International Strategies To Reduce Population Salt Intake
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Effective, sustainable and scalable strategies to reduce salt are needed so countries can achieve the global target to reduce salt by 30% by 2025. This research program will support the optimal development of such strategies through trials and intervention research projects, supplemented through a series of systematic reviews and feasibility and cost-effectiveness assessments. The main outcome will be new evidence on the effectiveness of different interventions to support translation globally.
A pressure pulse may be felt at the wrist with every heart beat. New technology allows the analysis of this pulse and provides information that may help doctors make decisions about a patients risk related to blood pressure as well as the effect of drug treatment. The research aims to determine the clinical significance of pressure pulse analysis at rest and during light exercise. It is expected that the new technology will improve the way people with high blood pressure are treated.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
Central Blood Pressure And Cardiovascular Risk In Children Within The General Population And After Repair Of Congenital Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
With an exceptional research standing internationally, and as the leader of a Cardiovascular Bioengineering team, I am developing a new method for assessing central blood pressure in children that will provide better information about early risk of cardiovascular disease than arm blood pressure. This will be applied (1) in a large health study of Australian children and (2) to identify risks and causes of adult-type cardiovascular disease in children with repaired congenital heart disease.
Investigation Of Haematopoietic And Leukemia Stem Cell Self-renewal.
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
The blood stem cell properties of self-renewal and multipotency allows for the constant replenishment of all blood components. Blood cancer stem cells use self-renewal to propagate disease, and can enter a quiescent-dormant phase to evade treatment. My research focuses on the identification and mechanisms of new genes that govern these unique blood stem cell properties, and to investigate whether these genes are also important in blood cancers.