Improving Weight Loss By Intermittent Use Of Very Low Energy Diet: The TANGO Diet Trial (Temporary Phases Of Accelerated Weight Loss For Noticeably Greater Outcomes)
Funder
National Health and Medical Research Council
Funding Amount
$660,736.00
Summary
Very low energy diet (VLED) is being increasingly used for the treatment of obesity, but the resultant weight loss is usually transient, partly because it induces powerful adaptive responses that inhibit weight loss and promote regain. We have shown that 'taking a break from dieting' for 2 weeks reduces these adaptive responses. In this project we will thus test whether weight loss outcomes with VLED can be improved via intermittent use, where periods on the VLED are alternated with 'breaks'.
Impact Of An Ivermectin Mass Drug Administration Program Against Endemic Scabies And Strongyloidiasis
Funder
National Health and Medical Research Council
Funding Amount
$1,289,786.00
Summary
Overseas studies suggest sustainable and long term benefits can be obtained through the use of ivermectin in mass drug administration programs to control parasitic infections. Our study will be a critical first step in establishing if such a program can be successful in a remote Indigenous community setting, where the disease burden from scabies and strongyloidiasis (threadworm infections) is very high.
Thermal enhancement strategies and development of a high-performance micro-scale heat exchanger for thermoelectric refrigeration with large cooling loads. Traditional refrigeration essentially utilises CFC-refrigerants which are potent atmospheric pollutants causing widespread ecological damage. Devoid of such adversities, electronic heat pumping mechanism of thermoelectric principle offers a practical ?CFC-free? alternative for conventional cooling methods. While the current thermoelectric te ....Thermal enhancement strategies and development of a high-performance micro-scale heat exchanger for thermoelectric refrigeration with large cooling loads. Traditional refrigeration essentially utilises CFC-refrigerants which are potent atmospheric pollutants causing widespread ecological damage. Devoid of such adversities, electronic heat pumping mechanism of thermoelectric principle offers a practical ?CFC-free? alternative for conventional cooling methods. While the current thermoelectric technology adequately meets light cooling demand, its potential for heavy-duty refrigeration is critically undermined by ill-developed methods for dissipating heat from thermoelectric modules to coolants, and remains grossly under-utilised. The proposed work will devise novel heat transfer techniques for raising thermoelectric cooling thresholds to suit large heat loads and develop a thermally enhanced micro-scale heat exchanger for application in commercial thermoelectric refrigeration.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101533
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
A risk-based approach to natural gas hydrates in oil and gas production. Like a cholesterol for oil and gas pipelines, gas hydrates are ice-like deposits that completely block the flow during production and are expensive to prevent as well as dangerous to remove. This proposal provides a risk-based approach to hydrate management that will increase the viability of natural gas production from fields in deep water.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100174
Funder
Australian Research Council
Funding Amount
$193,000.00
Summary
Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be i ....Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be integrated with a specialised Raman imaging microscope to study crystallisation, mass transfer and molecular exchange, in application areas including energy transport, carbon capture and storage, and protein nucleation. This project is expected to open new avenues in engineering, chemistry and physics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101094
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Precision Spectroscopy of CO2 Exchange in Hydrates for Clean Energy Production. Carbon dioxide capture and sequestration is a widely considered climate change mitigation strategy. Clathrate hydrates of natural gas, found in deep-water ocean sediments, represent a tremendous opportunity for simultaneous carbon dioxide sequestration and clean energy production. By injecting carbon dioxide into the hydrate reservoir, methane can be displaced and replaced by carbon dioxide. This project will use Ram ....Precision Spectroscopy of CO2 Exchange in Hydrates for Clean Energy Production. Carbon dioxide capture and sequestration is a widely considered climate change mitigation strategy. Clathrate hydrates of natural gas, found in deep-water ocean sediments, represent a tremendous opportunity for simultaneous carbon dioxide sequestration and clean energy production. By injecting carbon dioxide into the hydrate reservoir, methane can be displaced and replaced by carbon dioxide. This project will use Raman spectroscopy and nuclear magnetic resonance imaged core-flood experiments to develop a fundamental understanding of the exchange mechanisms governing the replacement of the methane molecule in the hydrate cage with carbon dioxide. This knowledge will be critical for future development of these resources to safely extract methane from sub-sea hydrates.Read moreRead less
Heat Transfer Mechanisms in an Indirectly Fired Rotary Kiln with Lifters and Its Role in Scaling. This project will apply heat transfer principles to improve and optimise the design and performance of ANSAC's innovative kiln technology for a wide range of process applications. By understanding the mechanisms of heat transfer involved in the working of the proprietary technology, major factors limiting the performance of the kiln can be identified, resulting in design criteria that link key opera ....Heat Transfer Mechanisms in an Indirectly Fired Rotary Kiln with Lifters and Its Role in Scaling. This project will apply heat transfer principles to improve and optimise the design and performance of ANSAC's innovative kiln technology for a wide range of process applications. By understanding the mechanisms of heat transfer involved in the working of the proprietary technology, major factors limiting the performance of the kiln can be identified, resulting in design criteria that link key operating parameters for the kiln scaling and performance forecast. The research outcomes will provide a scientific basis that underpins the development of an Australian technology and supports the growth of a new Australian small business, creating employment opportunities within Australia.Read moreRead less
Near zero-emission hydrogen and carbon production from natural gas and bio-methane. Hydrogen is envisaged as a clean fuel for power generation particularly for the transportation sector. In the short- and mid-term future, hydrogen will be derived from fossil fuels. Based on the conventional processes, the route from fossil fuels to hydrogen invariably produces greenhouse gases. Geosequestration is a viable technique of storing carbon dioxide but has an uncertain long-term environmental ramifi ....Near zero-emission hydrogen and carbon production from natural gas and bio-methane. Hydrogen is envisaged as a clean fuel for power generation particularly for the transportation sector. In the short- and mid-term future, hydrogen will be derived from fossil fuels. Based on the conventional processes, the route from fossil fuels to hydrogen invariably produces greenhouse gases. Geosequestration is a viable technique of storing carbon dioxide but has an uncertain long-term environmental ramification. In contrast, our proposed technique avoids the production of greenhouse gases and, instead, engenders high value added graphitized carbon as a by-product. Given the relative stability and value of graphitized carbon, our catalytic cracking process provides another option to geosequestration.Read moreRead less
Carbon dioxide-methane exchange in porous media for carbon-neutral energy production. This project aims to incorporate carbon capture and storage into natural gas production from energy reserves. Carbon sequestration could assist in achieving the goals of the Paris Climate Agreement. Injecting carbon dioxide into natural gas reservoirs or methane hydrate sands would be a nearly carbon-neutral means of energy production. However, this exchange of carbon dioxide for methane is poorly understood in ....Carbon dioxide-methane exchange in porous media for carbon-neutral energy production. This project aims to incorporate carbon capture and storage into natural gas production from energy reserves. Carbon sequestration could assist in achieving the goals of the Paris Climate Agreement. Injecting carbon dioxide into natural gas reservoirs or methane hydrate sands would be a nearly carbon-neutral means of energy production. However, this exchange of carbon dioxide for methane is poorly understood in both reservoirs and sands because multiple phases like water and sand affect mixing and recovery. This project will combine spatially-resolved Magnetic Resonance Imaging of high-pressure flooding and exchange experiments with multi-scale modelling. The expected outcome is simultaneous carbon dioxide sequestration with enhanced energy production.Read moreRead less
Antigen Selection In The MHC-restricted Cellular Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$175,570.00
Summary
The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally appare ....The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally apparent when molecules called antigens are released by microorganisms and captured by the body's cells. This activates lymphocytes resulting in an immune response capable of eliminating the microorganisms. Scrutiny of the body's cells by lymphocytes occurs continuously even when there is no infection present in the body. Following infection of a cell, microbial antigens reveal the infection by their appearance on the cell surface where they are detected by the immune system's lymphocytes. This occurs through a mechanism called antigen presentation. During antigen presentation the proteins inside the cell, including those of any invading microorganism, are first degraded into shorter molecules called peptides. This event is called antigen processing. A fraction of the peptides created by antigen processing are captured by specialised receptors present on all cells. These receptors are called HLA or histocompatibility molecules. This project examines the molecular events which mediate the capture of peptide antigens by HLA molecules. The main focus is on those peptide antigens which elicit killer T cell responses by the immune system. A knowledge of how these peptides are selected for presentation and how they are captured and carried to the cell surface is fundamental to understanding immune responses to microorganisms, tumours, allergens, transplants and self tissues as in autoimmunity. Therefore the study is of great general relevance.Read moreRead less