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Cerebral Circulation In Sleep: Impact Of Endothelial Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$313,026.00
Summary
Prolonged, repetitive episodes of obstructed breathing during sleep (known as obstructive sleep apnoea syndrome or OSA) is a common medical problem that afflicts both children and adults. As many as 200,000 Australian adults and 300,000 children are affected. OSA has major medical consequences, amongst the most serious being cognitive deficits in children and vascular disease and stroke in adults. This experimental study investigates blood flow to the brain in normal sleep, and in sleep disrupte ....Prolonged, repetitive episodes of obstructed breathing during sleep (known as obstructive sleep apnoea syndrome or OSA) is a common medical problem that afflicts both children and adults. As many as 200,000 Australian adults and 300,000 children are affected. OSA has major medical consequences, amongst the most serious being cognitive deficits in children and vascular disease and stroke in adults. This experimental study investigates blood flow to the brain in normal sleep, and in sleep disrupted OSA, as many of the problems associated with OSA may have their origin in disturbance of blood flow to the brain.Read moreRead less
Restoration Of Cognitive Deficits Induced By Diabetes Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$261,251.00
Summary
Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.
New Insights Into Diabetes, Cerebrovascular Integrity And Dementia Risk
Funder
National Health and Medical Research Council
Funding Amount
$307,946.00
Summary
Studies report that subjects with diabetic insulin resistance are at higher risk of developing dementia. Recent data suggest that disturbances in specialized blood vessels of the brain are responsible for the association between diabetes and dementia. This project will utilize state-of-art methodologies to visually explore if drugs commonly used to treat diabetes, provide cerebrovascular benefits.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
Dementia Associated To Diabetes: Prevention Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$719,770.00
Summary
Diabetic insulin resistance is reported to induce cognitive decline and dementia. An accumulating body of evidence suggest that compromised integrity of neurovascular unit and following changes in cerebral lipid homeostasis may be centrally involved in the neurodegeneration and cognitive deficits. Therefore, the project aims to prevent the insulin resistance-associated cognitive impairment by modulating the integrity of cerebrovasculature and lipid homeostasis.