SBP1 And Altered Structure And Function Of Malaria-infected Red Blood Cells
Funder
National Health and Medical Research Council
Funding Amount
$439,550.00
Summary
Malaria is a serious disease affecting half the world's population. Every year, more than a million people (mostly children) die as a result of being infected with malaria parasites. Our work will help us to understand how the parasites alter normal human red blood cells and make them stick in organs such as the brain. Preventing the red blood cells from becoming sticky with new drugs will open up new lines of attack to combat this devastating disease.
Exported Malaria Kinases And Red Blood Cell Remodeling
Funder
National Health and Medical Research Council
Funding Amount
$408,710.00
Summary
Malaria is a serious disease affecting half the world's population and every year, more than a million people (mostly children) die as a result of the infection. Our work will help us to understand how malaria parasites alter human red blood cells and make them stick in organs such as the brain. Preventing infected red cells from becoming stiff and sticky by developing new drugs will open up new lines of attack to combat this devastating disease.
Export Of Effector Proteins By P. Falciparum To The Infected Erythrocyte.
Funder
National Health and Medical Research Council
Funding Amount
$196,582.00
Summary
Infection by the malaria parasite has lethal consequences for humans. In order to survive the parasite exports hundreds of proteins to commandeer the erythrocyte. A translocon that mediates such export has been identified and important questions remain unanswered. In this research, I aim to determine the function of one of the major translocon components for export of proteins to the erythrocyte (EXP2) and through this process determine if it is a viable target for anti-malarial drug development ....Infection by the malaria parasite has lethal consequences for humans. In order to survive the parasite exports hundreds of proteins to commandeer the erythrocyte. A translocon that mediates such export has been identified and important questions remain unanswered. In this research, I aim to determine the function of one of the major translocon components for export of proteins to the erythrocyte (EXP2) and through this process determine if it is a viable target for anti-malarial drug development.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.