering approach will be evaluated in a previously established pre-clinical model that reflects the severity of challenging clinical scenarios.
Pre-clinical Validation Of A Novel Implant For Bone Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$435,767.00
Summary
The aim of this grant to was examine a new method for manufacturing implants to improve repair of critical bone defects. It involves new technology for the manufacture of porous scaffolds and testing their delivery in a biological, bone repair setting.
Novel Strategy For The Treatment Of Large Bone Defects Using A Unique Biomaterial With Tailored Microstructure
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
There is a rapidly increasing and pressing medical need for the development of synthetic implants that can regenerate large amounts of lost or diseased bone. This project will produce a unique implant with optimal mechanical and biological performance, which represents a viable alternative to bone grafting with broad applications for the repair of large or challenging bone defects. Such an achievement will produce significant healthcare benefits and improved long-term outcomes.
HARNESSING THE PHYSIOLOGICAL EFFECTS OF STRONTIUM AND ZINC TO PRODUCE NOVEL BIOMATERIALS FOR ORTHOPAEDIC APPLICATIONS
Funder
National Health and Medical Research Council
Funding Amount
$560,082.00
Summary
Large skeletal defects resulting from congenital defects or disease processes are challenging to regenerate and represent a major financial burden to our health system. Bone graft treatments are widely used but have considerable drawbacks. Available synthetic alternatives lack the physical-biological properties necessary. We have developed new scaffolds with improved mechanical-biological properties for bone regeneration.
The emerging interdisciplinary field, mechanobiology, is focused on understanding how cells sense their surroundings and transfer biomechanical signals to initiate cellular changes. I aim to develop hydrogel platforms with differential stiffness patterns to study cellular mechanotransduction and to generate heart muscle cells. The findings have the potential to greatly improve the clinical outcomes where more than 10 clinical trials failed to show successful regeneration after heart attack.
Functional Nano-cement Scaffolds For The Treatment Of Osteoporotic Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
Innovative Antimicrobial Treatments For Successful Bone Allografts
Funder
National Health and Medical Research Council
Funding Amount
$473,706.00
Summary
Bone healing sites are commonly infected, and this is associated with adverse clinical and significant socioeconomic outcomes. These studies will determine whether our novel antimicrobials can be used to reduce bone infections by studying the combination of antimicrobials and bone in laboratory and bone fracture studies whilst minimising the potential of developing antibiotic resistance.
Novel Biocompatible Nickel-free Shape Memory Alloy Scaffolds For Biomedical Applications
Funder
National Health and Medical Research Council
Funding Amount
$530,789.00
Summary
The current project is aimed at the development of a new class of novel biocompatible nickel-free shape memory alloy (SMA) scaffolds for metallic implant applications. The new scaffolds possess the ability to exert a mechanical force on the surrounding bones, and stimulate new bone tissue ingrowth, due to their shape memory effect, superelasticity and bone-mimicking porous structure. The outcomes from this project will provide innovative implant materials.
Development Of Gene-activated Scaffolds As Bone Bioreactor For Bone Regeneration And Osteointegration
Funder
National Health and Medical Research Council
Funding Amount
$215,100.00
Summary
The worldwide market for bone substitutes has been estimated at over US $1 billion annually. The emerging technology of cell based therapy has opened a new window for the treatment of bone defects. This project is to develop gene-activated scaffolds able to induce blood vessel formation thus improving the local nutrition supply, and subsequently stimulating bone formation in bone defects, as well as osteointegration around implant surface. The knowledge generated from this project will help the ....The worldwide market for bone substitutes has been estimated at over US $1 billion annually. The emerging technology of cell based therapy has opened a new window for the treatment of bone defects. This project is to develop gene-activated scaffolds able to induce blood vessel formation thus improving the local nutrition supply, and subsequently stimulating bone formation in bone defects, as well as osteointegration around implant surface. The knowledge generated from this project will help the treatment of a number of orthopaedic and dental conditions.Read moreRead less
A Novel Strategy For The Treatment Of Chronic Skeletal Joint Defects
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Skeletal joint injuries often heal poorly with current treatment approaches and lead to the onset of osteoarthritis. This project will produce a synthetic graft with unique properties to mimic the complex structure of joint tissues, and high bioactivity to induce optimal healing of the joint. This graft will constitute a viable alternative for the treatment of skeletal joint defects, resulting in significant healthcare benefits and improved long-term outcomes.