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This study will provide highly reliable information about the use of tight blood glucose control in critically ill patients. It involves an international collaboration between opinion leaders in this field and uses sophisticated statistical methods to combine data from all the clinical trials in this area. The study will clarify many of the current clinical questions about tight glucose control during critical illness, informing practice guidelines in Australia and around the world.
A Factorial Randomised Trial Of Intensive Blood Pressure Lowering And Glucose Control In Subjects With Type 2 Diabetes.
Funder
National Health and Medical Research Council
Funding Amount
$303,330.00
Summary
People with diabetes are well known to be at high risk of developing major health problems earlier in life than people without diabetes. In particular, people with diabetes are more likely to suffer from heart attacks, stroke, blindness, kidney failure and leg ulcers that may lead to amputation. Studies of diabetics have shown that if blood pressure levels or glucose levels are uncontrolled, the risk of complications is much higher. Careful management of these two risk factors is therefore now a ....People with diabetes are well known to be at high risk of developing major health problems earlier in life than people without diabetes. In particular, people with diabetes are more likely to suffer from heart attacks, stroke, blindness, kidney failure and leg ulcers that may lead to amputation. Studies of diabetics have shown that if blood pressure levels or glucose levels are uncontrolled, the risk of complications is much higher. Careful management of these two risk factors is therefore now a cornerstone of diabetic care and there are well-established guidelines for treatment. However, there is new evidence to suggest that tighter control of blood pressure and glucose levels than is currently recommended might result in even greater benefits. ADVANCE (Action in Diabetes and Vascular Disease) is a large new study that has been designed by Australian researchers based at the Institute for International Health in Sydney. The aim of ADVANCE is to see if treatment to control blood pressure and glucose levels more tightly than usual reduces the risk of complications among adult diabetics. The study will include 10,000 individuals recruited from about 20 countries worldwide that will be followed for an average of 4.5 years. The first participants will be enrolled in April 2001 and the study results should be available by the end of 2006. There are presently about 300 million people in the world with diabetes and this number is increasing rapidly. The results of ADVANCE will therefore influence the care of a very large number of people. If the findings of the study were positive, implementation of the new treatments could be expected to prevent many tens of thousands of premature heart attacks and strokes around the world each year.Read moreRead less
Type 2 diabetes causes significant health problems. The fundamental reasons underlying this disease are not fully known and will require molecular analysis of proteins critical to blood glucose control. This work aims to define a novel pathway that responds to circulating nutrients. The research will enhance our understanding of the links between diet and metabolic disease, with potential to reveal much needed therapeutic targets and/or dietary interventions for the treatment of Type 2 diabetes.
Blood Pressure Lowering In Patients With Chronic Kidney Disease: Evidence From Prospectively Planned Overview Analyses
Funder
National Health and Medical Research Council
Funding Amount
$257,271.00
Summary
This study will provide highly reliable information about the best way of managing blood pressure in people with chronic kidney disease. It will use sophisticated methods to summarize information from 25 large clinical trials and 160,000 participants to determine whether lowering blood pressure reduces the risk of heart disease and further kidney damage.The study will also determine whether currently recommended blood pressure drugs are those which will provide the most benefit.
Glucose, Glucose Transporters And Blastocyst Formation In The Mouse
Funder
National Health and Medical Research Council
Funding Amount
$281,650.00
Summary
Embryo-based biotechnologies have the potential to improve human reproductive health, notably in treating infertility by In vitro fertilisation (IVF). They are also central to the future use of embryonic stem cells for human tissue replacement. This project investigates the molecular mechanisms controlling one of the earliest differentiations in the growth of the embryo. Using the mouse as an experimental model it will investigate the importance of several factors in the changes which set up the ....Embryo-based biotechnologies have the potential to improve human reproductive health, notably in treating infertility by In vitro fertilisation (IVF). They are also central to the future use of embryonic stem cells for human tissue replacement. This project investigates the molecular mechanisms controlling one of the earliest differentiations in the growth of the embryo. Using the mouse as an experimental model it will investigate the importance of several factors in the changes which set up the placenta and fetus as seperate tissues in the very early embryo. A key focus is the supply of glucose to the newly fertilised embryo and how important this glucose supply is for the survival of the embryo. Moreover there is great interest in the possibility that metabolic events in utero can contribute to the development of diseases in later life, notably, coronary heart diease, stroke, high blood pressure and non-insulin dependent diabetes. The results from these studies will contribute to our understanding of why some couples are infertile, lead to improved management of infertility by diet and invitro fertilisation procedures. It will also be of benefit in dietary advice to women with diabetes mellitus, seeking to have children. The adenoviral strategy for gene delivery into early mouse embryos may in the long term also find wide clinical application in the treatment of genetic defects at the very earliest stages in development and as such is of enormous potential benefit in the management of both animal and human reproduction.Read moreRead less