Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovativ ....Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovative and broadly-applicable neuroscience methods and an understanding of receptors involved in plant growth and defense. Benefits of this project include an enhanced capacity to generate knowledge, multidisciplinary training opportunities and patentable synthetic biology technologies.Read moreRead less
Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to b ....Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to be considered for each design decision. This will greatly reduce rework and poor design decisions based on missed information. It will also ensure that participants are aware of all related information for their particular design tasks.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346895
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance ex ....A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance existing excellence in a range of areas. Finally, the laboratory will provide opportunities to: collaborate and consult with industry; train postgraduate students in instrumentation used at the cutting edge of chemical and biochemical sciences.Read moreRead less
Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive t ....Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive the best performing metaconcrete and verify its static and dynamic load resistant capacities. The expected outcomes of the project will lead to innovative extreme-loading resistant designs and provide significant benefit to the Australian construction industry, general public and economy.Read moreRead less
Determining the social value of extreme, mixed-use urban developments. Using an Adelaide case study, UCity, this project will investigate the social benefit of building mixed-use vertical communities in the Australian urban context. Using an innovative Social Value Framework, the project will establish and demonstrate the multi-dimensional impacts of such developments in practice. The project utilises citizen science for real time auditing of the built environment by residents and users; smart t ....Determining the social value of extreme, mixed-use urban developments. Using an Adelaide case study, UCity, this project will investigate the social benefit of building mixed-use vertical communities in the Australian urban context. Using an innovative Social Value Framework, the project will establish and demonstrate the multi-dimensional impacts of such developments in practice. The project utilises citizen science for real time auditing of the built environment by residents and users; smart technologies for environmental and behavioural monitoring; and data analytics and design automation for spatial analysis of building use. The results will inform new models of sustainable high-rise, mixed-use buildings; providing evidence for a Social Value Framework to become a core consideration in Australian industry.Read moreRead less
Special Research Initiatives - Grant ID: SR200200989
Funder
Australian Research Council
Funding Amount
$280,343.00
Summary
The Australian Mosque Today: Architectural Collaborations. This project aims to investigate collaborations between architects and Muslim communities in Australia. The project will analyze ten mosques, from design consultation through to construction, completed since 2000. This focus on the professional design process will provide innovative insights into creative collaboration and cross-cultural engagement. Expected outcomes of this project include a significant, richly nuanced counter-narrative ....The Australian Mosque Today: Architectural Collaborations. This project aims to investigate collaborations between architects and Muslim communities in Australia. The project will analyze ten mosques, from design consultation through to construction, completed since 2000. This focus on the professional design process will provide innovative insights into creative collaboration and cross-cultural engagement. Expected outcomes of this project include a significant, richly nuanced counter-narrative to pervasive, isolationist representations of Australian Muslim communities. The findings will be presented in scholarly publications and a major public exhibition to promote new knowledge about the place of Islam in Australia and to build faith (literally and metaphorically) in multicultural Australia.
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Biologically active peptides from Australian and Russian Amphibians. Bowie's group has identified many host-defence peptides from Australian anurans, including antimicrobial and anticancer active peptides, and neuropeptides that inhibit the formation of the ubiquitous chemical messenger nitric oxide. Lebedev's group from Moscow have initiated a collaboration with us to investigate active peptides from unstudied Russian frogs and newts. Preliminary investigations show these are very different f ....Biologically active peptides from Australian and Russian Amphibians. Bowie's group has identified many host-defence peptides from Australian anurans, including antimicrobial and anticancer active peptides, and neuropeptides that inhibit the formation of the ubiquitous chemical messenger nitric oxide. Lebedev's group from Moscow have initiated a collaboration with us to investigate active peptides from unstudied Russian frogs and newts. Preliminary investigations show these are very different from those isolated from Australian anurans and some already show potential for development as pharmaceuticals.Read moreRead less
Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining lif ....Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining life of the building. The only related research involves reinforced concrete which suggests that a reduction of at least 33 per cent could be expected. Hence, this project will quantify the long-term strength of FRP reinforced brickwork to enable engineers to safely apply this new cost-effective retrofit technique.Read moreRead less
Improved seismic resilience against life-safety hazard of masonry buildings. This project aims to develop a cost-effective technique to mitigate the safety risk posed by the many unreinforced brick masonry parapets and walls which are vulnerable to seismic shock. Every Australian city has many streets lined with older unreinforced brick masonry buildings (now cafes, pubs, boutique shops) which feature parapets. The project will provide benefits to society by reducing the potential for parapet co ....Improved seismic resilience against life-safety hazard of masonry buildings. This project aims to develop a cost-effective technique to mitigate the safety risk posed by the many unreinforced brick masonry parapets and walls which are vulnerable to seismic shock. Every Australian city has many streets lined with older unreinforced brick masonry buildings (now cafes, pubs, boutique shops) which feature parapets. The project will provide benefits to society by reducing the potential for parapet collapse and therefore reduce the total number of fatalities in an earthquake. Building owners and engineers will be benefit from the design guidance provided by this project, which will lead to a suite of fully-tested and low-cost retrofit techniques.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less