Discovery and development of novel insulin sensitising compounds for the treatment of Type 2 diabetes. Diabetes is one of the major health problems facing Australia today, and current treatments are proving inadequate to combat this disease. We previously discovered a new drug with potential for development for the treatment of diabetes. In this project, we will identify how this drug works to combat diabetes in cell and animal models, and use novel chemistry approaches to modify the drug to imp ....Discovery and development of novel insulin sensitising compounds for the treatment of Type 2 diabetes. Diabetes is one of the major health problems facing Australia today, and current treatments are proving inadequate to combat this disease. We previously discovered a new drug with potential for development for the treatment of diabetes. In this project, we will identify how this drug works to combat diabetes in cell and animal models, and use novel chemistry approaches to modify the drug to improve its properties and reduce potential side-effects. The outcomes of this project will be understanding of a new biological process that contributes to the development of diabetes, and the discovery and characterisation of new chemical compounds that could be developed as drugs to treat diabetes.Read moreRead less
New approaches to inhibition of activity of HIV integrase. This project aims to assist in the development of novel anti-HIV drugs that will benefit the 17000 Australians and more than 33 million people worldwide who are currently suffering with this terrible disease. The project will utilise state-of-the-art approaches in structure-based drug design to identify and synthesise compounds as leads for the development of anti-HIV drugs. Furthermore, the project will provide invaluable training for t ....New approaches to inhibition of activity of HIV integrase. This project aims to assist in the development of novel anti-HIV drugs that will benefit the 17000 Australians and more than 33 million people worldwide who are currently suffering with this terrible disease. The project will utilise state-of-the-art approaches in structure-based drug design to identify and synthesise compounds as leads for the development of anti-HIV drugs. Furthermore, the project will provide invaluable training for the researchers involved and enhance the relationship between the academic and commercial collaborators.Read moreRead less
Engineering new tools to aid structure determination of membrane proteins. This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project ....Engineering new tools to aid structure determination of membrane proteins. This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project outcomes are intended to lead to significant advances in membrane protein structure determination and will have a substantial impact on future research in the pharmaceutical industry.Read moreRead less
Structure-based design of inhibitors of HIV-1 integrase. This project will produce compounds that block human immunodeficiency virus (HIV) replication. These compounds will benefit the 17000 Australians and more than 34 million people worldwide who are currently suffering with this terrible disease.
Play about Place: Expanding the impact of Creative Placemaking after COVID. This project aims to establish a new approach to placemaking through the development of urban play projects. The project expects to generate affordable and engaging experiences that activate existing public spaces, a typology and methodology for analysing the impacts of urban play, and a comparative study of urban play in Melbourne and Christchurch. Expected outcomes include creative placemaking strategies and projects, ....Play about Place: Expanding the impact of Creative Placemaking after COVID. This project aims to establish a new approach to placemaking through the development of urban play projects. The project expects to generate affordable and engaging experiences that activate existing public spaces, a typology and methodology for analysing the impacts of urban play, and a comparative study of urban play in Melbourne and Christchurch. Expected outcomes include creative placemaking strategies and projects, a connected impact study, and an industry resource for local government outlining our approach. This should provide significant benefits, including First Peoples storytelling experiences, city activation post-pandemic, community engagement, the potential to create jobs and provide economic and social benefit for Australia.Read moreRead less
Codesigning processes to improve technology service provision for aged care. This research investigates the learning and implementation of novel technologies applying a participatory approach with aged care residents. In partnership with Martin Luther Homes (a not-for-profit aged care provider) and The Brainary (an educational technology provider), we will co-design recommendations and innovative services that are necessary to enable strategic planning and technology uptake of residents. We cre ....Codesigning processes to improve technology service provision for aged care. This research investigates the learning and implementation of novel technologies applying a participatory approach with aged care residents. In partnership with Martin Luther Homes (a not-for-profit aged care provider) and The Brainary (an educational technology provider), we will co-design recommendations and innovative services that are necessary to enable strategic planning and technology uptake of residents. We create value through the shared goal orientation bringing use of technology in aged care and business together as a service. Co-creating processes exploring technologies with older adults will translate into residents receiving the support they need. We can expect to achieve better quality of care and equity in technology use. Read moreRead less
The design and construction of quality, sustainable and affordable pre-made housing in Australia - optimisation and integration. Historically, industrialised construction has resulted in an industrialisation of the parts, rather than an industrialisation of the ensemble. In contrast, this project will integrate architecture and engineering, as well as construction and development to optimise the ensemble, and deliver architectural quality in industrially produced affordable housing.
The sound of space: architecture for improved auditory performance in the age of digital manufacturing. This project will combine complex custom architectural surface design with acoustic modelling and simulation to look for novel solutions to the challenges of noisy interiors. It will apply digital modelling in new ways including the construction of high fidelity full scale prototypes for testing in an open office environment and a church.
Novel chemoenzymatic synthesis and bioconjugation of peptides and proteins. This project aims to solve the critical difficulty of producing the complex peptide insulin and related insulin-like peptides (INSLs) and their analogues. The project will use unique, recyclable enzymes which ligate smaller peptide segments with extraordinary site and substrate selectivity. The expected outcome of the project is novel, cheaper and scalable, enzyme-mediated engineering of this critical class of peptides a ....Novel chemoenzymatic synthesis and bioconjugation of peptides and proteins. This project aims to solve the critical difficulty of producing the complex peptide insulin and related insulin-like peptides (INSLs) and their analogues. The project will use unique, recyclable enzymes which ligate smaller peptide segments with extraordinary site and substrate selectivity. The expected outcome of the project is novel, cheaper and scalable, enzyme-mediated engineering of this critical class of peptides as biological probes and potential therapeutic agents.Read moreRead less
Design guidelines for safety-critical controllers in high-risk environments. This project aims to generate novel product design guidelines for developing safer controllers for use by potentially stressed individuals in high-risk situations. It will do this by generating specific insights and verifying generalisable solutions from the context of total artificial heart recipients –who must engage with critical controllers constantly. This project expects to generate new knowledge in design by esta ....Design guidelines for safety-critical controllers in high-risk environments. This project aims to generate novel product design guidelines for developing safer controllers for use by potentially stressed individuals in high-risk situations. It will do this by generating specific insights and verifying generalisable solutions from the context of total artificial heart recipients –who must engage with critical controllers constantly. This project expects to generate new knowledge in design by establishing a new research topic around an under-examined user cohort. Expected outcomes of this project include interaction design theory developments and improved controller design techniques. This should provide significant benefits and competitive advantages by lowering stress and improving safety across a range of contexts.Read moreRead less