Engineered extrasynaptic GABAA receptors: Towards novel analgesics. Engineered extrasynaptic GABAA receptors: Towards novel analgesics. This project intends to alleviate neuropathic pain by developing drugs and good tool molecules targeting GABA-A receptors. About 20% of Australian adults suffer from neuropathic pain. Delta-containing GABA-A receptors represent attractive and novel targets for developing non-opioid analgesics. However, no drugs or good tool molecules target these receptors. This ....Engineered extrasynaptic GABAA receptors: Towards novel analgesics. Engineered extrasynaptic GABAA receptors: Towards novel analgesics. This project intends to alleviate neuropathic pain by developing drugs and good tool molecules targeting GABA-A receptors. About 20% of Australian adults suffer from neuropathic pain. Delta-containing GABA-A receptors represent attractive and novel targets for developing non-opioid analgesics. However, no drugs or good tool molecules target these receptors. This project intends to develop the needed enabling technologies, including screening assays, tool molecules and radioligands; and perform brain slice electrophysiology to confirm activity in neuronal cells. This project is expected to benefit the research community and future rational drug-discovery endeavours for drugs that modulate delta-containing receptors.Read moreRead less
Discovery and development of novel insulin sensitising compounds for the treatment of Type 2 diabetes. Diabetes is one of the major health problems facing Australia today, and current treatments are proving inadequate to combat this disease. We previously discovered a new drug with potential for development for the treatment of diabetes. In this project, we will identify how this drug works to combat diabetes in cell and animal models, and use novel chemistry approaches to modify the drug to imp ....Discovery and development of novel insulin sensitising compounds for the treatment of Type 2 diabetes. Diabetes is one of the major health problems facing Australia today, and current treatments are proving inadequate to combat this disease. We previously discovered a new drug with potential for development for the treatment of diabetes. In this project, we will identify how this drug works to combat diabetes in cell and animal models, and use novel chemistry approaches to modify the drug to improve its properties and reduce potential side-effects. The outcomes of this project will be understanding of a new biological process that contributes to the development of diabetes, and the discovery and characterisation of new chemical compounds that could be developed as drugs to treat diabetes.Read moreRead less
New approaches to inhibition of activity of HIV integrase. This project aims to assist in the development of novel anti-HIV drugs that will benefit the 17000 Australians and more than 33 million people worldwide who are currently suffering with this terrible disease. The project will utilise state-of-the-art approaches in structure-based drug design to identify and synthesise compounds as leads for the development of anti-HIV drugs. Furthermore, the project will provide invaluable training for t ....New approaches to inhibition of activity of HIV integrase. This project aims to assist in the development of novel anti-HIV drugs that will benefit the 17000 Australians and more than 33 million people worldwide who are currently suffering with this terrible disease. The project will utilise state-of-the-art approaches in structure-based drug design to identify and synthesise compounds as leads for the development of anti-HIV drugs. Furthermore, the project will provide invaluable training for the researchers involved and enhance the relationship between the academic and commercial collaborators.Read moreRead less
Understanding the molecular basis of heparanase activity. This project aims to advance our understanding of the structure and impact on biological processes of heparanase (HSPE), an enzyme of critical importance. HSPE’s ability to interact with heparan sulfate (HS), a key component of the extracellular matrix and basement membranes, makes HPSE a pivotal enzyme in many important physiological and disease-related processes ranging from angiogenesis, tumour metastasis, inflammation, hair follicle ....Understanding the molecular basis of heparanase activity. This project aims to advance our understanding of the structure and impact on biological processes of heparanase (HSPE), an enzyme of critical importance. HSPE’s ability to interact with heparan sulfate (HS), a key component of the extracellular matrix and basement membranes, makes HPSE a pivotal enzyme in many important physiological and disease-related processes ranging from angiogenesis, tumour metastasis, inflammation, hair follicle development to wrinkle formation. The knowledge gained through this project is expected to provide new insight into the interaction between HSPE and HS/HSPG to reveal new pathways to the development of inhibitors to treat diseases such as cancer and diabetes.Read moreRead less
Engineering new tools to aid structure determination of membrane proteins. This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project ....Engineering new tools to aid structure determination of membrane proteins. This project aims to address the inherent instability of G protein-coupled receptors (GPCRs), which are cell-surface proteins that are a major drug targets. The instability of GPCRs has resulted in a lack of atomic-level structural information that has hindered structure-based drug discovery efforts. This project expects to develop tools to improve GPCR stability and streamline the structure determination process. Project outcomes are intended to lead to significant advances in membrane protein structure determination and will have a substantial impact on future research in the pharmaceutical industry.Read moreRead less
Structure-based design of inhibitors of HIV-1 integrase. This project will produce compounds that block human immunodeficiency virus (HIV) replication. These compounds will benefit the 17000 Australians and more than 34 million people worldwide who are currently suffering with this terrible disease.
Are acidic mine lakes usable as regional water resources? After the de-commissioning of open-cut mines, the voids frequently fill with water. In Australia, hundreds of mine lakes will develop over the next ten years and beyond. When the base mineralogy is pyritic the water can become highly acidic with high concentrations of dissolved metals. These mine lakes frequently exist in regions where water resources are in short supply. This project will investigate possible strategies to remediate such ....Are acidic mine lakes usable as regional water resources? After the de-commissioning of open-cut mines, the voids frequently fill with water. In Australia, hundreds of mine lakes will develop over the next ten years and beyond. When the base mineralogy is pyritic the water can become highly acidic with high concentrations of dissolved metals. These mine lakes frequently exist in regions where water resources are in short supply. This project will investigate possible strategies to remediate such lakes and assess the possibility of using mining lakes as valued water resources in these regions. The primary outcome of the research will be improved management of the lakes for optimal long term water quality.Read moreRead less
Integrated Autonomous Housing for Remote Australian Communities: Analysis, Synthesis and Testing. At remote mining communities, little consideration is given to comfort or energy efficiency in housing - services have not been optimised to minimise greenhouse gas emissions, water consumption and solid waste. This project will address these environmental issues and the associated social problems by combining the resources of BHP Billiton and the University of Newcastle to develop a model for remot ....Integrated Autonomous Housing for Remote Australian Communities: Analysis, Synthesis and Testing. At remote mining communities, little consideration is given to comfort or energy efficiency in housing - services have not been optimised to minimise greenhouse gas emissions, water consumption and solid waste. This project will address these environmental issues and the associated social problems by combining the resources of BHP Billiton and the University of Newcastle to develop a model for remote housing. The project aims to design and test an integrated low impact or autonomous transportable house. The results of this research are applicable to remote defence sites, small rural townships and Aboriginal communities as well as for international export.Read moreRead less
Life Cycle Measures of Cost Effectiveness for 4 D CAD in Design and Construct Projects across Industry Sectors. The effective and efficient delivery of complex construction projects will be transformed by the increased application of virtual design and construction technologies, including 4D CAD. By combining a 3D computer model of a design with the time dimension of the construction schedule, 4D CAD enables risks and opportunities to be better managed during the design phase and hence avoid co ....Life Cycle Measures of Cost Effectiveness for 4 D CAD in Design and Construct Projects across Industry Sectors. The effective and efficient delivery of complex construction projects will be transformed by the increased application of virtual design and construction technologies, including 4D CAD. By combining a 3D computer model of a design with the time dimension of the construction schedule, 4D CAD enables risks and opportunities to be better managed during the design phase and hence avoid costly issues during construction. However this requires addition design costs which currently represent a barrier to the uptake of this transforming technology. This project will overcome this by developing a flexible framework that allows the benefits gained across the life cycle of a project through using 4D CAD to be set against the additional costs and thus make this emerging technology more attractive to industry. Significantly this research will be based on comparative cases studies across different industry sectors including civil, building, and process engineering.Read moreRead less
Play about Place: Expanding the impact of Creative Placemaking after COVID. This project aims to establish a new approach to placemaking through the development of urban play projects. The project expects to generate affordable and engaging experiences that activate existing public spaces, a typology and methodology for analysing the impacts of urban play, and a comparative study of urban play in Melbourne and Christchurch. Expected outcomes include creative placemaking strategies and projects, ....Play about Place: Expanding the impact of Creative Placemaking after COVID. This project aims to establish a new approach to placemaking through the development of urban play projects. The project expects to generate affordable and engaging experiences that activate existing public spaces, a typology and methodology for analysing the impacts of urban play, and a comparative study of urban play in Melbourne and Christchurch. Expected outcomes include creative placemaking strategies and projects, a connected impact study, and an industry resource for local government outlining our approach. This should provide significant benefits, including First Peoples storytelling experiences, city activation post-pandemic, community engagement, the potential to create jobs and provide economic and social benefit for Australia.Read moreRead less