Does Placental Transfusion Prevent Death And Disability In Very Preterm Infants? Childhood Follow Up In The NHMRC Australian Placental Transfusion Study.
Funder
National Health and Medical Research Council
Funding Amount
$889,406.00
Summary
A million babies are born before 30 weeks gestation worldwide each year. Many die or face a lifetime of disability. Enhancing placental transfusion in these infants by deferred clamping of the umbilical cord (DCC) is a simple procedure that may reduce mortality and major disability in childhood. The Australian Placental Transfusion Study (APTS), the largest ever RCT of deferred clamping, will follow up 1200 children born preterm to evaluate if DCC has childhood benefits at 2 years age.
Should Very Premature Babies Receive A Placental Transfusion At Birth? A Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$2,875,774.00
Summary
Premature babies under 30 weeks gestation are up to a hundred times more likely than full term babies to die or survive with major disability, often from brain damage due to poor blood flow after birth. This randomised study will find out if giving them more placental blood at birth, by means of a delay in clamping the umbilical cord, then milking it, reduces anemia, blood transfusions, brain damage, infection, death and disability. The results may benefit millions of premature babies worldwide.
Reducing Morbidities In Preterm Growth Restricted Neonates.
Funder
National Health and Medical Research Council
Funding Amount
$687,214.00
Summary
Intrauterine growth restriction (IUGR) is a serious complication of pregnancy and occurs when fetal growth is abnormal, resulting in a fetus that is smaller than it should be for its given gestational age. IUGR babies are at much greater risk of many short and long-term adverse outcomes. This study investigates the role that adverse cardiovascular development plays in the progression of lung, heart and brain disease in preterm IUGR newborns.
In What Position Should We Be Sleeping Preterm Infants In The NICU?
Funder
National Health and Medical Research Council
Funding Amount
$409,742.00
Summary
Preterm babies are at risk of brain injury caused by low cerebral blood flow and oxygenation. The prone sleeping position (lying on abdomen) has been found to decrease both cerebral oxygenation and blood pressure in healthy term babies, and is a major risk factor for Sudden Infant Death Syndrome. However, it is common practice for preterm babies to be slept in the prone position.This study will examine the effects of prone vs supine positions on brain oxygenation in the preterm babies.
A Pre-clinical Trial Of Early Blood Transfusion For Improving Cerebral Oxygen Delivery In Very Preterm Neonates
Funder
National Health and Medical Research Council
Funding Amount
$970,603.00
Summary
Long-term disability is common in babies born prematurely. This may be due to insufficient delivery of oxygen to the brain, but currently there is no treatment that increases oxygen delivery to the brain. We will determine if blood transfusion is more effective than current treatments given to prevent brain injury in preterm babies. Transfusion has two benefits. It will increase the amount of blood going to the brain. It will also increase the amount of oxygen carried by the blood.