Innovative Technology for At-Scene Forensic Analysis using Microfluidics and Chemiluminescence. The major outcome of this project will be innovative reagents and strategies optimised for the detection of priority analytes such as drugs, explosives and chemical warfare agents. These will utilise a new technology platform based upon laboratory on a chip/microfluidics to enable the development of analytical methodologies suitable for use at crime scenes.This programme of research falls within a Nat ....Innovative Technology for At-Scene Forensic Analysis using Microfluidics and Chemiluminescence. The major outcome of this project will be innovative reagents and strategies optimised for the detection of priority analytes such as drugs, explosives and chemical warfare agents. These will utilise a new technology platform based upon laboratory on a chip/microfluidics to enable the development of analytical methodologies suitable for use at crime scenes.This programme of research falls within a National Research Priority namely 'Protecting Australia from terrorism and crime'. Through our current forensic science research collaboration the outcomes will build significantly on Australia's existing strengths in rapid detection using new analytical technologies.Read moreRead less
Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perfo ....Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perform rapid on-site mapping of nutrients and other water quality parameters in large water bodies, intensive scale mapping of effluent mixing and dispersal zones, quick assessment of the impact of dredging and aquaculture, and compliance monitoring in effluent streams.
Read moreRead less
The Application of Polymer Inclusion Membranes for the Removal of Thiocyanate and Cyanide from Gold Ore Processing Wastewaters. The recovery of gold at Stawell Gold Mine can be improved by using cyanide and thiocyanate free water in the milling process. The aim of this research is the development of a novel separation technology for the removal of these two ions from mine wastewater to allow it to be recycled. Novel polymeric materials, known as polymer inclusion membranes (PIMs), which have nev ....The Application of Polymer Inclusion Membranes for the Removal of Thiocyanate and Cyanide from Gold Ore Processing Wastewaters. The recovery of gold at Stawell Gold Mine can be improved by using cyanide and thiocyanate free water in the milling process. The aim of this research is the development of a novel separation technology for the removal of these two ions from mine wastewater to allow it to be recycled. Novel polymeric materials, known as polymer inclusion membranes (PIMs), which have never been used before in industrial separation, will be at the centre of this technology. In addition to increasing gold recovery, this technology is expected to reduce substantially the reliance of the Australian goldmining industry on fresh water. This research will also promote PIM based separation as a viable industrial separation technology, applicable in other areas.Read moreRead less
Phytoextraction approaches for mitigating heavy metal release from unlined and loosely capped rural landfills. Australian rural landfills are used for storing hazardous wastes which contain toxic metals. Impermeable clay caps are often utilized to encapsulate these wastes and prevent release of pollutants into the environment. The integrity of these caps is crucial and requires constant care. The project aims to develop novel approaches which will improve substantially the long-term environmenta ....Phytoextraction approaches for mitigating heavy metal release from unlined and loosely capped rural landfills. Australian rural landfills are used for storing hazardous wastes which contain toxic metals. Impermeable clay caps are often utilized to encapsulate these wastes and prevent release of pollutants into the environment. The integrity of these caps is crucial and requires constant care. The project aims to develop novel approaches which will improve substantially the long-term environmental safety of rural landfills and deliver additional economic benefits. These approaches involve the use of high-value tree crops and plants capable of extracting toxic metals. Utilization of these plants will create a valuable resource on an otherwise derelict area and this will be of considerable local/regional benefit and national significance.Read moreRead less
An autonomous microfluidic analyser for the determination of total phosphorus and nitrogen in aquatic systems. Development of automated monitoring systems capable of extended and remote operation will enable assessment of the effectiveness of water treatment and the impact of nutrient releases on the aquatic environment. Both are important in preserving the quality of existing water resources, and assessing the quality of recycled water, in line with the National Research Priority Environmentall ....An autonomous microfluidic analyser for the determination of total phosphorus and nitrogen in aquatic systems. Development of automated monitoring systems capable of extended and remote operation will enable assessment of the effectiveness of water treatment and the impact of nutrient releases on the aquatic environment. Both are important in preserving the quality of existing water resources, and assessing the quality of recycled water, in line with the National Research Priority Environmentally sustainable Australia, and the Priority Goal, Water - a critical resource. Commercialization of the microfluidic flow analysis system for total N and P will enhance the international competitiveness of Ecotech Pty Ltd and Australia as an exporter of scientific instruments.Read moreRead less
The pollution potential of mercury in legacy biosolids and possibilities for its minimisation by phytoremediation and phytostabilisation approaches. This project will develop: (1) new chemical analysis techniques to study the mercury fate in legacy biosolids which will lead to better understanding of their potential environmental impact; (2) environmentally-benign phytoremediation approaches using native plants to reduce mercury release so the biosolids can be safely used for land applications.
Short silk nanofibre based 3D scaffolds with enhanced biomimicry. This project aims to understand the behaviour of haematopoietic stem cells (HSC) in novel 3D scaffolds based on short silk nanofibres. This will lead to highly functional 3D scaffolding materials that support efficient HSC renewal in vitro. This project aims to overcome the key problem with existing in vitro systems, which lack the morphological and biochemical complexities of native HSC-niche. Since haematopoietic stem cells are ....Short silk nanofibre based 3D scaffolds with enhanced biomimicry. This project aims to understand the behaviour of haematopoietic stem cells (HSC) in novel 3D scaffolds based on short silk nanofibres. This will lead to highly functional 3D scaffolding materials that support efficient HSC renewal in vitro. This project aims to overcome the key problem with existing in vitro systems, which lack the morphological and biochemical complexities of native HSC-niche. Since haematopoietic stem cells are the precursors to all blood cells, this project has the potential of engineering a high yield artificial ‘blood factory’, which will help save the lives of many thousands of people who rely on bone marrow transplants to treat life-threatening illness such as leukaemia.Read moreRead less
Improved cryopreservation protocols for long term storage of platelets. The aim of this project is to characterise human blood platelet deterioration during cold storage and cryopreservation, and accelerate the development of improved long-term storage options. The project expects to generate important new knowledge about how platelets deteriorate during storage, and how such deterioration can be minimized. The expected outcomes are improved methods for long term platelet storage. This should be ....Improved cryopreservation protocols for long term storage of platelets. The aim of this project is to characterise human blood platelet deterioration during cold storage and cryopreservation, and accelerate the development of improved long-term storage options. The project expects to generate important new knowledge about how platelets deteriorate during storage, and how such deterioration can be minimized. The expected outcomes are improved methods for long term platelet storage. This should benefit blood donation services and hospitals by improving platelet delivery to remote locations, reducing wasted blood and the number of donations required, leading to significant financial savings.Read moreRead less
Biomimetic blood bag materials for prolonged platelet storage. Platelet storage is limited to five to seven days before there is a reduction in viable platelets. This results in a continual mismatch between supply and demand resulting in patients in remotes areas or those that have rare phenotypes missing out on platelets. It also results in the wastage of platelets because they expire before they can be used clinically. This project aims to extend the platelet shelf life beyond seven days by de ....Biomimetic blood bag materials for prolonged platelet storage. Platelet storage is limited to five to seven days before there is a reduction in viable platelets. This results in a continual mismatch between supply and demand resulting in patients in remotes areas or those that have rare phenotypes missing out on platelets. It also results in the wastage of platelets because they expire before they can be used clinically. This project aims to extend the platelet shelf life beyond seven days by developing biomimetic blood bag materials that reflect the natural molecular structures of blood vessels through the use of novel synthetic and biological materials. With the realisation of longer platelet storage times, this project aims to have significant impacts on the health and economic benefits of Australians.Read moreRead less
The impact of haemoglobin deferral on blood donors: perceptions, health and non-return. Blood donors are an vital in ensuring the health of the Australian community. However, they are few in number and difficult to recruit. It is crucial to keep existing donors in the system so that Australia has an assured blood supply, not only for the traditional reasons (road trauma, replacement in surgery, treatment of diseases such as cancer), but also to cope with natural disasters, emergent diseases and ....The impact of haemoglobin deferral on blood donors: perceptions, health and non-return. Blood donors are an vital in ensuring the health of the Australian community. However, they are few in number and difficult to recruit. It is crucial to keep existing donors in the system so that Australia has an assured blood supply, not only for the traditional reasons (road trauma, replacement in surgery, treatment of diseases such as cancer), but also to cope with natural disasters, emergent diseases and the potential results of terrorist activities. Apart from providing new information on blood donor behaviour, the project will also contribute to more general knowledge about volunteers in the community and their role in the maintenance and development of health services.Read moreRead less