Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775726
Funder
Australian Research Council
Funding Amount
$306,270.00
Summary
Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizati ....Australian Mirror of the UCSC Genome Database and Browser. Modern medical, biological, agricultural, and environmental research and industries are being transformed by access to genomic information that details the DNA sequence of various species, as well as of different strains and individuals within populations. This information is being generated at an exponentially increasing speed, and requires large computational resources. This facility will provide Australian researchers, R&D organizations and industry with state-of-the-art genomic data storage and analysis capability, which will permit both public and proprietary access, and accelerate Australian research and development in genetic medicine, pharmaceuticals, animal breeding and biodiversity.Read moreRead less
Enhancing sunscreen DNA and photo-ageing protection. Skin damage from UV exposure is costly for individuals and the community, particularly in Australia, where the population has predominantly fair skin. While public campaigns to persuade the population to use sun protection and avoidance have been useful, this project will be the first to extend this approach to deliver a way to reduce sun damage from any UV exposure that does nevertheless occur, by incorporating the active agents into topical ....Enhancing sunscreen DNA and photo-ageing protection. Skin damage from UV exposure is costly for individuals and the community, particularly in Australia, where the population has predominantly fair skin. While public campaigns to persuade the population to use sun protection and avoidance have been useful, this project will be the first to extend this approach to deliver a way to reduce sun damage from any UV exposure that does nevertheless occur, by incorporating the active agents into topical sunscreens or creams for after-sun use. The project will also build infrastructure for translational research on photo-damage, combining world-class facilities for this research with advanced formulation and manufacturing operations.Read moreRead less
Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes o ....Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes of this project are cost-effective and strongly enhanced approaches for biopharmaceuticals recovery, thereby providing significant benefits to accelerate research and development in early stage discovery and manufacture of biologics, therapeutic proteins and vaccines.Read moreRead less
Accelerating pulse breeding using machine learning. Advances in genomics and high throughput phenotyping are generating vast quantities of data that can be applied for crop improvement, however the lack of computational analysis tools and approaches limits the full exploitation of this data. Pulse legumes are currently under utilised in Australian agriculture due to poor adaptation, however they offer significant benefits both for soil improvement and the production of high protein crops. This p ....Accelerating pulse breeding using machine learning. Advances in genomics and high throughput phenotyping are generating vast quantities of data that can be applied for crop improvement, however the lack of computational analysis tools and approaches limits the full exploitation of this data. Pulse legumes are currently under utilised in Australian agriculture due to poor adaptation, however they offer significant benefits both for soil improvement and the production of high protein crops. This project will develop machine learning (ML) tools for the analysis of pulse legume crop traits and their association with genomic variation to accelerate the breeding of high performance pulse legumes for Australian growers.Read moreRead less
Immobilized biocatalysts on selected filter media to control odour emissions from wastewater treatment and composting facilities. Odour is one of the common problems faced by wastewater and solid waste industries as a result of public complaints about poor local air quality. Although odour removal technologies exist, they encounter a number of problems. The lack of harsh chemicals required for the proposed technology means there is no wastewater stream to treat. This will have an impact on the r ....Immobilized biocatalysts on selected filter media to control odour emissions from wastewater treatment and composting facilities. Odour is one of the common problems faced by wastewater and solid waste industries as a result of public complaints about poor local air quality. Although odour removal technologies exist, they encounter a number of problems. The lack of harsh chemicals required for the proposed technology means there is no wastewater stream to treat. This will have an impact on the reduction of chemicals disposed to the environment, preventing unnecessary contamination of land and water resources. The lower space requirement of the technology will free up land, formerly required for large biofilters, for other uses including civic amenities.Read moreRead less
Characterisation of snake venom components and screening venom for bioactive compounds. Animal venoms are a rich source of bioactive compounds. This project will separate and characterise the protein-containing components of the North Queensland taipan. It will also involve constructing a cDNA library from mRNA isolated from the venom glands of the same snake and individual clones will be isolated and sequenced. Individual snake venom components, purified either from whole snake venom or synthes ....Characterisation of snake venom components and screening venom for bioactive compounds. Animal venoms are a rich source of bioactive compounds. This project will separate and characterise the protein-containing components of the North Queensland taipan. It will also involve constructing a cDNA library from mRNA isolated from the venom glands of the same snake and individual clones will be isolated and sequenced. Individual snake venom components, purified either from whole snake venom or synthesised via in vivo expression, will be tested in a variety of rapid throughput screening assays to identify specific bioactivities. This project will train a post graduate scientist in methods involved in the discovery of novel bioactive compounds.Read moreRead less
Improving the analysis of trace DNA samples in forensic science and human identification. The introduction of DNA technology into forensic science has revolutionised this profession, by generating a very high level of individual discrimination through genetic profiling. However, there are still many crime scenes from which it is proving difficult to obtain sufficient DNA sample for such powerful profiling. This project will develop modifications to current techniques and procedures, as well as ....Improving the analysis of trace DNA samples in forensic science and human identification. The introduction of DNA technology into forensic science has revolutionised this profession, by generating a very high level of individual discrimination through genetic profiling. However, there are still many crime scenes from which it is proving difficult to obtain sufficient DNA sample for such powerful profiling. This project will develop modifications to current techniques and procedures, as well as new novel approaches, to improve the targeting, collection, extraction and typing of trace amounts of biological samples. These results will significantly improve our ability to fight crime, especially high volume crime, act as a deterrent, and assist in disaster victim identification.Read moreRead less
Application of direct protein transduction of Stem Cell Factors to reprogram mouse and human somatic cells into pluripotent stem cells. This project aims to generate embryonic stem cell-like cells from human somatic cells, using direct protein transduction of defined factors, rather than through retroviral delivery. This will bring stem cell application closer to a therapeutic setting. The cells produced will be free from genetic modification and will yield products for patient-specific cell-ba ....Application of direct protein transduction of Stem Cell Factors to reprogram mouse and human somatic cells into pluripotent stem cells. This project aims to generate embryonic stem cell-like cells from human somatic cells, using direct protein transduction of defined factors, rather than through retroviral delivery. This will bring stem cell application closer to a therapeutic setting. The cells produced will be free from genetic modification and will yield products for patient-specific cell-based therapies that will be accepted by recipients without the need for immunosuppressant therapy. This development is expected to revolutionize the current approach to treating disease and injury, and is likely to result in the generation of highly marketable potent cell reprogramming therapeutics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775758
Funder
Australian Research Council
Funding Amount
$587,000.00
Summary
A Mass Spectrometry and Proteomics Facility. This facility will support a large group of nationally and internationally recognised scientists working on a range of projects in the National Interest: the role of apoptosis in normal and diseased cells, mitochondrial biogenesis and genetic diseases resulting from defects in mitochondrial function, malarial vaccine and drug development, plant biotehnology, design and synthesis of drugs, DNA-anticancer drug interactions and biomarker discovery. By su ....A Mass Spectrometry and Proteomics Facility. This facility will support a large group of nationally and internationally recognised scientists working on a range of projects in the National Interest: the role of apoptosis in normal and diseased cells, mitochondrial biogenesis and genetic diseases resulting from defects in mitochondrial function, malarial vaccine and drug development, plant biotehnology, design and synthesis of drugs, DNA-anticancer drug interactions and biomarker discovery. By supporting this wide range of well funded researh, the mass spectrometry facility will support the emerging Biotechnology sector and National Research Priorities.Read moreRead less
Expression of value added product in wheat. Wheat is an important food crop due to nutritional value of its seeds. Advances in development of reliable methods for plant genetic transformation now make it possible to apply genetic engineering to the improvement of this important crop. In this linkage application, we aim to introduce a gene for a value added nutraceutical product in elite cultivars of wheat. The successful outcome of the proposed project will lead to the development of value ad ....Expression of value added product in wheat. Wheat is an important food crop due to nutritional value of its seeds. Advances in development of reliable methods for plant genetic transformation now make it possible to apply genetic engineering to the improvement of this important crop. In this linkage application, we aim to introduce a gene for a value added nutraceutical product in elite cultivars of wheat. The successful outcome of the proposed project will lead to the development of value added wheat varieties that cannot be achieved through conventional breeding and will provide Australian industry competitive advantage in rapidly growing world wide market for new health promoting foods.Read moreRead less