Optimal Design Of Antimalarial Population Pharmacokinetic Studies
Funder
National Health and Medical Research Council
Funding Amount
$110,300.00
Summary
Each year there are more than 500 million episodes of malaria and over a million deaths. One of the main causes of this burden is inadequate treatment of young children and pregnant women. This project will improve research methods for determining effective treatment for all malaria patients, which in turn, will improve cure rates and slow the emergence and spread of drug resistance.
Disentangling The Interrelationship Between Multimordibity, Multimedicine Use, And Cardiovascular Health
Funder
National Health and Medical Research Council
Funding Amount
$480,978.00
Summary
Australians are living longer, but are also living with more health conditions and taking more medicines to treat those conditions. For people with cardiovascular disease (CVD), this is a problem as hundreds of non-cardiac medicines known to increase the risk of cardiovascular events, such as myocardial infarction, stroke, or heart failure. We will take a holistic, patient-centred approach determine the true burden of CVD related to use of medicines to treat comorbid conditions in Australia.
My research activities can be broadly classified into three strands: epidemiology of fracture, genetics of osteoporosis, and application of Bayesian approach in medical research. The major epidemiological work has included the development of models for in
Enhancing Aspects Of Time-to-event Analysis Methodology In Randomised Trials
Funder
National Health and Medical Research Council
Funding Amount
$548,446.00
Summary
Time-to-event analysis is a statistical method for examining the occurrence of disease-related events in individuals followed for varying periods of time. The method is widely used in health research. The technicalities of the methods are subtle and by paying careful attention to these this grant will provide extended methods, new software, and apply methods more effectively to gain new insights to disease progress, and to enhance the efficiency of health research.
Platform For Young Public Health Researchers To Upgrade Their Scientific Training Experience And Independent Status
Funder
National Health and Medical Research Council
Funding Amount
$1,842,500.00
Summary
This proposal builds on the applicants’ experience with existing large prospective studies and on studies of families of patients with bowel, breast or prostate cancer. The research environment will expose early career researchers to a number of multi-disciplinary approaches relating primarily to prevention of cancer, including studies of the role of diet and genetic factors in the development of cancer, as well as intervention trials to promote healthy eating and cessation of smoking. The grant ....This proposal builds on the applicants’ experience with existing large prospective studies and on studies of families of patients with bowel, breast or prostate cancer. The research environment will expose early career researchers to a number of multi-disciplinary approaches relating primarily to prevention of cancer, including studies of the role of diet and genetic factors in the development of cancer, as well as intervention trials to promote healthy eating and cessation of smoking. The grant will build Australian capacity in research at the forefront of dietary, molecular and genetic epidemiology, including the development of statistical methods for the analysis of family data, and interventions to change behaviour. The grant will also allow clustering of the largest group of genetic epidemiologist-statisticians in Australia, provide a basis for data linkage with State and Commonwealth health services data bases and allow greater development of existing links with international researchers in these areas.Read moreRead less
Systems Biology Of Asthma Development In Early Childhood
Funder
National Health and Medical Research Council
Funding Amount
$763,800.00
Summary
Recent studies have established that both human genetic susceptibility and viral infections during early childhood are important drivers of asthma development. It has also been noted that asthmatics’ airways are colonized with different bacteria to non-asthmatics. In this project we will examine how genetic susceptibility and interactions between bacteria and viruses in children's airways promote the development of allergy and asthma.
Harnessing Systems Biology To Tackle Neglected Tropical Diseases
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Neglected tropical diseases (NTD) have a devastating, long-term impact on billions of humans globally. No vaccines are available, and mass treatment strategies are leading to drug resistance. Thus, there is a major need to develop radically new and advanced interventions. By creating substantially enhanced and automated bioinformatics tools, I will unlock the fundamental molecular biology of key NTDs to underpin the design of new drugs, vaccines and diagnostics as translational outcomes.
Radiotherapy Treatment For Prostate Cancer - A Change In Practice Based On Direct Evidence For Targeting And Toxicity Effects Using Real Outcomes Data
Funder
National Health and Medical Research Council
Funding Amount
$555,129.00
Summary
Radiotherapy for prostate cancer treatment will be more effective when we have better knowledge of what patient anatomy needs to be targeted, and what needs to be avoided. This project will combine data collected during a large Australasian prostate cancer radiotherapy trial, ‘RADAR’, with data collected using new patient imaging methods to determine how patient anatomy impacts on the effectiveness of their treatment and the side-effects they experience.
An Integrated Genomic And Epigenomic Approach To Dissect The Aetiology Of Motor Neuron Disease
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Motor neuron disease (MND) is a neurological disease that destroys motor neurons, which control muscle activity, such as walking. It affects people >40 years old and most patients die within 3 years. There is no specific test for its diagnosis and there are no cures. I aim to build an independent research group to discover novel genes and epigenetic marks, and to dissect their biological function in MND. This knowledge is crucial for finding effective diagnosis, treatment and cure for MND.