Could porous pavements be a part of the urban water solution? With water demand in Australia approaching, and sometimes exceeding, limits of sustainability, there is a pressing need to find alternative water sources. At the same time, urban stormwater pollution remains a major environmental threat. These problems are particularly difficult in urban areas, due to space constraints. This project will test and refine porous pavement technology, which could help solve the 'urban water problem'. R ....Could porous pavements be a part of the urban water solution? With water demand in Australia approaching, and sometimes exceeding, limits of sustainability, there is a pressing need to find alternative water sources. At the same time, urban stormwater pollution remains a major environmental threat. These problems are particularly difficult in urban areas, due to space constraints. This project will test and refine porous pavement technology, which could help solve the 'urban water problem'. Replacing impervious areas with porous pavements will allow urban stormwater to be treated and harvested for re-use. Waterways will be protected from pollution, and the vast quantity of urban stormwater generated (similar to the total reticulated water supplied in Australia) can be harvested to sustain cities.Read moreRead less
In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function ....In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function relationships of thermohalophilic proteins. It is expected that such an understanding together with comparative bioinformatics will assist researchers to develop "designer proteins" with improved functions for different uses in biotechnology. It is also expected that this technology will be amenable for use with other thermohalophilic microbes.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
Elucidation of genetic and physiological factors controlling biosynthesis of sesquiterpenoids in sandalwood, Santalum spp. Plantation sandalwood removes pressure from natural populations and is a profitable long term investment. Australia is in a highly competitive position with regards to market supply but this cannot be taken for granted. This research seeks to understand the complex biology of sandalwood using the latest genomic and molecular technologies. This knowledge will be applied thro ....Elucidation of genetic and physiological factors controlling biosynthesis of sesquiterpenoids in sandalwood, Santalum spp. Plantation sandalwood removes pressure from natural populations and is a profitable long term investment. Australia is in a highly competitive position with regards to market supply but this cannot be taken for granted. This research seeks to understand the complex biology of sandalwood using the latest genomic and molecular technologies. This knowledge will be applied through directed, marker-assisted tree selection and improved plantation management. Ultimately we are developing a highly advanced production system with which Australia can lead Sandalwood production. Sandalwood plantations use a variety of native perennial hosts, increase biodiversity, help manage underground water resources and address carbon sequestration demands.Read moreRead less
Preparations, Properties, and Applications of New Hydrogels. This project aims to develop a new polymeric matrix system for improved biological separations such as fibrinogen, DNA and RNA. These new hydrogels and membranes will not only be capable of separating biomacromolecules, not possible within the existing systems, but will also develop a new size exclusion type separation system for electrophoresis. The success of the project will have a significant impact in the biotechnology industry. P ....Preparations, Properties, and Applications of New Hydrogels. This project aims to develop a new polymeric matrix system for improved biological separations such as fibrinogen, DNA and RNA. These new hydrogels and membranes will not only be capable of separating biomacromolecules, not possible within the existing systems, but will also develop a new size exclusion type separation system for electrophoresis. The success of the project will have a significant impact in the biotechnology industry. Particularly, it will provide efficient methodologies to fractionate a number of important blood products and strengthen Australian's leading role in this field.Read moreRead less
Advanced Siloxane Waveguide Devices for Telecommunications. This project will develop new methods for fabricating compact, high performance photonic integrated circuits (PICs) for use in future telecommunications networks in films of proprietary Inorganic Polymer Glasses (IPGs) commercialised by RPO Pty Ltd. New fabrication methods are required to overcome limitations of the current approach to patterning IPGs used by RPO Pty Ltd. Research will concentrate on hard contact lithography in conjunct ....Advanced Siloxane Waveguide Devices for Telecommunications. This project will develop new methods for fabricating compact, high performance photonic integrated circuits (PICs) for use in future telecommunications networks in films of proprietary Inorganic Polymer Glasses (IPGs) commercialised by RPO Pty Ltd. New fabrication methods are required to overcome limitations of the current approach to patterning IPGs used by RPO Pty Ltd. Research will concentrate on hard contact lithography in conjunction with dry (plasma) etching as well as ion beam milling; laser machining or UV writing for grating production. IPGs present special challenges for these technologies. The project outcomes will include new approaches to processing and the demonstration of the fabrication of innovative PICs in IPGs.Read moreRead less
New Techniques for Structural Biology and Directed Molecular Evolution. This PhD program will equip an Australian graduate with advanced training in techniques in molecular genetics and protein chemistry that are currently in high demand by the biotechnology industry, and also provide him/her with direct experience of an industrial R&D laboratory environment. Moreover, it will establish a basis for further collaboration between a leading University-based research laboratory and an established R& ....New Techniques for Structural Biology and Directed Molecular Evolution. This PhD program will equip an Australian graduate with advanced training in techniques in molecular genetics and protein chemistry that are currently in high demand by the biotechnology industry, and also provide him/her with direct experience of an industrial R&D laboratory environment. Moreover, it will establish a basis for further collaboration between a leading University-based research laboratory and an established R&D company that will lead to development of new techniques for use in biotechnology in Australia and overseas.Read moreRead less