An X-ray Crystallographic Investigation Into The Adaptive Immune Response To Epstein Barr Virus
Funder
National Health and Medical Research Council
Funding Amount
$521,961.00
Summary
This proposal is focussed on understanding the precise shape of proteins that control the immune response to Epstein Barr Virus. EBV is an ubiquitous human pathogen that has been linked to a number of cancers. This research proposal will further our understanding of the immune response to EBV, which will lay the foundations for developing therapeutics against this disease.
Foetal Determinants Of Sleep Disordered Breathing In Infants
Funder
National Health and Medical Research Council
Funding Amount
$174,691.00
Summary
Obstructive sleep apnea (OSA) has been identified and recorded in infants, however the factors that lead to the development of OSA and its prevalence in infants is unknown. We have recorded OSA in some infants and we demonstrated that the severity of apnea was at its peak at approximately 2 months of age and then resolved by 1 year. We hypothesised that these infants possibly had a maturational delay of breathing control during sleep. This project is designed to examine the development and preva ....Obstructive sleep apnea (OSA) has been identified and recorded in infants, however the factors that lead to the development of OSA and its prevalence in infants is unknown. We have recorded OSA in some infants and we demonstrated that the severity of apnea was at its peak at approximately 2 months of age and then resolved by 1 year. We hypothesised that these infants possibly had a maturational delay of breathing control during sleep. This project is designed to examine the development and prevalence of sleep and breathing disorders in infants. The prenatal factors that possibly influence development of sleep and breathing disorders in infants, in particular, the effects of maternal smoking will be determined. Pregnant women will be recruited for the study during their third trimester. The foetal movements, foetal breathing movements, heart rate and sleep state will be monitored continuously overnight in the patients home between 32 and 36 weeks gestation using a newly developed foetal movement monitor. The infants will be subsequently studied using overnight polysomnography at 2 months of age to assess their breathing, sleep patterns, arousal behaviour, and the presence and severity of central and obstructive apnea. A group from these infants will be selected and studied longitudinally to examine the development of sleep and breathing disorders more closely. These infants will undergo overnight sleep studies during the first week of life, then at 2 and 6 months of age. A detailed medical history will also be collected regarding the pregnancy, the perinatal history of the infant, exposure to cigarette smoke during pregnancy and postnatally, and the medical history of other family members. We will examine the quality and quantity of foetal movements and its association with the development of OSA. The occurrence of sleep and breathing disorders in the infants will be correlated with the foetal behaviour and, the prenatal and postnatal factors.Read moreRead less
Authenticity: Globalisation and Indigenous Culture. Who speaks for the Fourth World? Why is there an obsession with 'authenticity' whenever Indigenous people are being discussed? This study explores those questions by examining a combination of sources, ranging from international museum collections to the advertising campaigns of multinational companies; from literature to the cultural festivals of the Olympic Games. The research is original, comparative, empirical. It explores the intersectio ....Authenticity: Globalisation and Indigenous Culture. Who speaks for the Fourth World? Why is there an obsession with 'authenticity' whenever Indigenous people are being discussed? This study explores those questions by examining a combination of sources, ranging from international museum collections to the advertising campaigns of multinational companies; from literature to the cultural festivals of the Olympic Games. The research is original, comparative, empirical. It explores the intersections between postcolonial and cultural studies to speak -- not for Indigenous peoples -- but to the non-Indigenous representation of First Nations. Why? Because this provides key insights into the future of race relations in western democracies.Read moreRead less
Supporting the sustainability of Australia's local news ecosystem. This project aims to understand how Australia’s main public broadcaster, the ABC, can best support public interest journalism in rural and regional communities, with a specific focus on fragile and underserved areas of the nation’s local news ecosystem. The project will develop new knowledge around media power and how news providers can work together to secure the sustainability of local news. Expected outcomes include a framewor ....Supporting the sustainability of Australia's local news ecosystem. This project aims to understand how Australia’s main public broadcaster, the ABC, can best support public interest journalism in rural and regional communities, with a specific focus on fragile and underserved areas of the nation’s local news ecosystem. The project will develop new knowledge around media power and how news providers can work together to secure the sustainability of local news. Expected outcomes include a framework to identify and define areas of news need, an assessment of existing interventions and road-tested approaches to improve information quality. The project should provide benefits by supporting forms of local journalism that ultimately enhances the demographic health and social fabric of small towns and cities.
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Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Aus ....Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Australia, and consolidate their roles as leading outlets for Indigenous content and coverage. These outcomes are also expected to improve public understanding of issues affecting Indigenous Australians and contribute to more informed and inclusive policy discussions.Read moreRead less
Toddlers and tablets: exploring the risks and benefits 0-5s face online. Children aged between zero and five are experiencing an extraordinary shift in media consumption. They intuitively swipe screens and press buttons on tablet computers and smartphones, using apps and accessing the internet. With an estimated five-fold increase in their tablet usage (2012 to 2013), there is an urgent need for research and policy development to maximise benefit and minimise risk. This project is intended to in ....Toddlers and tablets: exploring the risks and benefits 0-5s face online. Children aged between zero and five are experiencing an extraordinary shift in media consumption. They intuitively swipe screens and press buttons on tablet computers and smartphones, using apps and accessing the internet. With an estimated five-fold increase in their tablet usage (2012 to 2013), there is an urgent need for research and policy development to maximise benefit and minimise risk. This project is intended to investigate family practices and attitudes around very young children's internet use in Australia and the United Kingdom, and is expected to contribute to public debate and evidence-based policy in Australia, the United Kingdom and Ireland. It aims to develop recommendations for policy makers and offers guidelines for parents of three age groups: zero to one, two to three and four to five.Read moreRead less
Wild Man from Borneo: species, race, representation. This project addresses the representation of species boundaries in Western accounts of the orangutan in the 19th and 20th centuries. Darwinian theory raised the possibility that animals could ?evolve?. Orangutans seemed ?closest? to humans and therefore raised key questions about the border between humans and animals. These questions were addressed in a vast range of scientific, popular, imaginative and juvenile literature. Even when ecolo ....Wild Man from Borneo: species, race, representation. This project addresses the representation of species boundaries in Western accounts of the orangutan in the 19th and 20th centuries. Darwinian theory raised the possibility that animals could ?evolve?. Orangutans seemed ?closest? to humans and therefore raised key questions about the border between humans and animals. These questions were addressed in a vast range of scientific, popular, imaginative and juvenile literature. Even when ecological models of the environment shifted attention from evolutionary potential to ecological role, orangutans retained a special status as ?sentinel? species. This project will produce a monograph examining the construction, maintenance and erosion of ideas of species boundaries.Read moreRead less
The importance of the fictional character in literary theory and cultural practice. This project is a theoretical research project which aims to make significant and innovative contributions to research excellence in literature and the history of ideas. This research focuses on the fictional character, one of the central categories of literary theory. The benefits flowing from it will primarily be an enhanced understanding of the workings and the history of a category that informs every domain o ....The importance of the fictional character in literary theory and cultural practice. This project is a theoretical research project which aims to make significant and innovative contributions to research excellence in literature and the history of ideas. This research focuses on the fictional character, one of the central categories of literary theory. The benefits flowing from it will primarily be an enhanced understanding of the workings and the history of a category that informs every domain of cultural practice.Read moreRead less
A longitudinal enquiry into Chinese women graduates' post-study experience. This longitudinal study of female Chinese graduates of Australian universities will be the first to track how international education changes these women’s lives long-term. Through in-depth interviews with graduates in China and Australia, it aims to reveal the lasting benefits of an Australian education for our international graduates, providing significant insights for the recovery of Australian international education ....A longitudinal enquiry into Chinese women graduates' post-study experience. This longitudinal study of female Chinese graduates of Australian universities will be the first to track how international education changes these women’s lives long-term. Through in-depth interviews with graduates in China and Australia, it aims to reveal the lasting benefits of an Australian education for our international graduates, providing significant insights for the recovery of Australian international education in a post-COVID world. Further, the project expects to contribute to scholarly, public and government understandings of new Chinese migrants in Australia, provide new knowledge about cultural change in the middle classes of Asia’s largest and most powerful nation, and enhance Australia’s engagement with its region.Read moreRead less
Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.