Development and characterization of a technology platform to study the mechanisms of scaffold/Bone Morphogenic Proteins (BMP) augmented large segmental bone healing. This project will increase understanding of bone engineering and in doing so will lead to superior treatments for bone defects. Such a treatment would be valuable in addressing the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. The multidisciplin ....Development and characterization of a technology platform to study the mechanisms of scaffold/Bone Morphogenic Proteins (BMP) augmented large segmental bone healing. This project will increase understanding of bone engineering and in doing so will lead to superior treatments for bone defects. Such a treatment would be valuable in addressing the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. The multidisciplinary and international team will be valuable in establishing Australia's prominence in this field and training the next generation of young scientists and engineers. The technologies developed will be of great interest to a large number of research groups and companies worldwide and will assist with fostering international collaboration and placing Australia at the forefront of this emerging field.Read moreRead less
Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100020
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
High bandwidth, high speed, terahertz optical sampling and analysis system. This project aims to promote scientific and technological research by providing access to a wide bandwidth, high speed, high resolution advanced terahertz spectrometer. Terahertz frequencies are the least-explored region of the electromagnetic spectrum and investment here is likely to yield scientific and technological reward. Expected outcomes are new commercial devices and products operating in the terahertz regime. Th ....High bandwidth, high speed, terahertz optical sampling and analysis system. This project aims to promote scientific and technological research by providing access to a wide bandwidth, high speed, high resolution advanced terahertz spectrometer. Terahertz frequencies are the least-explored region of the electromagnetic spectrum and investment here is likely to yield scientific and technological reward. Expected outcomes are new commercial devices and products operating in the terahertz regime. The project’s expected effects include new commercial terahertz products; better monitoring of explosives and toxins; research training and job creation; reduced risk in decision making, especially when monitoring water; and cultural benefits, through applying terahertz methods to artworks.Read moreRead less
ARC Centre of Excellence for Integrative Brain Function. The Centre of Excellence for Integrative Brain Function will address one of the greatest scientific challenges of the 21st century to understand how the brain works. We will investigate complex functions such as attention, prediction and decision-making, which require the coordination of information processing by many areas of the brain. This will require a highly collaborative approach involving neurobiologists, cognitive scientists, eng ....ARC Centre of Excellence for Integrative Brain Function. The Centre of Excellence for Integrative Brain Function will address one of the greatest scientific challenges of the 21st century to understand how the brain works. We will investigate complex functions such as attention, prediction and decision-making, which require the coordination of information processing by many areas of the brain. This will require a highly collaborative approach involving neurobiologists, cognitive scientists, engineers and physicists, allowing us to translate our discoveries into novel technologies for the social and economic benefit of all Australians. We will also train a new generation of multidisciplinary researchers, and contribute our expertise to a range of public education and awareness programs.Read moreRead less
Erosion of embankment dams and dam spillways. In excess of $250M is spent annually to maintain, upgrade, improve safety and monitor performance of Australian dams. Improved methods for assessing both spillway and internal erosion, the cause of 50 per cent of embankment dam failures and incidents requiring repairs, will be developed, maximising dam safety and minimising maintenance expenditure.
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560716
Funder
Australian Research Council
Funding Amount
$864,610.00
Summary
A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The o ....A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The outcome will be a strategically important Australian T-ray facility that will provide immediate and transparent nationwide access. Historically, industry is transformed every time a new part of the electromagnetic spectrum becomes accessible - T-rays are the next frontier.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100185
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
High throughput microbial microculture and single cell analysis facility. High throughput microbial microculture and single cell analysis facility:
To support the emerging research area of microbial heterogeneity and variation in response to conditions, this project aims to establish a facility centred on a 24-microbioreactor system for high throughput microbial culturing. This is designed to be connected to two complementary analysis techniques – flow cytometry and high resolution infra-red mi ....High throughput microbial microculture and single cell analysis facility. High throughput microbial microculture and single cell analysis facility:
To support the emerging research area of microbial heterogeneity and variation in response to conditions, this project aims to establish a facility centred on a 24-microbioreactor system for high throughput microbial culturing. This is designed to be connected to two complementary analysis techniques – flow cytometry and high resolution infra-red microscopy – for the non-destructive measurement of metabolic activities and mapping of constituents of whole cells. This would help us to determine the variation in response between organisms, to guide cell line development and process optimisation for a wide range of biotechnology applications. Expected outcomes may apply to Australia’s brewing, wine, food processing, aquaculture, biofuels, biomedical and biotechnology industries.Read moreRead less
Data-driven water quality treatment management decision support system. Data-driven water quality treatment management decision support system. This project aims to develop a robust decision support system to predict manganese and the character and concentration of dissolved organic matter in drinking water reservoirs, using intelligent algorithms and data collected through remote autonomous instrumentation. These predicted water quality parameters could be used as model input variables to provi ....Data-driven water quality treatment management decision support system. Data-driven water quality treatment management decision support system. This project aims to develop a robust decision support system to predict manganese and the character and concentration of dissolved organic matter in drinking water reservoirs, using intelligent algorithms and data collected through remote autonomous instrumentation. These predicted water quality parameters could be used as model input variables to provide real-time decisions for plant operators on the required treatment regime for incoming raw water, and advise them on the optimal reservoir offtake depth. This will potentially minimise treatment costs and health risks for consumers. The ultimate goal is to significantly enhance current water supply management practices.Read moreRead less