Understanding the molecular basis of heparanase activity. This project aims to advance our understanding of the structure and impact on biological processes of heparanase (HSPE), an enzyme of critical importance. HSPE’s ability to interact with heparan sulfate (HS), a key component of the extracellular matrix and basement membranes, makes HPSE a pivotal enzyme in many important physiological and disease-related processes ranging from angiogenesis, tumour metastasis, inflammation, hair follicle ....Understanding the molecular basis of heparanase activity. This project aims to advance our understanding of the structure and impact on biological processes of heparanase (HSPE), an enzyme of critical importance. HSPE’s ability to interact with heparan sulfate (HS), a key component of the extracellular matrix and basement membranes, makes HPSE a pivotal enzyme in many important physiological and disease-related processes ranging from angiogenesis, tumour metastasis, inflammation, hair follicle development to wrinkle formation. The knowledge gained through this project is expected to provide new insight into the interaction between HSPE and HS/HSPG to reveal new pathways to the development of inhibitors to treat diseases such as cancer and diabetes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100142
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An integrated liquid chromatography mass spectrometry nuclear magnetic resonance (LC-MS-NMR) facility for applications in proteomics and organic chemistry. This application completes the requested liquid chromatography mass spectrometry nuclear magnetic resonance (LCMS-NMR) facility and will allow the training of over 150 researchers, significantly enhancing their research productivity and translation of outcomes in areas of national importance. New breakthroughs in drug development, smart mate ....An integrated liquid chromatography mass spectrometry nuclear magnetic resonance (LC-MS-NMR) facility for applications in proteomics and organic chemistry. This application completes the requested liquid chromatography mass spectrometry nuclear magnetic resonance (LCMS-NMR) facility and will allow the training of over 150 researchers, significantly enhancing their research productivity and translation of outcomes in areas of national importance. New breakthroughs in drug development, smart materials, organic electronic materials and biomedical research require routine access to cutting edge technology. The LCMS-NMR augments the capabilities of our research teams at the forefront of these efforts. These include understanding the impact of the environment on plant and animal development, pest animal control, development of new biotechnology tools, new drugs and new methods for the detection of narcotics and explosives.Read moreRead less
Protein design. This project aims to design binding specificity in proteins in a rational way. Extending the existing repertoire of protein specificity using engineering principles should harness the catalytic power and high binding affinities of natural proteins. By building upon protein design algorithms, this project will develop biosensors for neurotransmitters and specialist enzymes to incorporate unnatural amino acids. It will iteratively improve the designs and algorithms by computational ....Protein design. This project aims to design binding specificity in proteins in a rational way. Extending the existing repertoire of protein specificity using engineering principles should harness the catalytic power and high binding affinities of natural proteins. By building upon protein design algorithms, this project will develop biosensors for neurotransmitters and specialist enzymes to incorporate unnatural amino acids. It will iteratively improve the designs and algorithms by computational and experimental characterisation. The outcomes should address the long-standing need in synthetic biology for a facile route to designer proteinsRead moreRead less
Discovery and characterisation of novel spider-venom peptides targeting the human sodium ion channel Nav1.7. Drugs that selectively block the human sodium ion channel Nav1.7 are likely to be powerful analgesics for treating a wide variety of pain conditions. However, it has proved difficult to obtain selective blockers of this channel. The aim of this project is to determine whether spider-venoms might provide a source of highly selective Nav1.7 blockers.
Discovery Early Career Researcher Award - Grant ID: DE190100015
Funder
Australian Research Council
Funding Amount
$405,000.00
Summary
Global positioning system for small molecules: accelerating lead discovery. This project aims to establish a tool to accelerate lead generation from very small molecules. This will shift the paradigm in the identification of small molecules that can serve as lead compounds for the development of specific probes or drugs. This project offers a new strategy to rapidly generate lead compounds from a library of compound fragments. The new approach is expected to facilitate identification and develop ....Global positioning system for small molecules: accelerating lead discovery. This project aims to establish a tool to accelerate lead generation from very small molecules. This will shift the paradigm in the identification of small molecules that can serve as lead compounds for the development of specific probes or drugs. This project offers a new strategy to rapidly generate lead compounds from a library of compound fragments. The new approach is expected to facilitate identification and development of new lead molecules, drawing on advances made in the field of fragment-based lead discovery, which is increasingly used in the pharmaceutical industries. The tools developed can also be applied for imaging of biological processes. By developing new technologies, the project should deliver intellectual property with potential for commercialisation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100174
Funder
Australian Research Council
Funding Amount
$805,000.00
Summary
Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smar ....Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smart, productive and resilient cities. These capabilities are predicated on the adoption of ISO standards, development of new ontological frameworks and an urban data dictionary to enable semantic inferencing of datasets and the development of data structures and services. This framework would then be applied to data relevant to people, land and urban infrastructure to support comparative and multi-dimensional analytics. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
Effects Of Biological And Environmental Factors And Of Fishing Practices On Recruitment And Abundance Of Scallops
Funder
Fisheries Research and Development Corporation
Funding Amount
$55,396.00
Summary
Objectives: 1. To determine information needs for developing a predictive model based on environmental and fisheries variables 2. To collate all the existing and relevant local data on scallop recruitment and abundance, associated environmental factors and fishing effort 3. Combine these data into a model describing relationships between environment, fishing effort, recruitment and abundance 4. Build a model of the fishery using the Port Phillip Bay data (which is the most ....Objectives: 1. To determine information needs for developing a predictive model based on environmental and fisheries variables 2. To collate all the existing and relevant local data on scallop recruitment and abundance, associated environmental factors and fishing effort 3. Combine these data into a model describing relationships between environment, fishing effort, recruitment and abundance 4. Build a model of the fishery using the Port Phillip Bay data (which is the most comprehensive data set). Include sensitivity analysis. Identify any additional data needs 5. Determine suitabilityof the Port Phillip Bay model for modelling the scallop fishery in south-eastern Australia 6. Recommend further course of action for data collection and fisheries management in order to refine the model Read moreRead less
Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization ....Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization tools and numerical models. The final outcome of the project will be a set of designs of the columns, which should be more efficient, safer and cheaper to operate, and have smaller physical and environmental footprints, thus helping the Australian LNG industry to stay globally competitive.Read moreRead less
NCCP: Review Of Carp Control Via Commercial Exploitation
Funder
Fisheries Research and Development Corporation
Funding Amount
$36,863.00
Summary
The National Carp Control Plan (NCCP) is presently considering strategies that will effect widespread control of a dominant invasive freshwater fish, the Carp (Cyprinus carpio). Carp have a significant negative impact on social, environmental and economic ($500 million per year) outcomes in aspects of water quality, amenity and biodiversity. Carp dominate the Murray–Darling Basin, making up 80-90 per cent of the fish biomass in places. In Australia, the use of a biological control agent, the na ....The National Carp Control Plan (NCCP) is presently considering strategies that will effect widespread control of a dominant invasive freshwater fish, the Carp (Cyprinus carpio). Carp have a significant negative impact on social, environmental and economic ($500 million per year) outcomes in aspects of water quality, amenity and biodiversity. Carp dominate the Murray–Darling Basin, making up 80-90 per cent of the fish biomass in places. In Australia, the use of a biological control agent, the naturally occurring carp herpesvirus, could significantly reduce the number of carp in our freshwater systems [1-3]. The NCCP will map out the best approach to manage the required work safely with a key step towards the potential strategic release of carp herpesvirus being community consultation.
One common theme amongst community comments about carp control is “Can we fish them all out through overfishing?” Proponents cite examples of over-exploited commercial fisheries worldwide that have collapsed. This reaction is particularly prevalent amongst the commercial fishing sector of the community [4]. Similar arguments are made against investment in many ‘technologies’ for many vertebrate pest-control strategies; particularly where the pest-animals have a value in an exploitative industry or where effective alternatives are lacking. Other fish-examples include Asian carp species in the Mississippi Basin (Visser 2017), Lionfish in the Caribbean (Downey 2017) and Aripaima or Paiche invading Bolivia (Snyder 2017). Existing studies of the feasibility of Carp control by removal are few in Australia [5, 6] particularly in peer reviewed literature [7]. There is a clear need for peer-reviewed evaluation (including a plain-speech, magazine article version) of the potential for commercial, or subsidised, fishery exploitation to effectively control carp populations in Australia. The proposed research will inform the community consultation process about the potential for deliberate overfishing to complement or to be an effective alternative to virus release.
Objectives: 1. Review literature on control of vertebrate pests through commercial exploitation (with emphasis on pest-fish) 2. Use CarpSim software to explore the limits of critical factors identified in the literature review, with respect to control of Carp in Australia through commercial exploitation 3. Summarise findings of review (1) and modelling (2) in lay persons terms, in a magazine article, to answer questions such as "Can we just fish them all out with commercial fishing?" 4. Prepare and submit a research article based on review (1) and modelling (2) for publication in a peer-reviewed, open-access, scientific journal Read moreRead less