Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775758
Funder
Australian Research Council
Funding Amount
$587,000.00
Summary
A Mass Spectrometry and Proteomics Facility. This facility will support a large group of nationally and internationally recognised scientists working on a range of projects in the National Interest: the role of apoptosis in normal and diseased cells, mitochondrial biogenesis and genetic diseases resulting from defects in mitochondrial function, malarial vaccine and drug development, plant biotehnology, design and synthesis of drugs, DNA-anticancer drug interactions and biomarker discovery. By su ....A Mass Spectrometry and Proteomics Facility. This facility will support a large group of nationally and internationally recognised scientists working on a range of projects in the National Interest: the role of apoptosis in normal and diseased cells, mitochondrial biogenesis and genetic diseases resulting from defects in mitochondrial function, malarial vaccine and drug development, plant biotehnology, design and synthesis of drugs, DNA-anticancer drug interactions and biomarker discovery. By supporting this wide range of well funded researh, the mass spectrometry facility will support the emerging Biotechnology sector and National Research Priorities.Read moreRead less
Novel biodiagnostic platforms for human metabolites. The innovative biosensor technologies developed in this project will be utilised at first by Australian athletes, enabling them to better monitor physiological conditions during training and thereby help maintain international competitiveness. Real-time sensing of lactate and other metabolites in athletes using advanced biomaterials coupled to frontier telemetry protocols for remote sensing will be extendable to bio-diagnostic needs in human h ....Novel biodiagnostic platforms for human metabolites. The innovative biosensor technologies developed in this project will be utilised at first by Australian athletes, enabling them to better monitor physiological conditions during training and thereby help maintain international competitiveness. Real-time sensing of lactate and other metabolites in athletes using advanced biomaterials coupled to frontier telemetry protocols for remote sensing will be extendable to bio-diagnostic needs in human health care and have significant social and economic benefits. Australia's international position in the application of interfacial science and nanomaterials for outcomes in biomedical engineering will be strengthened. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989341
Funder
Australian Research Council
Funding Amount
$690,000.00
Summary
Advanced NanoBiomaterials Imaging Facility. The convergence of nanotechnology with biotechnology offers unprecedented opportunities to prepare nanomaterials with defined structure and function on the nanometre scale. However, the small length scales involved in nanomaterials present challenges in their characterisation, and in turn, their interaction with biological systems. The Advanced NanoBiomaterials Imaging Facility will provide state-of-the-art equipment for examining the properties of nan ....Advanced NanoBiomaterials Imaging Facility. The convergence of nanotechnology with biotechnology offers unprecedented opportunities to prepare nanomaterials with defined structure and function on the nanometre scale. However, the small length scales involved in nanomaterials present challenges in their characterisation, and in turn, their interaction with biological systems. The Advanced NanoBiomaterials Imaging Facility will provide state-of-the-art equipment for examining the properties of nanomaterials and their interaction with biosystems. The equipment will facilitate the development of new materials that are expected to underpin advances in drug delivery, diagnostics and implant devices, further strengthening Australia's strong reputation in these areas.Read moreRead less
Control of Protein Attachment and its Optical Detection. Protein array technologies have applications in the rapid diagnosis of disease. Biosensors can detect traces of biohazards. Before widespread implementation of these technologies can occur however, a rapid, sensitive and convenient readout method for the control and readout of attachment of proteins to antibodies is needed. I will use electric fields, combined with array imaging at surface plasmon resonance to achieve this aim. This protei ....Control of Protein Attachment and its Optical Detection. Protein array technologies have applications in the rapid diagnosis of disease. Biosensors can detect traces of biohazards. Before widespread implementation of these technologies can occur however, a rapid, sensitive and convenient readout method for the control and readout of attachment of proteins to antibodies is needed. I will use electric fields, combined with array imaging at surface plasmon resonance to achieve this aim. This protein diagnostic array technology will enable accurate and rapid diagnosis of disease, generating savings on health costs and improving public health. Manufacture in Australia will bring further economic benefits.Read moreRead less
Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate impr ....Ultrasound in muscle vascular research, and gene therapy. This project focuses on ultrasound and microbubbles for the imaging of microvascular blood flow patterns in skeletal muscle and as a modality for drug delivery. The aim is to develop and refine technology specifically for (i) assessment of muscle microvascular flow in health and disease, and for (ii) delivery of state-of-the art gene constructs to endothelial cells that control blood flow in the muscle microvasculature. We anticipate improved technology for early diagnosis of impairment in microvascular flow relevant to muscle insulin resistance and novel therapeutics that improve muscle microvascular blood flow applicable to the treatment of diabetes.Read moreRead less
Blood flow routes in muscle. Ageing well, ageing productively. The Australian population is ageing. The proportion of the population over the age of 65 is expected to greatly increase, reaching 22% by the year 2030. The prevalence of type 2 diabetes in this older population is thought to be ~20%, compared to ~6% in younger populations. An initial cause of type 2 diabetes may be microvascular dysfunction brought on by physical inactivity. Therefore this project addresses the concepts of microvasc ....Blood flow routes in muscle. Ageing well, ageing productively. The Australian population is ageing. The proportion of the population over the age of 65 is expected to greatly increase, reaching 22% by the year 2030. The prevalence of type 2 diabetes in this older population is thought to be ~20%, compared to ~6% in younger populations. An initial cause of type 2 diabetes may be microvascular dysfunction brought on by physical inactivity. Therefore this project addresses the concepts of microvascular function and microvascular fitness by using the latest technology to map blood flow routes in muscle under a number of relevant situations. Read moreRead less
Microdialysis for monitoring changes in microvascular flow patterns in muscle. Microdialysis is a technique for sampling interstitial fluid. Factors altering vascular delivery and removal of nutrients and hormones can affect muscle metabolism by altering exchange with the interstitium. This project focuses on microdialysis for assessing the impact of microvascular blood flow patterns on skeletal muscle metabolism and contractility. The aim is to develop and refine the technology, including equat ....Microdialysis for monitoring changes in microvascular flow patterns in muscle. Microdialysis is a technique for sampling interstitial fluid. Factors altering vascular delivery and removal of nutrients and hormones can affect muscle metabolism by altering exchange with the interstitium. This project focuses on microdialysis for assessing the impact of microvascular blood flow patterns on skeletal muscle metabolism and contractility. The aim is to develop and refine the technology, including equations, specifically for monitoring the nutritive fraction of blood flow in muscle by agents and factors relating to health and disease. This technique could be used for screening drugs in the treatment of diseases such as type 2 diabetes and related conditions.Read moreRead less
Engineering of anti-platelet antibodies for the diagnosis and therapy of infants with bleeding disorders. Foeto-maternal alloimmune thrombocytopenia (FMAIT) is a serious clinical condition where infants suffer potentially fatal bleeding disorders from 14 weeks gestation to 1-2 weeks post delivery. The cause of the disease is through maternal antibodies destroying foetal platelets. Our aim is to produce human antibodies, which will be used as diagnostic agents to screen for the condition in preg ....Engineering of anti-platelet antibodies for the diagnosis and therapy of infants with bleeding disorders. Foeto-maternal alloimmune thrombocytopenia (FMAIT) is a serious clinical condition where infants suffer potentially fatal bleeding disorders from 14 weeks gestation to 1-2 weeks post delivery. The cause of the disease is through maternal antibodies destroying foetal platelets. Our aim is to produce human antibodies, which will be used as diagnostic agents to screen for the condition in pregnant women, and to further develop such antibodies for therapy. Identification of mothers at risk of FMAIT and the development of a specific therapy are vital to the management and prevention of this serious condition.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452281
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessmen ....Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessment of adaptation to physical training and (iii) the development of therapeutic agents used to treat diabetes. We anticipate improved technology that is fully characterized and novel therapeutics that improve microvascular blood flow.Read moreRead less
Innovation Management Strategies and Practices to Accelerate the Commercialisation Process in the Biotechnology Industry. The innovation cycle is a complex and misunderstood area of management, particularly in the Biotechnology Industry where the innovation cycle can take up to 15 years. The management literature provides anecdotal information, however, lacks theoretical models which provide guidance to Managers on how to shorten the innovation process. Therefore, the aim of this PhD research, ....Innovation Management Strategies and Practices to Accelerate the Commercialisation Process in the Biotechnology Industry. The innovation cycle is a complex and misunderstood area of management, particularly in the Biotechnology Industry where the innovation cycle can take up to 15 years. The management literature provides anecdotal information, however, lacks theoretical models which provide guidance to Managers on how to shorten the innovation process. Therefore, the aim of this PhD research, which is "a world first", is to develop and test an innovation cycle model through quantitative and qualitative research. Expected outcomes include developing a valid and reliable model for measuring and predicting relationships between innovation practice and innovation performance and developing case studies for teaching purposes.Read moreRead less