Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovativ ....Engineered plant receptors as orthogonal neuronal switches. This project aims to develop synthetic biology methods to study brain function by utilising engineered plant receptors. This project will expand our ability to manipulate nerve cell function with high specificity and without side effects in freely behaving animals. Plant receptors will be developed into molecular tools in an iterative process that improves key properties using rational protein design. Expected outcomes include innovative and broadly-applicable neuroscience methods and an understanding of receptors involved in plant growth and defense. Benefits of this project include an enhanced capacity to generate knowledge, multidisciplinary training opportunities and patentable synthetic biology technologies.Read moreRead less
Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to b ....Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to be considered for each design decision. This will greatly reduce rework and poor design decisions based on missed information. It will also ensure that participants are aware of all related information for their particular design tasks.Read moreRead less
Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive t ....Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive the best performing metaconcrete and verify its static and dynamic load resistant capacities. The expected outcomes of the project will lead to innovative extreme-loading resistant designs and provide significant benefit to the Australian construction industry, general public and economy.Read moreRead less
Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining lif ....Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining life of the building. The only related research involves reinforced concrete which suggests that a reduction of at least 33 per cent could be expected. Hence, this project will quantify the long-term strength of FRP reinforced brickwork to enable engineers to safely apply this new cost-effective retrofit technique.Read moreRead less
Improved seismic resilience against life-safety hazard of masonry buildings. This project aims to develop a cost-effective technique to mitigate the safety risk posed by the many unreinforced brick masonry parapets and walls which are vulnerable to seismic shock. Every Australian city has many streets lined with older unreinforced brick masonry buildings (now cafes, pubs, boutique shops) which feature parapets. The project will provide benefits to society by reducing the potential for parapet co ....Improved seismic resilience against life-safety hazard of masonry buildings. This project aims to develop a cost-effective technique to mitigate the safety risk posed by the many unreinforced brick masonry parapets and walls which are vulnerable to seismic shock. Every Australian city has many streets lined with older unreinforced brick masonry buildings (now cafes, pubs, boutique shops) which feature parapets. The project will provide benefits to society by reducing the potential for parapet collapse and therefore reduce the total number of fatalities in an earthquake. Building owners and engineers will be benefit from the design guidance provided by this project, which will lead to a suite of fully-tested and low-cost retrofit techniques.Read moreRead less
Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitri ....Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitric oxide formation. Another national benefit is that personnel involved in this project are trained to the highest international standards in peptide chemistry/mass spectrometry/nuclear magnetic resonance: currently, there are not enough trained scientists in this area to meet demand.Read moreRead less
Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide ....Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide synthase. It would be of national benefit if any of these peptides have applied application, e.g. if we can use the sex pheromone of the cane toad to reduce its population, or if we can produce an anticancer active peptide of clinical applicability.Read moreRead less
Composite tubular construction subject to impact and blast loading. This project will advance the knowledge of composite tubular members and connections under impact and blast loading. It will provide confident design methodology against impact and blast loading for buildings designated as prominent targets or items of critical infrastructure, to save lives and reduce losses.
Improved analysis techniques for seismic assessment of unreinforced masonry buildings with flexible floor/roof diaphragms. A major international collaboration between researchers in Australia, New Zealand and Italy is underway to develop a method for structural engineers to determine which masonry buildings post a significant hazard to the public in the event of an earthquake such as that which struck the city of Christchurch.
Making architectural identity: the architecture of John Andrews. The important Australian architect John Andrews had a career unique for its success, first in Canada and the United States and then in Australia. Research into his design work and how it has been understood will develop new knowledge of design practices of the 1970s, how architecture is understood in terms of nationality, and how design has become globalised.