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Restoration Of Cognitive Deficits Induced By Diabetes Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$261,251.00
Summary
Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's intern ....Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's international standing in the field of advanced medical imaging and have the potential to be commercialised within the Australian biotechnology sector. During the project, research students will receive high quality multidisciplinary training ensuring the supply of personnel with high-level technical expertise into the future.Read moreRead less
Dementia Associated To Diabetes: Prevention Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$719,770.00
Summary
Diabetic insulin resistance is reported to induce cognitive decline and dementia. An accumulating body of evidence suggest that compromised integrity of neurovascular unit and following changes in cerebral lipid homeostasis may be centrally involved in the neurodegeneration and cognitive deficits. Therefore, the project aims to prevent the insulin resistance-associated cognitive impairment by modulating the integrity of cerebrovasculature and lipid homeostasis.
The Effect Of Selected Nutraceuticals On Brain Blood Vessels And Memory.
Funder
National Health and Medical Research Council
Funding Amount
$445,206.00
Summary
The human brain receives 1000L of blood per day, distributed through minute vessels called capillaries. The integrity and function of brain capillaries is compromised with aging and this may contribute to memory disturbances. Our laboratory has identified several naturally occurring compounds that prevent age-associated defects of brain capillaries. The primary aim of this project is to explore if these agents are beneficial for restoring brain capillary function and memory.
Understanding The Acute And Cumulative Metabolic Effects Of Prolonged Sitting In Adults
Funder
National Health and Medical Research Council
Funding Amount
$416,597.00
Summary
Sedentary behaviour (sitting time) has been linked to an increased risk of chronic illnesses, including type 2 diabetes and obesity, but recent evidence suggests that light-intensity activity (non-exercise activities of daily living) is associated with reduced risk. These studies will examine whether breaking up sitting time with frequent short periods of activity can overcome the negative effects of prolonged sitting on blood glucose and blood fats in overweight older adults.
Learning Mechanisms and the Development of Dynamic Capabilities within Firms. The project has the following national/community benefits: (1) a more comprehensive study of the specific and unique features of the structure and innovative process operating within a major Australian producer of commodities, (2) a greater understanding of how knowledge can be created and captured in the form of firm-level dynamic capabilities, contributing towards the creation of an effective knowledge and innovation ....Learning Mechanisms and the Development of Dynamic Capabilities within Firms. The project has the following national/community benefits: (1) a more comprehensive study of the specific and unique features of the structure and innovative process operating within a major Australian producer of commodities, (2) a greater understanding of how knowledge can be created and captured in the form of firm-level dynamic capabilities, contributing towards the creation of an effective knowledge and innovation economy, and (3) assisting regional communities by providing specific recommendations for generating learning mechanisms and more importantly, capturing value from learning in terms of process improvement and innovation.Read moreRead less
The link between corporate governance and sustainability: A contingency approach. Australian businesses will experience decreased economic growth, more health issues and fewer international opportunities if sustainability is not addressed. Sustainability is business approach seeking long-term value by embracing opportunities and managing risk from economic, environmental and social developments. This study will provide insight into optimal board structures to oversee performance across economic, ....The link between corporate governance and sustainability: A contingency approach. Australian businesses will experience decreased economic growth, more health issues and fewer international opportunities if sustainability is not addressed. Sustainability is business approach seeking long-term value by embracing opportunities and managing risk from economic, environmental and social developments. This study will provide insight into optimal board structures to oversee performance across economic, environmental and social dimensions. It will also identify the conditions whereby firms can adapt to market transformation, and determine resource reconfigurations that respond to sustainability challenges.Read moreRead less
Innovative approaches to managing and understanding taste and odour in drinking water systems. Taste and odour (T/O) problems resulting from Cyanobacteria can change consumers' perception of product safety, resulting in many complaints, soaring management and treatment costs, and large financial losses, yet little is known about how they arise.
This project will provide the Australian Water Industry with cost-effective, sensitive, specific, rapid and practical tools for managing and understandi ....Innovative approaches to managing and understanding taste and odour in drinking water systems. Taste and odour (T/O) problems resulting from Cyanobacteria can change consumers' perception of product safety, resulting in many complaints, soaring management and treatment costs, and large financial losses, yet little is known about how they arise.
This project will provide the Australian Water Industry with cost-effective, sensitive, specific, rapid and practical tools for managing and understanding T/O episodes, and will also benefit the aquaculture and food sectors, and the research community. An improved ability to manage geosmin in drinking water, will also have positive repercussions on the Australian environment, by eliminating the need to use environmentally controversial control methods such as copper sulphate dosing.
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A multilevel approach to leadership and dynamic capabilities in organisations. The quality of leadership in Australian organisations has an impact on business productivity, international competitiveness, and employee health and well-being. This research will support the development of leadership skills at different organisational levels. For senior leaders, these skills include developing strategy, allocating resources, and supporting innovation. For team leaders, skills include team coordinatio ....A multilevel approach to leadership and dynamic capabilities in organisations. The quality of leadership in Australian organisations has an impact on business productivity, international competitiveness, and employee health and well-being. This research will support the development of leadership skills at different organisational levels. For senior leaders, these skills include developing strategy, allocating resources, and supporting innovation. For team leaders, skills include team coordination, employee support, and creating flexibility. By supporting interventions that build adaptivity and flexibility in organisations, the research will provide resources to support dynamic organisations to be better equipped to compete in demanding international markets.Read moreRead less