Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's intern ....Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's international standing in the field of advanced medical imaging and have the potential to be commercialised within the Australian biotechnology sector. During the project, research students will receive high quality multidisciplinary training ensuring the supply of personnel with high-level technical expertise into the future.Read moreRead less
Dynamic CFD Simulations and Scale-Up of Three-Phase Slurry Reactors for Gas-to-Liquid (GTL) Technology. The gas-liquid-solid flow patterns in three-phase slurry bubble column reactors will be studied using experiments and CFD. The effect of various reactor parameters will be studied to develop the scale-up heuristic for the slurry bubble column reactor. The Findings of this study will be used to optimise the reactor system for the offshore natural gas locations of Australia. A successful impleme ....Dynamic CFD Simulations and Scale-Up of Three-Phase Slurry Reactors for Gas-to-Liquid (GTL) Technology. The gas-liquid-solid flow patterns in three-phase slurry bubble column reactors will be studied using experiments and CFD. The effect of various reactor parameters will be studied to develop the scale-up heuristic for the slurry bubble column reactor. The Findings of this study will be used to optimise the reactor system for the offshore natural gas locations of Australia. A successful implementation of this project will bring a huge economic benefit to Australia by utilising the vast amount of remotely located and otherwise unusable stranded natural gas reserves. The project falls within one of National Research Priorities: An Environmentally Sustainable Australia.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
3D printed microchemical devices and systems. This project aims to address the barriers faced by 3D printing in chemistry. 3D printing can create bespoke 3D structures within a fraction of time and cost compared to traditional fabrication. However, its scope in chemistry has been limited by the poor chemical robustness, biotoxicity and low resolution of the 3D printed components. Hence, this project will develop novel gold coating techniques and explore high-resolution 3D printing to overcome th ....3D printed microchemical devices and systems. This project aims to address the barriers faced by 3D printing in chemistry. 3D printing can create bespoke 3D structures within a fraction of time and cost compared to traditional fabrication. However, its scope in chemistry has been limited by the poor chemical robustness, biotoxicity and low resolution of the 3D printed components. Hence, this project will develop novel gold coating techniques and explore high-resolution 3D printing to overcome these challenges. The project should generate commercially significant products (analytical platforms), technology (gold coating) and patents. The developed systems and technologies will address Australian research challenges in advanced manufacturing and enable on-site environmental monitoring.Read moreRead less
3D Hypersonic Shock-Turbulent-Boundary-Layer Interactions. Shock-wave turbulent-boundary-layer interactions occur on hypersonic flight vehicles and can lead to high heating and increased drag. This is a paramount design issue that needs addressing. We aim to understand and quantify fundamental phenomena occurring in such interactions using state-of-the-art instrumentation and wind-tunnel facilities. Surfaces will be heated to realistic flight temperatures to simulate accurately the flight enviro ....3D Hypersonic Shock-Turbulent-Boundary-Layer Interactions. Shock-wave turbulent-boundary-layer interactions occur on hypersonic flight vehicles and can lead to high heating and increased drag. This is a paramount design issue that needs addressing. We aim to understand and quantify fundamental phenomena occurring in such interactions using state-of-the-art instrumentation and wind-tunnel facilities. Surfaces will be heated to realistic flight temperatures to simulate accurately the flight environment and include effects not reproduced with cold models. The effects of 3D features of the interactions will lead to new understanding of how the flow develops through a combination of experiments and numerical simulations. Future designs of hypersonic flight vehicles will benefit from knowledge gained.Read moreRead less
Characterization of erythroid differentiation related factor (EDRF): a novel a-globin binding protein. Hemoglobin, a four-subunit protein comprising two alpha and two beta polypeptide chains, is the essential oxygen transporter found in all mammals. Problems with the synthesis of hemoglobin can give rise to a range of common and serious human disorders, including thalassaemia and anemia. We have discovered a protein, EDRF, that appears to interact directly with alpha-globin (but not beta-globin) ....Characterization of erythroid differentiation related factor (EDRF): a novel a-globin binding protein. Hemoglobin, a four-subunit protein comprising two alpha and two beta polypeptide chains, is the essential oxygen transporter found in all mammals. Problems with the synthesis of hemoglobin can give rise to a range of common and serious human disorders, including thalassaemia and anemia. We have discovered a protein, EDRF, that appears to interact directly with alpha-globin (but not beta-globin) and to play a role in the regulation of hemoglobin production. We now seek to understand the nature of this interaction at a molecular level and mechanistic level.Read moreRead less
Targeting DNA with Dynamic Combinatorial Chemistry. The interaction of molecules with DNA, the molecule that controls genetic information, is fundamental to drug design, diagnosis of disease and the environment. Chemists usually synthesise these molecules in the laboratory. We will use an innovative new approach to producing molecules that interact with DNA, that as fast and efficient and mirrors the processes used by Nature to make natural products. This research may lead to the design of new ....Targeting DNA with Dynamic Combinatorial Chemistry. The interaction of molecules with DNA, the molecule that controls genetic information, is fundamental to drug design, diagnosis of disease and the environment. Chemists usually synthesise these molecules in the laboratory. We will use an innovative new approach to producing molecules that interact with DNA, that as fast and efficient and mirrors the processes used by Nature to make natural products. This research may lead to the design of new therapeutics, diagnostics and applications that will benefit the Australian community, and will provide excellent training of researchers in skills required for employment in the biotechnology and pharmaceutical fields.Read moreRead less
Scaling laws for aerodynamics of moving wings in the Martian atmosphere. This project aims to increase understanding of the aerodynamics of bio-inspired flight in the low-density atmosphere of Mars. The significance of flight in planetary exploration is shown by the ongoing success of the Ingenuity helicopter on Mars, and the Dragonfly rotorcraft planned for use on Titan. Expected outcomes of this project will be innovative numerical modelling techniques validated using local specially designed ....Scaling laws for aerodynamics of moving wings in the Martian atmosphere. This project aims to increase understanding of the aerodynamics of bio-inspired flight in the low-density atmosphere of Mars. The significance of flight in planetary exploration is shown by the ongoing success of the Ingenuity helicopter on Mars, and the Dragonfly rotorcraft planned for use on Titan. Expected outcomes of this project will be innovative numerical modelling techniques validated using local specially designed low-pressure experimental facilities. Benefits will be more accurate design guidance for efficient and robust flapping and rotary wing robotic vehicles for Mars and other space exploration that take advantage of the unique atmospheric conditions, and in placing Australia at the forefront of such design technology.Read moreRead less
Transcriptional regulation of erythropoiesis. The major expected outcome from this proposal will be development of a pipeline for the study of how transcription factors work at a genome level. There will be national benefit in the areas of Frontier Technologies, and Promoting and Maintaining Good Health. There will be specific outcomes with respect to development of tests for human blood diseases, future design of drugs to target the aberrant activities of transcription factors in genetic and de ....Transcriptional regulation of erythropoiesis. The major expected outcome from this proposal will be development of a pipeline for the study of how transcription factors work at a genome level. There will be national benefit in the areas of Frontier Technologies, and Promoting and Maintaining Good Health. There will be specific outcomes with respect to development of tests for human blood diseases, future design of drugs to target the aberrant activities of transcription factors in genetic and degenerative diseases. Also, a strong bridge will be built upon the previous collaborations of the research teams in Brisbane and Pennsylvania, which will facilitate advanced teaching and training of Australian PhD and post-doctoral scientists.Read moreRead less
Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at ....Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at the microscale. A new microscopic fluid physics model will provide data for an innovative neural network framework to optimise the working fluid conditions and microscale design, which could contribute to increased adoption of renewable energy technologies that are supported by microscale heat exchangers.Read moreRead less